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排序方式: 共有419条查询结果,搜索用时 15 毫秒
411.
Gliosarcoma is an uncommon variant of glioblastoma multiforme, which is composed of gliomatous and sarcomatous elements. The tumor is rarely encountered in childhood. This case report presents the magnetic resonance imaging characteristics of a giant gliosarcoma in a 3-year-old girl. Size and location of the tumor are described. 相似文献
412.
Chianese-Bullock KA Irvin WP Petroni GR Murphy C Smolkin M Olson WC Coleman E Boerner SA Nail CJ Neese PY Yuan A Hogan KT Slingluff CL 《Journal of immunotherapy (Hagerstown, Md. : 1997)》2008,31(4):420-430
Nine participants with epithelial ovarian, fallopian tube, or primary peritoneal carcinoma, who were human leukocyte antigen (HLA)-A1, HLA-A2, or HLA-A3, were eligible to enroll in a phase 1 study designed to assess the safety and immunogenicity of a peptide-based vaccine. Participants received 5 class I major histocompatibility complex-restricted synthetic peptides derived from multiple ovarian cancer-associated proteins plus a class II major histocompatibility complex-restricted synthetic helper peptide derived from tetanus toxoid protein. The vaccines were administered with granulocyte macrophage-colony stimulating factor in Montanide ISA-51 adjuvant over a 7-week period. All vaccine-related toxicities were grade 1 to 2, the most common being injection site reaction (grade 2, 100%), fatigue (grade 1, 78%), and headache (grade 1, 67%). Lymphocytes from the peripheral blood and a node draining a secondary vaccine site (sentinel immunized node) were harvested during the course of vaccination and T-cell responses to the peptides were evaluated using an enzyme-linked immunosorbent spot assay. CD8 T-cell responses were detected in 1 participant ex vivo and in 8 of 9 participants (89%) after in vitro stimulation. All 4 HLA-A2 and HLA-A3-restricted peptides were immunogenic. This includes 2 peptides, folate binding protein (FBP191-199) and Her-2/neu754-762, which had not previously been evaluated in vaccines in humans. Responding T cells required over 200 nM for half-maximal reactivity. These data support continued investigation of these peptides as immunogens for patients with ovarian cancer but, owing to low potency, also suggest a need for additional immunomodulation in combination with vaccines to increase the magnitude and to improve the quality of the T-cell responses. 相似文献
413.
Wood LJ Nail LM Perrin NA Elsea CR Fischer A Druker BJ 《Biological research for nursing》2006,8(2):157-169
Cancer chemotherapy-related symptoms such as fatigue, malaise, loss of interest in social activities, difficulty concentrating, and changes in sleep patterns can lead to treatment delays, dose reductions, or termination and have a profound effect on the physical, psychosocial, and economic aspects of quality of life. Clinicians have long suspected that these symptoms are similar to those associated with "sickness behavior," which is triggered by the production of the inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 by macrophages and other cells of the innate immune system in response to immune challenge. The p38 mitogen-activated protein kinase (p38 MAPK) plays a central role in the production of these cytokines and consequently the induction of sickness behavior. Several cancer chemotherapy drugs have been shown to activate p38 MAPK, but whether these drugs can also induce the production of inflammatory cytokines to cause sickness behavior is unknown. The aim of this study was to determine whether the cancer chemotherapy drug etoposide (VP-16), which is known to activate p38 MAPK, could induce inflammatory cytokine production by murine macrophages and sickness-like behaviors when injected into mice. VP-16 activated p38 MAPK and induced IL-6 production in murine macrophages in a p38 MAPK- dependent manner. VP-16 administration rapidly increased serum levels of IL-6 in healthy mice and induced sickness-like behaviors as evidenced by a decrease in food intake, body weight, hemoglobin level, and voluntary wheel-running activity. These findings support the idea that the induction of IL-1beta, TNF-alpha, and IL-6 by cancer chemotherapy drugs underlies the fatigue and associated symptoms experienced by people undergoing cancer chemotherapy. 相似文献
414.
The present study explored the constructs of sociotropy and autonomy with a group of Turkish depressed inpatients, who were administered the Beck Depression Inventory, the Dysfunctional Attitudes Scale, the Automatic Thoughts Questionnaire, and the Sociotropy-Autonomy Scale. A comparison group of students from three SES levels also were included in the study. Comparisons were made on the scale scores among the non-dysphoric students, the dysphoric students, and the depressed patients. The results seem to support the relationship of sociotropy with other depression measures in both samples. However, several problems were encountered with the construct autonomy as it is conceptualized in the Sociotropy-Autonomy Scale. 相似文献
415.
