全文获取类型
收费全文 | 1455646篇 |
免费 | 108900篇 |
国内免费 | 2340篇 |
专业分类
耳鼻咽喉 | 20540篇 |
儿科学 | 49669篇 |
妇产科学 | 38788篇 |
基础医学 | 208514篇 |
口腔科学 | 38058篇 |
临床医学 | 126225篇 |
内科学 | 296030篇 |
皮肤病学 | 32668篇 |
神经病学 | 116675篇 |
特种医学 | 56762篇 |
外国民族医学 | 715篇 |
外科学 | 218573篇 |
综合类 | 27835篇 |
现状与发展 | 1篇 |
一般理论 | 429篇 |
预防医学 | 111949篇 |
眼科学 | 31255篇 |
药学 | 107815篇 |
3篇 | |
中国医学 | 2981篇 |
肿瘤学 | 81401篇 |
出版年
2021年 | 10771篇 |
2019年 | 12186篇 |
2018年 | 19083篇 |
2017年 | 13957篇 |
2016年 | 14899篇 |
2015年 | 16878篇 |
2014年 | 21874篇 |
2013年 | 33678篇 |
2012年 | 49301篇 |
2011年 | 51274篇 |
2010年 | 29235篇 |
2009年 | 26685篇 |
2008年 | 47901篇 |
2007年 | 51406篇 |
2006年 | 50530篇 |
2005年 | 49336篇 |
2004年 | 47738篇 |
2003年 | 45722篇 |
2002年 | 44486篇 |
2001年 | 67404篇 |
2000年 | 69945篇 |
1999年 | 59524篇 |
1998年 | 15844篇 |
1997年 | 14372篇 |
1996年 | 14787篇 |
1995年 | 13959篇 |
1994年 | 13242篇 |
1993年 | 12230篇 |
1992年 | 46545篇 |
1991年 | 45302篇 |
1990年 | 43918篇 |
1989年 | 41680篇 |
1988年 | 38411篇 |
1987年 | 37630篇 |
1986年 | 34930篇 |
1985年 | 33511篇 |
1984年 | 25058篇 |
1983年 | 21029篇 |
1982年 | 12196篇 |
1981年 | 11049篇 |
1979年 | 22131篇 |
1978年 | 15383篇 |
1977年 | 13050篇 |
1976年 | 12123篇 |
1975年 | 13189篇 |
1974年 | 15362篇 |
1973年 | 14823篇 |
1972年 | 13595篇 |
1971年 | 12324篇 |
1970年 | 11621篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
81.
Claire Letournel François Babinet Bénédicte Allard Vincent Montecot 《Néphrologie & thérapeutique》2019,15(1):51-58
Objective
The “Centre Hospitalier Francois Dunan” is located on an isolated island and ensures patients care in hemodialysis thanks to telemedicine support. Many research studies have demonstrated the importance of hemodialysis fluids composition to reduce morbidity in patients on chronic hemodialysis. The aim of this study was to identify the risks inherent in the production of dialysis fluids in a particular context, in order to set up an improvement action plan to improve risk control on the production of dialysis fluids.Methods
The risk analysis was conducted with the FMECA methodology (Failure Mode, Effects and Criticality Analysis) by a multi professional work group. Three types of risk have been reviewed: technical risks that may impact the production of hemodialysis fluids, health risks linked with chemical composition and health risks due to microbiological contamination of hemodialysis fluids.Results
The work group, in close cooperation with the expert staff of the dialysis center providing telemedicine assistance, has developed an action plan in order to improve the control of the main risks brought to light by the risk analysis.Conclusion
The exhaustive analysis of the risks and their prioritisation have permitted to establish a relevant action plan in this improving quality of dialysis fluids approach. The risk control of dialysis fluids is necessary for the security of dialysis sessions for patients, even more when these sessions are realized by telemedicine in Saint-Pierre-et-Miquelon. 相似文献82.
83.
