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81.
Hiram Larangeira de Almeida Jr Debora Sarzi Sartori Janaína Kopp Carolina Dahmer Velloso Valeria Magalh?es Jorge 《Anais brasileiros de dermatologia》2013,88(4):620-622
Hydroa Vaciniforme is a very rare photodermatosis that is mainly seen in childhood.
An 18 year old female student reported that since the age of 5 she has been suffering
necrotic lesions and vesicles lesions in exposed areas, leaving asymptomatic
varioliform scars, which worsened in summer. Light microscopy showed epidermal
necrosis with lymphocytic infiltration. Sunscreens were prescribed with light
improvement. 相似文献
82.
Carmine Vitale Valeria Agosti Dario Avella Gabriella Santangelo Marianna Amboni Rosaria Rucco Paolo Barone Francesco Corato Giuseppe Sorrentino 《Neurological sciences》2012,33(6):1337-1343
The aim of the present study was to evaluate the effects of a Global Postural Rehabilitation (GPR) program on motor symptoms and gait parameters of patients with Parkinson’s disease (PD) by means of three-dimensional motion analysis study. Ten subjects with clinical diagnosis of PD were enrolled (study group). Age-, sex- and disease duration-matched PD patients were recruited as a control group (no treatment). Three-dimensional motion analysis was conducted by means of a stereophotogrammetric system. After basal evaluation, the study group underwent a specific rehabilitation program consisting of individual 40?min GPR daily sessions, 3?days a week for 4 consecutive weeks. Neurological status and spatiotemporal gait parameters of the two groups were evaluated at study entry (t 0), at 4?weeks (t 1, end of rehabilitation protocol) and at 8 and 12?weeks (t 2 and t 3, follow-up evaluation). At baseline evaluation, the two groups did not differ in clinical features and gait parameters. At the end of rehabilitation protocol (t 1) and at follow-up evaluation (t 2 and t 3), a significant improvement in temporal gait parameters and UPDRS scores was observed in all treated patients as compared to baseline and controls. Our preliminary findings showed that significant improvements in mobility and gait parameters of PD patients can be obtained through GPR treatment, with a parallel improvement in clinical status. Quantitative analysis of gait pattern can be considered a useful tool to assess the efficacy of rehabilitation interventions in patients affected by PD. 相似文献
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85.
Massimiliano Cadamuro Simone Brivio Joachim Mertens Marta Vismara Anja Moncsek Chiara Milani Christian Fingas Maria Cristina Malerba Giorgia Nardo Luigi DallOlmo Eleonora Milani Valeria Mariotti Tommaso Stecca Marco Massani Carlo Spirli Romina Fiorotto Stefano Indraccolo Mario Strazzabosco Luca Fabris 《Journal of hepatology》2019,70(4):700-709
86.
Marco Cavallini Daniele Cavaniglia Francesco Felicioni Valeria Vitale Emanuela Pilozzi Vincenzo Ziparo 《Journal of hepato-biliary-pancreatic sciences》2007,14(5):526-528
A 67-year-old woman, who had symptoms of epigastric pain and abdominal distension, was found, on endoscopy, to have a large sessile villous adenoma of the periampullary duodenum. Despite the lack of evidence of malignancy, a pancreaticoduodenectomy procedure was performed, mainly because of the tumor size and site, involving the ampulla of Vater. The presence of the carcinoma was diagnosed only in the resected specimen by definitive histology. Because there is no general consensus on the optimal surgical procedure for the treatment of villous tumors of the duodenum, especially for the early stages, the indications for the operative procedure are discussed, based on a review of the literature. 相似文献
87.
Guilarde AO Turchi MD Siqueira JB Feres VC Rocha B Levi JE Souza VA Boas LS Pannuti CS Martelli CM 《The Journal of infectious diseases》2008,197(6):817-824
BACKGROUND: Clinical manifestations of dengue vary in different areas of endemicity and between specific age groups, whereas predictors of outcome have remained controversial. In Brazil, the disease burden predominantly affects adults, with an increasing trend toward progression to dengue hemorrhagic fever (DHF) noted. METHODS: A cohort of adults with confirmed cases of dengue was recruited in central Brazil in 2005. Patients were classified according to the severity of their disease. Associations of antibody responses, viremia levels (as determined by real-time polymerase chain reaction [PCR]), and serotypes (as determined by multiplex PCR) with disease severity were evaluated. RESULTS: Of the 185 symptomatic patients >14 years of age who had a confirmed case of dengue, 26.5% and 23.2% were classified as having intermediate dengue fever (DF)/DHF (defined as internal hemorrhage, plasma leakage, manifested signs of shock, and/or thrombocytopenia [platelet count, < or =50,000 platelets/mm3]) and DHF, respectively. The onset of intermediate DF/DHF and DHF occurred at a late stage of disease, around the period of defervescence. Patients with DHF had abnormal liver enzyme levels, with a >3-fold increase in aspartate aminotransferase level, compared with the range of values considered to be normal. Overall, 65% of patients presented with secondary infections with dengue virus, with such infection occurring in similar proportions of patients in each of the 3 disease category groups. Dengue virus serotype 3 (DV3) was the predominant serotype, and viremia was detected during and after defervescence among patients with DHF or intermediate DF/DHF. CONCLUSIONS: Viremia was detected after defervescence in adult patients classified as having DHF or intermediate DF/DHF. Secondary infection was not a predictor of severe clinical manifestation in adults with infected with the DV3 serotype. 相似文献
88.
