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排序方式: 共有546条查询结果,搜索用时 15 毫秒
61.
Terada R Yasutake T Yamaguchi E Hisamatsu T Nakamura S Ayabe H Tagawa Y 《Journal of gastroenterology》1999,34(1):11-17
We investigated the correlation between the frequency of numerical aberrations of chromosome 17 and clinicopathological features
of gastric cancer. The copy number of chromosome 17 was examined with fluorescence in-situ hybridization (FISH) in frozen
specimens from 100 primary gastric cancers. Chromosomal numerical aberrations were diagnosed as chromosomal loss (single signal)
or gain (triple or more signals), in each cell. The frequency of numerical aberrations of chromosome 17 correlated significantly
with the depth of invasion (P < 0.01), lymph node metastasis (P < 0.0001), lymphatic invasion (P < 0.001), and venous invasion (P < 0.01). Numerical aberrations of chromosome 17 were associated with lymph node metastasis in 32 early gastric cancers. Multiple
regression analysis identified the depth of invasion and numerical aberrations of chromosome 17 as independent significant
determinants of lymph node metastasis. Our findings suggest that alterations in chromosome 17 may be linked with tumor progression
in primary gastric cancer.
Our results also indicate that numerical aberrations of chromosome 17 detected by FISH provide important information about
the malignant potential (in particular, lymph node metastasis) of primary gastric cancer.
(Received Feb. 22, 1998; accepted July 24, 1998) 相似文献
62.
Yoshiaki Hamamoto Shinji Harada Naoki Yamamoto Yahiro Uemura Takashi Goto and Tadakazu Suyama 《Vox sanguinis》1987,53(2):65-69
More than 10(4) plaque-forming units (pfu)/ml of HIV are inactivated during the alcohol fractionation step from plasma to fraction (Fr)-II+III, greater than 10(4) pfu/ml is inactivated from Fr-II+III to Fr-II and greater than 10(4) pfu/ml is inactivated during the polyethylene glycol (PEG) fractionation process from Fr-II+III to intravenous IgG (IVIG). The total inactivation rate from plasma to IVIG via Fr-II+III or Fr-II was calculated to be greater than 10(8) or 10(12), respectively. The PEG fractionation method produces an intact and unmodified IVIG. In addition, the PEG fractionation method at a low ionic strength was found to be effective for the elimination of greater than 10(5) units of other viruses, including hepatitis B, vesicular stomatitis and Sindbis viruses. 相似文献
63.
Tsukamoto S Fujita S Yamaguchi T Yamamoto S Akasu T Moriya Y Taniguchi H Shimoda T 《International journal of colorectal disease》2008,23(11):1109-1113
Background To clarify the oncological outcome of rectal well-differentiated neuroendocrine tumors (W/D NETs), we examined the clinicopathological
characteristics and prognosis of patients with this neoplasm.
Materials and methods A total of 23 patients who underwent surgical treatment with lymph node dissection for rectal W/D NETs between 1973 and 2007
were reviewed.
Results Median tumor size measured preoperatively was 13 mm (range, 4–25 mm), and the median number of dissected lymph nodes was 16
(range, 1–46). The incidence of lymph node metastasis was 61% (14 of 23 cases). The smallest W/D NETs with lymph node metastasis
was 10 mm in diameter. All the patients without lymph node metastasis survived without recurrence. Among 11 patients who had
only regional lymph node metastasis, only one developed liver metastasis and died 13 months after initial surgery. Among three
patients with lateral pelvic lymph node metastasis, two survived more than 5 years, although two had liver metastasis.
Conclusions Because the incidence of lymph node metastasis is very high in patients with rectal W/D NETs greater than 10 mm in diameter,
radical surgery is required. In this series, the outcome of rectal W/D NETs patients with lateral pelvic lymph node metastasis
was better than expected. 相似文献
64.
Spontaneous perforation of a choledochal cyst with ensuing pseudocyst formation is a very rare complication. We report the development of a pseudocyst adjacent to a choledochal cyst in a very low-birth-weight infant at 2 months of age. Elective excision of the choledochal cyst and biliary tract reconstruction were successfully performed 2 months later when the infant weighed 3 kg. Delayed primary repair may be a viable alternative treatment for low-birth-weight infants with choledochal cysts. 相似文献
65.