Wenjing Tao Miia Artama My von Euler-Chelpin Mark Hull Rickard Ljung Elsebeth Lynge Guðríður H. Ólafsdóttir Eero Pukkala Pål Romundstad Mats Talbäck Laufey Tryggvadottir Jesper Lagergren 《International journal of cancer. Journal international du cancer》2020,147(3):728-735
Obesity is a risk factor for colorectal cancer. Yet, some research indicates that weight-reducing bariatric surgery also increases colorectal cancer risk. Our study was undertaken because current evidence examining bariatric surgery and risk of colorectal cancer is limited and inconsistent. This population-based cohort study included adults with a documented obesity diagnosis in Denmark, Finland, Iceland, Norway or Sweden in 1980–2015. The incidence of colorectal cancer in participants with obesity who had and had not undergone bariatric surgery was compared to the incidence in the corresponding background population by calculating standardized incidence ratios (SIR) with 95% confidence intervals (CI). Additionally, operated and nonoperated participants with obesity were compared using multivariable Cox regression, providing hazard ratios (HR) with 95% CIs adjusted for confounders. Among 502,772 cohort participants with an obesity diagnosis, 49,931(9.9%) underwent bariatric surgery. The overall SIR of colon cancer was increased after bariatric surgery (SIR 1.56; 95% CI 1.28–1.88), with higher SIRs ≥10 years postsurgery. The overall HR of colon cancer in operated compared to nonoperated participants was 1.13 (95% CI 0.92–1.39) and 1.55 (95% CI 1.04–2.31) 10–14 years after bariatric surgery. Bariatric surgery did not significantly increase the risk of rectal cancer (SIR 1.14, 95% CI 0.83–1.52; HR 1.08, 95% CI 0.79–1.49), but the risk estimates increased with longer follow-up periods. Our study suggests that bariatric surgery is associated with an increased risk of colon cancer, while the support for an increased risk of rectal cancer was weaker. 相似文献
84.
Hélène Person Francis Guillemin Thierry Conroy Michel Velten Christine Rotonda 《International journal of cancer. Journal international du cancer》2020,146(7):1827-1835
Women with breast cancer are increasingly being cured of the disease but fatigue remains the most frequently reported symptom. The aims of our study were to identify distinct trajectories in four fatigue dimensions during 2 years after breast cancer surgery and to explore the demographic, clinical and personality characteristics associated with these profiles. We included women from the prospective longitudinal multicenter FATSEIN cohort in France. They completed the Multidimensional Fatigue Inventory for nine follow-ups over 24 months after surgery. A group-based trajectory model identified distinct trajectories in each fatigue dimension. Multinomial logistic regression determined the factors associated with each profile. From the 459 women followed, 3–5 fatigue trajectories were revealed in each fatigue dimension, from its absence to its severest degree. In our multivariate analysis, the risk of severe fatigue was decreased in all dimensions by a high quality of life before surgery (measured by the European Organization for Research and Treatment of Cancer 30-item QoL questionnaire; e.g., for general and physical fatigue: OR = 0.93, 95% CI 0.91, 0.96), especially a high physical and emotional functions for general and physical fatigue, and a high cognitive function for mental fatigue. Both severe mental fatigue and severely reduced motivation worsened with low optimism before surgery (e.g., for mental fatigue: OR = 0.93, 95% CI 0.89, 0.97). Severely reduced activities increased by having chemotherapy (OR = 9.41, 95% CI 2.28, 38.79). Targeting women at risk for severe fatigue can provide early preventive and curative treatment and appropriate psychological support. 相似文献
85.
86.
87.
Rishad R. Jivani Gaurang J. Lakhtaria Dhaval D. Patadiya Laxman D. Patel Nurrudin P. Jivani Bhagyesh P. Jhala 《Saudi Pharmaceutical Journal》2016,24(1):1-20
Advancement in microelectromechanical system has facilitated the microfabrication of polymeric substrates and the development of the novel class of controlled drug delivery devices. These vehicles have specifically tailored three dimensional physical and chemical features which together, provide the capacity to target cell, stimulate unidirectional controlled release of therapeutics and augment permeation across the barriers. Apart from drug delivery devices microfabrication technology’s offer exciting prospects to generate biomimetic gastrointestinal tract models. BioMEMS are capable of analysing biochemical liquid sample like solution of metabolites, macromolecules, proteins, nucleic acid, cells and viruses. This review summarized multidisciplinary application of biomedical microelectromechanical systems in drug delivery and its potential in analytical procedures. 相似文献
88.
89.
In the 6th Basic Plan for Long-Term Electricity Supply and Demand (6th BPE) for Korea, for the first time, the environmental costs of air pollution caused by oxides of sulfur (SOx), oxides of nitrogen (NOx), and particulate matters (PM) from power plants were estimated and included. However, several deficiencies in evaluating the environmental costs were found. In this study, (1) the validity of the environmental costs used in the 6th BPE was assessed, (2) a systematic approach was suggested and used to improve the environmental costs estimation, and (3) the sensitivity of the cost of generating electricity to the environmental costs by fuel type with the proposed approach was discussed. We found that the applied environmental costs used in the 6th BPE did not fully include the demographic characteristics of Korea. By applying more realistic parameter values, it was found that the newly estimated environmental cost was about 23 times higher than the cost estimated in the original 6th BPE for coal-fired power plants and about 1.5 times higher for liquefied natural gas (LNG)-fired power plants, suggesting that LNG-fired power plants are more economical if using more realistic environmental costs. Thus, it is critical to check the validity of parameter values when calculating environmental costs. 相似文献
90.