Vedat Hamuryudan Yilmaz
zyazgan Nail Hizli Cem Mat Sebahattin Yurdakul Yalin Tüzün Mustafa lenocak Hasan Yazici 《Arthritis \u0026amp; Rheumatology》1997,40(4):769-774
Objective. To assess the effect of azathioprine (AZA) treatment on long-term prognosis in Behçet's syndrome. Methods. Patients (all male) who took part in a double-blind, placebo-controlled trial of AZA a mean ± SD of 94 ± 10 months previously were reevaluated. Results. The emergence of blindness (log rank χ2 = 5.6, P = 0.02) and a 2-line drop in the visual acuity of the right eye (log rank χ2 = 5.9, P = 0.015) occurred significantly more frequently among the patients originally allocated to the placebo group compared with patients who originally received AZA, despite posttrial treatment for patients in both groups when needed. There was also a trend toward more frequent occurrence of extraocular complications in the placebo group. The beneficial effect of AZA was especially pronounced among patients who had eye involvement of short duration prior to their entry into the trial. Conclusion. Early treatment with AZA tends to favorably affect the long-term prognosis of Behçet's syndrome. 相似文献
416.
Nail Kahraman MD Dursun Topal MD Ayşe Merve Altunal MD Selma Kenar Tiryakioğlu MD Temmuz Taner MD Deniz Demir MD Mustafa Levent Çetin MD 《Echocardiography (Mount Kisco, N.Y.)》2023,40(1):51-56
Mitral aortic intervalvular fibrosa or aorto-mitral curtain is a fibrous avascular skeletal structure located between the anterior leaflet of the mitral valve and the non-coronary and left coronary cusps of the aortic valve. Mitral and aortic valve endocarditis are rarely accompanied by mitral aortic intervalvular fibrosa pseudoaneurysm and left atrial fistula of the aorta. Pseudoaneurysm of mitral aortic intervalvular fibrosa is a fatal complication that can occur after valvular surgery, valvular endocarditis, or blunt trauma. In this article, reconstructive surgical management with the Commando technique of a case who developed mitral-aortic intervalvular fibrosa pseudoaneurysm to left atrial fistula after aortic and mitral prosthetic valve endocarditis is described. The important feature of this article is that it is a first in the literature as it is accompanied by persistent left superior vena cava. 相似文献
417.
Nail Kahraman MD Dursun Topal MD Gültekin Coşkun MD Selma Kenar Tiryakioğlu MD Serra Topal MD Ayşe Merve Altunal MD Nöfel Ahmet Binicier MD Deniz Demir MD 《Echocardiography (Mount Kisco, N.Y.)》2023,40(3):279-284
Left ventricular outflow stenosis can develop at the supravalvular, valvular, and subvalvular levels. Resection of strictures at the diffuse subvalvular level is very difficult. In such pathologies, Konno-Rastan procedure provides very successful solutions as an anterior aortoventriculoplasty method. In this article, we performed anterior aortaventriculoplasty surgical treatment for tunnel type left ventricular outflow tract stenosis, recurrent subvalvular discrete membrane, and aortic regurgitation in an adult patient with a history of partial atrioventricular septal defect repair and subvalvular discrete membrane resection operation in early childhood. The Konno-Rastan procedure, which we applied to the redo case, which is rarely used in adult patients and rarely seen in the literature, is shared. 相似文献
418.
Nail Kahraman MD Dursun Topal MD Gültekin Coşkun MD Selma Kenar Tiryakioğlu MD Serra Topal MD Sena Güler MD Nöfel Ahmet Binicier MD Fatih Koca MD Deniz Demir MD 《Echocardiography (Mount Kisco, N.Y.)》2023,40(4):359-363
Among masses involving the mitral valve and annulus, caseous calcification of the mitral annulus (CCMA) is a rare disease. CCMA accounts for .63% of all mitral annular calcification (MAC) cases. The pathophysiology is still unknown. The correct diagnosis and treatment of this disease is very important to prevent complications. We present a case of giant CCMA with advanced mitral stenosis and hypertrophic cardiomyopathy, presenting with symptoms of infection and therefore a preliminary diagnosis of infective endocarditis. Because of these features, we wanted to share our case as it is the 1st case in the literature. 相似文献