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31.
Benjamin Feiner Fuad Fares Nail Azam Ron Auslender Miriam David Yoram Abramov 《International urogynecology journal》2009,20(9):1061-1065
Introduction and hypothesis COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association
exists with pelvic organ prolapse (POP).
Methods Patients with advanced prolapse and healthy controls were evaluated by interview, validated questionnaires, and pelvic examination.
DNA was extracted from peripheral blood, and polymerase chain reaction was performed to determine the presence or absence
of the polymorphism. Power calculation indicated the need for 36 patients in each arm.
Results The prevalence of the polymorphic heterozygous genotype (GT) in the study and control groups was 33.3% and 19.4%, respectively,
leading to an odds ratio of 1.75. This difference, however, did not reach statistical significance (p = 0.27).
Conclusions The COLIA1 polymorphism was not significantly associated with increased risk for POP. 相似文献
32.
The purpose of this study was to perform a rapid determination of vial heat transfer parameters, that is, the contact parameter K(cs) and the separation distance l(v), using the sublimation rate profiles measured by tunable diode laser absorption spectroscopy (TDLAS). In this study, each size of vial was filled with pure water followed by a freeze-drying cycle using a LyoStar II dryer (FTS Systems) with step-changes of the chamber pressure set-point at to 25, 50, 100, 200, 300, and 400 mTorr. K(cs) was independently determined by nonlinear parameter estimation using the sublimation rates measured at the pressure set-point of 25 mTorr. After obtaining K(cs), the l(v) value for each vial size was determined by nonlinear parameter estimation using the pooled sublimation rate profiles obtained at 25 to 400 mTorr. The vial heat transfer coefficient K(v), as a function of the chamber pressure, was readily calculated, using the obtained K(cs) and l(v) values. It is interesting to note the significant difference in K(v) of two similar types of 10 mL Schott tubing vials, primary due to the geometry of the vial-bottom, as demonstrated by the images of the contact areas of the vial-bottom. 相似文献
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Introduction We describe the magnetic resonance (MR) imaging characteristics of dysembryoplastic neuroepithelial tumors (DNT) and discuss
their differential diagnosis.
Material and methods Proton MR spectroscopy (TE 30 and 136 ms), diffusion-weighted and perfusion images were retrospectively evaluated in 22 patients
with pathologically proven DNT (17 male and 5 female, mean age 18.7 years) and 14 control subjects (10 male and 4 female,
mean age 16.9 years). The results from the DNT patients and from the control subjects were compared using an independent sample
t-test and the degree of correlation was tested by Pearson’s correlation.
Results All DNTs were solitary and in a supratentorial cortical or subcortical location (ten temporal, eight frontal and four parietal).
They had low-signal on T1-weighted images and high-signal on T2-weighted images without a prominent mass effect. Additionally
a cystic appearance (six patients, 27.3%), cortical dysplasia (six patients, 27.3%) and contrast enhancement (four patients,
18.2%) were also noted. No significant differences were detected in NAA/Cho, NAA/Cr, NAA/Cho+Cr or Cho/Cr ratios between DNT
and normal brain. DNTs had a significantly higher mI/Cr ratio and apparent diffusion coefficient (ADC) values and lower cerebral
blood values than normal parenchyma (P < 0.001). ADC had the highest correlation with the diagnosis of DNT (r = 0.996) followed by relative cerebral blood volume (rCBV) (r = −0.883) and mI/Cr ratio (r = 0.663).
Conclusion Proton MR spectroscopy, diffusion-weighted and perfusion imaging characteristics of DNTs provide additional information to
their MR imaging findings. The MR spectrum showing a slight increase in mI/Cr ratio, and higher ADC and lower rCBV values
than normal parenchyma help to differentiate DNTs from other cortical tumors, which had higher rCBV and lower ADC values than
DNTs.
This work was presented at the ASNR 45th Annual Meeting 2007. 相似文献
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35.
Oculogyric crisis (OGC) is an underrecognized oculodystonic reaction associated with several medications including carbamazepine. The authors present a patient who had presented to the emergency department on multiple occasions with a questionable ventriculoperitoneal (VP) shunt dysfunction. Symptoms included nausea, vomiting, altered level of consciousness, ataxia, and vertical eye deviation. The patient underwent multiple revisions of the VP shunt with transient and questionable improvement. During her visit to the neurology clinic, OGC from carbamazepine was suspected, and the dose was reduced. The patient has been completely asymptomatic for the past 18 months. The authors report this case to increase the awareness of carbamazepine-induced OGC as one of the differential diagnoses for VP shunt dysfunction. 相似文献
36.
Traumatic epidural hematomas of the posterior cranial fossa 总被引:1,自引:0,他引:1
Karasu A Sabanci PA Izgi N Imer M Sencer A Cansever T Canbolat A 《Surgical neurology》2008,69(3):247-51; dicussion 251-2
BACKGROUND: Traumatic EDHs of the posterior cranial fossa are rare and have a higher mortality than supratentorial localizations. Early diagnosis of TEHPCF and prompt surgical evacuation provide excellent recovery. Active use of cranial CT scanning has taken a major role in the diagnosis, surgical indication, close observation, and strategy planning. As a result, better prognosis is achieved. In this study, we represent our results and experiences in the management of TEHPCF. METHODS: Between 1993 and 2006, 65 patients with TEHPCF were treated in Istanbul University Faculty Of Medicine, Neurosurgery and Emergency Surgery Departments. The hospital records of these patients were analyzed retrospectively. RESULTS: Of 65 patients, whose diagnosis and management decisions were determined by cranial CT scans, 53 were treated through surgery and 12 by conservative methods. Of the 53 surgically treated patients, 2 (3%) patients died, and 2 (3%) other patients remained moderately disabled during their discharge. As a result, 61 (94%) of 65 patients had excellent recovery. CONCLUSION: When compared with the literature, our mortality rate was superior to other previously reported studies. In our opinion, this is a result of extensive use of the cranial CT scan together with aggressive surgery. Patients with occipital trauma should be evaluated using cranial CT scans, and those showing mass effect should be immediately treated surgically. The patients that have no mass effect on CT scans can be closely observed by planned serial control CT scans. 相似文献
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Before autonomy in nursing practice can become a reality, nurses must clearly identify their roles. This role identification is no easy task given the impact of significant changes taking place in acute care hospitals and the various levels of nursing practice found in most institutions. The authors advocate using middle managers and a committee of nurses with various interests and educational preparations to study the issues and reach a consensus as to the role of nursing. As the work of different hospital groups is shared with others, autonomous nursing practice will be a step closer to reality. 相似文献