全文获取类型
收费全文 | 4583篇 |
免费 | 323篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 82篇 |
儿科学 | 114篇 |
妇产科学 | 45篇 |
基础医学 | 567篇 |
口腔科学 | 121篇 |
临床医学 | 360篇 |
内科学 | 1274篇 |
皮肤病学 | 31篇 |
神经病学 | 321篇 |
特种医学 | 191篇 |
外科学 | 799篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 113篇 |
眼科学 | 153篇 |
药学 | 244篇 |
中国医学 | 3篇 |
肿瘤学 | 505篇 |
出版年
2024年 | 8篇 |
2023年 | 89篇 |
2022年 | 41篇 |
2021年 | 312篇 |
2020年 | 152篇 |
2019年 | 167篇 |
2018年 | 191篇 |
2017年 | 144篇 |
2016年 | 178篇 |
2015年 | 156篇 |
2014年 | 174篇 |
2013年 | 239篇 |
2012年 | 369篇 |
2011年 | 418篇 |
2010年 | 201篇 |
2009年 | 138篇 |
2008年 | 236篇 |
2007年 | 243篇 |
2006年 | 203篇 |
2005年 | 198篇 |
2004年 | 169篇 |
2003年 | 170篇 |
2002年 | 160篇 |
2001年 | 23篇 |
2000年 | 31篇 |
1999年 | 36篇 |
1998年 | 32篇 |
1997年 | 26篇 |
1996年 | 26篇 |
1995年 | 29篇 |
1994年 | 30篇 |
1993年 | 19篇 |
1992年 | 36篇 |
1991年 | 24篇 |
1990年 | 26篇 |
1989年 | 29篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 21篇 |
1985年 | 14篇 |
1984年 | 16篇 |
1983年 | 15篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 11篇 |
1975年 | 12篇 |
1974年 | 16篇 |
排序方式: 共有4940条查询结果,搜索用时 561 毫秒
81.
Kenichi Kono Nagatsuki Tomura Ryo Yoshimura Tomoaki Terada 《Acta neurochirurgica》2013,155(8):1559-1563
Computational fluid dynamics (CFD) studies on cerebral aneurysms have attempted to identify surrogate hemodynamic parameters to predict rupture risk. We present a case of bilateral mirror image aneurysms, one of which ruptured soon after imaging. Wall shear stress values of the ruptured aneurysm changed by 20–30 % after rupture because of change in the aneurysm shape. Findings from our case suggest that CFD studies comparing unruptured and ruptured aneurysms may not yield valid estimation on aneurysm rupture risk because of changes in aneurysm shape after rupture. Changes in aneurysm shape after rupture should be considered in CFD research. 相似文献
82.
Impact of aldo‐keto reductase family 1 member B10 on the risk of hepatitis C virus‐related hepatocellular carcinoma 下载免费PDF全文
83.
Influence of different drilling preparation on cortical bone: A biomechanical,histological, and micro‐CT study on sheep 下载免费PDF全文
84.
85.
86.
87.
88.
Takehito Shukuya Ryo Atsuta Yoshiteru Morio Koichi Sato Tsutomu Suzuki Kuniaki Seyama Kazuhisa Takahashi 《Nihon Kokyūki Gakkai zasshi》2007,45(9):715-719
We report a case of pulmonary arteriovenous fistula with multiple hepatic arterioportal shunts. A 23-year-old man was admitted for evaluation of a nodular shadow in the right lower lung field. Chest CT showed a homogeneous and well-defined nodular shadow in the right S7. 3-dimensional CT revealed an arteriovenous fistula composed of a feeding artery and a draining vein in the right S7. Abdominal enhanced CT revealed a diffusely heterogeneous pattern in the liver parenchyma and the portal vein staining diffusely at the late arterial phase. We diagnosed pulmonary arteriovenous fistula associated with multiple hepatic arterioportal shunts. Pulmonary arteriovenous fistula is often associated with hereditary hemorrhagic telangiectasia (HHT). This case did not meet the criteria for HHT at this time. However, we could not exclude the possibility of HHT because clinical manifestations of HHT become apparent after 40 years old among 10% of patients. The natural history and treatment of HHT are not clear. We concluded that we should be careful to detect possible manifestations as HHT when we diagnose and follow up patients with pulmonary arteriovenous fistula. 相似文献
89.
Hiroi H Momoeda M Nakazawa F Koizumi M Tsutsumi R Hosokawa Y Osuga Y Yano T Tsutsumi O Taketani Y 《Endocrine journal》2008,55(1):183-189
Periostin/OSF2 is a ligand for alphavbeta3 and alphavbeta5 integrins and activates the Akt/PKB pathway. Recent reports of periostin/OSF2 gene disrupted mice indicate that periostin/OSF-2 plays an important role in implantation. Quantitative RT-PCR revealed that the expression of periostin/OSF-2 mRNA in rat uteri was reduced to approximately 10% at 12 h after 17beta-estradiol (E2) injection, but was not changed after progesterone (P) injection. RT-PCR revealed the expression of periostin/OSF-2 in human endometrium, cultured human endometrial stromal cells (ESCs), and cultured human endometrial epithelial cells. In ESCs, the expression of periostin/OSF-2 mRNA was reduced to approximately 50% at 6 h after E2 treatment. The amount of periostin/OSF2 mRNA in human endometrium significantly increased during mid-proliferative and early secretory phases of menstrual cycle, and decreased during late-proliferative, mid-secretory and late secretory phases. The expression of periostin/OSF2 mRNA significantly decreased in ESCs decidualized by treatment with E2 and P for 7 and 11 days. By immunohistochemistry, the expression of periostin/OSF-2 was strongly detected in endometrial stromal cells during early proliferative, mid-proliferative and early secretory phases, and was strongly detected in endometrial epithelial cells during late secretory phase. This study demonstrated that the expression of periostin/OSF-2 is regulated by ovarian steroid hormones in rat uterus and human endometrium. 相似文献
90.
Shiratori Y Kato N Yoshida H Nakata R Ihori M Imazeki F Yokosuka O Kawase T Katamoto T Unuma T Nakamura A Ikegami F Hirota K Omata M 《Digestive diseases and sciences》2000,45(3):565-574
Adequate dosing of interferon (IFN) and its cost-effectiveness for sustained virological response were evaluated in relation to viral load and subtype. Prospective analysis of IFN therapy on 326 patients with chronic hepatitis C free from cirrhosis was performed using 9 or 6 million unit (MU) of IFN for six months daily and/or three times a week. Sustained virological response was achieved in 50–94% of patients with 2 × 104 copies/ml (competitive RT-PCR) or <100 × 103 copies/ml (Amplicor monitor) of HCV RNA by 468–1206 MU of IFN, but response was only 0–25% of the patients with 2 × 105.5 copies/ml (competitive RT-PCR) or >200 × 103 copies/ml (Amplicor monitor), even with 468–1206 MU of IFN. A high sustained rate was demonstrated in patients with 100–200 × 103 copies/ml of HCV RNA by 901–1206 MU of IFN, in comparison to that with 900 MU of IFN. Multivariate analysis showed that IFN dose had a significant value for the efficacy of IFN therapy in patients presenting 100–200 × 103 copies/ml of HCV RNA. Cost efficacy analysis indicated that it cost approximately $10,000, $26,000, and $50,000–227,000 for one person-viral eradication in the patients with <100, 100–200, and >200 × 103 copies/ml, respectively. High-dose IFN is only cost effective in patients with intermediate viral loads, and IFN therapy could be recommended in patients with <200 × 103 copies/ml of HCV RNA. 相似文献