全文获取类型
收费全文 | 1071篇 |
免费 | 76篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 59篇 |
妇产科学 | 16篇 |
基础医学 | 129篇 |
口腔科学 | 49篇 |
临床医学 | 61篇 |
内科学 | 232篇 |
皮肤病学 | 27篇 |
神经病学 | 79篇 |
特种医学 | 30篇 |
外科学 | 186篇 |
综合类 | 27篇 |
预防医学 | 49篇 |
眼科学 | 36篇 |
药学 | 71篇 |
中国医学 | 5篇 |
肿瘤学 | 85篇 |
出版年
2023年 | 14篇 |
2022年 | 11篇 |
2021年 | 65篇 |
2020年 | 32篇 |
2019年 | 35篇 |
2018年 | 44篇 |
2017年 | 30篇 |
2016年 | 50篇 |
2015年 | 45篇 |
2014年 | 53篇 |
2013年 | 62篇 |
2012年 | 105篇 |
2011年 | 102篇 |
2010年 | 48篇 |
2009年 | 39篇 |
2008年 | 45篇 |
2007年 | 63篇 |
2006年 | 44篇 |
2005年 | 40篇 |
2004年 | 35篇 |
2003年 | 35篇 |
2002年 | 31篇 |
2001年 | 7篇 |
2000年 | 7篇 |
1999年 | 8篇 |
1998年 | 9篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 8篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1970年 | 2篇 |
1968年 | 1篇 |
1930年 | 1篇 |
1925年 | 1篇 |
1924年 | 1篇 |
1922年 | 1篇 |
排序方式: 共有1150条查询结果,搜索用时 16 毫秒
101.
A cohort of children with hair pulling as the presenting symptom was followed up to enhance clinical understanding of the nature of hair-pulling behaviour in childhood. Thirty-eight children were clinically assessed for a diagnosis of trichotillomania, co-morbidity, co-existing habits and other relevant factors. Intervention consisted of a combination of behavioural strategies, self-esteem work, supportive family approaches, attachment-focused parenting models and medication. In this group of children it was difficult to define their symptoms as a clinical diagnosis of trichotillomania, using ICD-1O/DSM-IV. This article concludes that hair pulling, as a symptom in children, is a heterogeneous condition. It is useful to approach this issue from a developmental perspective. Our data warrant reappraisal of the diagnosis of trichotillomania in childhood. We explore the framework of a developmental continuum to understand and manage the problem of hair pulling in childhood. 相似文献
102.
103.
104.
105.
Abdul Samad K Prasanna MK Akhar AP 《Indian journal of dermatology, venereology and leprology》2002,68(4):225-226
Sezary syndrome (SS), is described as the classical triad of pruritic erythroderma, lymphadenopathy, and presence of more than 10% of circulating Sezary cells in the peripheral blood. We report on unusual case of advanced cutaneous T - cell lymphoma with classical haematological and histopathological features of Sezary syndrome, but lacking the clinical features of erythroderma. A 66 year old man presented with asymptomatic multiple papules, plaques and nodules and with generalized lymphadenopathy. Peripheral smear showed more than 60% of Sezary cells. Skin and lymph node biopsy showed typical features of T-cell lymphoma and immunohistochemistry and CD marker studies showed the cells to be atypical T-lymphocytes. This unusual case is highlighted to denote that erythroderma need not be taken as a hard and fast criterion for diagnosing Sezary syndrome. 相似文献
106.
Saha Bhawesh Chandra Kumari Rashmi Kushumesh Rakhi Ambasta Anita Sinha Bibhuti Prasanna 《International ophthalmology》2022,42(1):281-294
International Ophthalmology - Medical management remains the cornerstone of glaucoma management despite advances in the surgical or laser procedures. After a leap of almost two decades of the... 相似文献
107.