Carlsson B Hou M Giandomenico V Nilsson B Totterman TH Essand M 《The Journal of infectious diseases》2005,192(11):1912-1920
Cytomegalovirus (CMV) disease remains a severe complication in patients who have undergone transplantation. Viremia can be prevented and treated by the adoptive transfer of donor-derived CMV-directed T cells. To ensure long-term protection against CMV disease, it is important to transfer CMV antigen-specific T cells that represent both the CD8+ and the CD4+ subsets. In the present study, we used as stimulators dendritic cells (DCs) that were electroporated with in vitro-transcribed 5'-capped polyadenylated messenger RNA (mRNA) that encoded the CMV pp65 protein (i.e., pp65 mRNA). These DCs could efficiently activate CMV-directed CD8+ T cells, as assayed by tetramer staining, interferon- gamma production, and cytolytic activity. We also used DCs that were pulsed with a recombinant pp65 protein to activate CMV-directed CD4+ T cells. When DCs were comodified with pp65 mRNA and pp65 protein, large numbers of CMV-directed CD8+ and CD4+ T cells were generated simultaneously. The approach outlined in the present study can be adapted for a clinical protocol that circumvents potential virus-related biohazards and is available to all patients independently of their human leukocyte antigen haplotype. 相似文献
89.
Busca A Lovisone E Aliberti S Locatelli F Serra A Scaravaglio P Omedè P Rossi G Cirillo D Barbui A Ghisetti V Dall'Omo AM Falda M 《Hematology (Amsterdam, Netherlands)》2003,8(5):303-311
Non-myeloablative stem cell transplantation (NMT) has been increasingly used in compromised patients who would otherwise have been unable to undergo allotransplant. There is little understanding of the kinetics of immune reconstitution and its influence on infective complications following NMT. The aim of present study was to evaluate lymphocyte subset reconstitution over the first 12 months post-transplant in 15 adult patients receiving NMT with comparison to that of 30 patients grafted with a conventional hemopoietic stem cell transplantation (HSCT). NMT recipients were conditioned with fludarabine-based conditioning regimens. Peripheral blood stem cell (PBSC) was the source of stem cells in 13 NMT recipients and in 24 conventional HSCT recipients. Absolute numbers of helper (CD4+) T cells, naive (CD4+ CD45RA+) and memory (CD4+ CD45RO+) T cells as well as suppressor (CD8+) T cells, CD19+ B cells and NK cells were comparable in the two groups at all time points after transplantation. A median value of 200 CD4+ T cells/microl was achieved at 2 months post-transplant by the NMT and HSCT recipients. The CD4:CD8 ratio remained severely depressed throughout the study period. Almost all CD4+ lymphocytes expressed CD45RO antigen in the both groups of patients B lymphocytes showed low counts throughout the entire study period in both groups. Bacteremia and CMV antigenemia occurred respectively in 13 and 36% of the patients in the NMT group and in 15 and 39% of the patients in the HSCT group. Our preliminary data indicate that patients receiving a NMT have a lymphocyte reconstitution similar to that observed in patients who received a conventional HSCT. The incidence of bacteremia and CMV infection were not significantly different between the groups. Nevertheless, due to the small sample size, these results should be considered suggestive rather than definitive. 相似文献
90.
Garcia Cecilia C. Piotrkowski Bárbara Baz Plácida Poncino Daniel Benavides Javier Colombato Luis Toso María Laura Reyes Yantorno Silvina Descalzi Valeria Gondolesi Gabriel E. Fraga Cesar G. Cherñavsky Alejandra C. 《Digestive diseases and sciences》2022,67(7):3006-3016
Digestive Diseases and Sciences - Deregulation of immune response and oxidative stress contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. Resistin is a physiological modulator of... 相似文献