A clinicopathological study of 9 cases presenting axillary mass alone was reported. Histological diagnosis revealed 3 occult breast cancers, 2 apocrine gland adenocarcinomas of the skin, a carcinoma and a fibroadenoma in the axillary accessory breast, a neurogenic tumor in the axilla, and a benign lymphadenopathy. There were no clinical characteristics helpful in preoperative differential diagnosis. As the axilla includes the main lymphatic routes from the breast, the axillary tail of the breast and accessory breast, breast-associated tumors should be kept in mind in the management of patients with axillary mass as a sole clinical feature. 相似文献
66.
Effects of intraperitoneal administration of OK-432 for patients with advanced cancer 总被引:1,自引:0,他引:1
T Toge H Yamada K Aratani A Kameda K Kuroi K Hisamatsu T Hattori 《The Japanese journal of surgery》1985,15(4):260-265
The effects of intraperitoneal administration of OK-432 on tumor cells in ascites, in relation to the infiltration of effector cells and on the immune responses of the host, particularly, with regard to immune suppressive mechanisms, were investigated in 25 patients with cancerous ascites. The effects of OK-432 depended on frequency of the repeated and continuous administrations through a tube placed in the peritoneum during laparotomy. Infiltrations of neutrophils and lymphocytes were observed in the ascites within a short period after the administration and monocyte infiltration followed. Disappearance of tumor cells correlated well with the infiltration of these cells. No marked changes in the proliferative responses of peripheral blood lymphocytes were noted and decreases in serum inhibitory factor levels in sera were observed in patients given larger doses of OK-432. A marked reduction in Concanavalin-A-induced suppressor cell activities was observed after OK-432 administration. OK-432 administration probably leads to a disappearance of tumor cells by enhancing peritoneal effector cell activities and by inhibiting the induction of suppressor cell activities, in a dose dependent manner. 相似文献
67.
H Shimizu M Yamasaki E Okamoto K Hisamatsu K Ohama 《Nippon Gan Chiryo Gakkai shi》1989,24(11):2569-2576
Twenty-five elderly women (those 70 years or older) with borderline and malignant ovarian tumors during the past 20 years were reviewed clinico-pathologically in comparison with 160 younger women (those 69 years or younger). The following results were obtained: 1) The incidence rate of elderly women for all patients of borderline and malignant ovarian tumors was 13.5%, and did not tend to increase in the past several years. 2) The rate that the elderly woman visited first at the other department excepting the department of obstetrics and gynecology was 36%, and which was statistically higher than that of the younger woman (p less than 0.01). 3) Fifty-two % of elderly patients had some complications and the incidence was significantly higher than that (23.1%) of younger patients (p less than 0.005). 4) Histopathologically in elderly patients, 9 patients (36%) were of serous cystadenocarcinoma and 17 patients (68%) were of malignant epithelial tumor (primary ovarian cancer and malignant Brenner tumor). 5) Of elderly patients, 8 (47.1%) were in Stage III and IV, and it was higher incidence than that (33.3%) of younger patients. In advanced cases, the histological grades became more poorly. 6) The survival rate of elderly patients in Stage III and IV was significantly lower than that in Stage I and II. The various treatment for Stage III and IV patients did not demonstrate the correlation in prognosis. In contrast, the survival rate for the group treated surgically in Stage I and II was significantly higher than that of non-surgical group (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
68.
69.
70.
Tsuchida K Chaki H Takakura T Kotsubo H Tanaka T Aikawa Y Shiozawa S Hirono S 《Journal of medicinal chemistry》2006,49(1):80-91
We designed and synthesized small-molecule activator protein-1 (AP-1) inhibitors based on a three-dimensional (3D) pharmacophore model that we had previously derived from a cyclic decapeptide exhibiting AP-1 inhibitory activity. New AP-1 inhibitors with a 1-thia-4-azaspiro[4.5]decane or a benzophenone scaffold, which inhibit the DNA-binding and transactivation activities of AP-1, were discovered using a "lead hopping" procedure. An additional investigation of the benzophenone analogues confirmed the reliability of the pharmacophore model, its utility to discover AP-1 inhibitors, and the potency of the benzophenone derivatives as a lead series. 相似文献