PURPOSE: Temporal lobe epilepsy (TLE) in early life is often a catastrophic disorder with pharmacoresistant seizures and secondary neurological deterioration. there is little data available regarding epilepsy surgery performed in infants and young children and no prior study has focused on tle. METHODS: We analyzed the results of temporal resection for epilepsy as the primary indication in children less than age 5 years who had at least 2 years of follow-up. RESULTS: 20 children (14 males) were identified with a mean age at surgery of 26 months and a mean age at seizure onset of 12 months. Clinical presentation was diverse. Typical psychomotor seizures (n = 4; mean age at surgery 37 months) were followed by prominent motor changes (n = 7; 30 months) and were occasionally isolated (n = 3; 23 months). Epileptic spasms were noted in six patients and were frequently associated with lateralizing features. The interictal EEG was lateralizing in 15 patients and the ictal EEG was lateralizing in 18 patients. Brain MRI provided localizing value in 16 patients, ictal SPECT was concordant in 4/8 cases. Invasive EEG was employed in six cases. At mean follow-up of 5.5 years, 65% of the children were seizure-free and 15% had >90% seizure reduction. Morbidity included infection and hydrocephalus in one case and stroke-related hemiparesis in two cases. Cortical dysplasia was identified in eight children, tumors in eight including two DNET, two ganglioglioma, and four malignant tumors. Hippocampal sclerosis was present in four cases, always as dual pathology. CONCLUSION: TLE presents in early life with varied and severe manifestations. Excisional procedures in this age group are associated with favorable seizure reduction similar to older children and in adults. 相似文献
108.
Epilepsy surgery in patients with normal or nonfocal MRI scans: integrative strategies offer long-term seizure relief 总被引:1,自引:0,他引:1
Jayakar P Dunoyer C Dean P Ragheb J Resnick T Morrison G Bhatia S Duchowny M 《Epilepsia》2008,49(5):758-764
PURPOSE: Excisional surgery achieves seizure freedom in a large proportion of children with intractable lesional epilepsy, but the outcome for children without a focal lesion on MRI is less clear. We report the outcome of a cohort predominantly of children with nonlesional intractable partial epilepsy undergoing resective surgery. METHODS: We studied 102 patients with nonlesional intractable partial epilepsy who underwent excisional surgery. The epileptogenic region was identified by integrating clinical exam and video-EEG data complemented by ictal SPECT (n = 40), PET (n = 10), extraoperative subdural monitoring (n = 80), and electrocorticography (n = 22). All patients had follow-up greater than 2 years, 76 patients had 5-year follow-up, and 43 patients had 10-year follow-up. RESULTS: A total of 66 resections were unilobar; 36 were multilobar. One patient died of causes unrelated to seizures or surgery. At 2-year follow-up, 44 of 101 patients were seizure-free, 15 experienced >90% reduction, 17 had >50% reduction, and 25 were unchanged. At 5-year follow-up, 35 of 76 patients were seizure-free, 12 experienced >90% reduction, 12 had >50% reduction, and 17 were unchanged. At 10-year follow-up, 16 of 43 patients were seizure-free, 13 experienced >90% reduction, 7 had >50% reduction, and 7 were unchanged. Outcomes correlated with the presence of convergent focal interictal spikes (p < 0.005) on the scalp EEG and completeness of resection (p < 0.0005). CONCLUSIONS: Our findings demonstrate that excisional surgery is successful in the majority of children with nonlesional partial epilepsy. A multimodal integrative approach can minimize the size of resection and alleviate the need for invasive EEG monitoring. Focal interictal spikes and completeness of resection predict good outcome. The benefits of surgery are long-lasting. 相似文献
109.
Hakkalamani S Prasanna VK Wood EV Acharya A Parkinson RW 《The Journal of arthroplasty》2008,23(8):1140-1145
Stem dissociation in modular revision knee arthroplasty, due to failure of the frictional lock of the Morse taper, has previously been reported in the literature. The medium-term to long-term implications of stem dissociation are however unknown because the clinical outcomes have not been reported. We report a series of 10 cases of tibial-stem dissociation in the Coordinate revision knee system (DePuy, Warsaw, Ind). At an average follow-up of 8.1 years (range, 6-11 years), there was no detriment to the clinical outcome in 9 cases in which there was a contained bony defect. In one case in which there was a significant medial-tibial uncontained bony defect, there was a failure of the prosthesis, which necessitated re-revision arthroplasty surgery at 4 years. We therefore question whether long canal-filling tibial stems are necessary in all revision knee arthroplasties, particularly when there is a contained bone defect together with optimal alignment and adequate support of the prosthesis, and a non-constrained-polyethylene insert is used. 相似文献
110.
Intramedullary neurenteric cysts (NEC) without associated malformations are extremely rare and, to our knowledge, have never
been reported in association with calcification. We report a unique imaging presentation as a partially calcified mass of
an isolated intramedullary neuroenteric cyst of the lower thoracic spinal cord with pathologic correlation. The literature
for isolated forms of intramedullary NEC since the advent of magnetic resonance imaging is also reviewed. 相似文献