全文获取类型
收费全文 | 2403篇 |
免费 | 140篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 50篇 |
妇产科学 | 68篇 |
基础医学 | 384篇 |
口腔科学 | 88篇 |
临床医学 | 225篇 |
内科学 | 576篇 |
皮肤病学 | 58篇 |
神经病学 | 227篇 |
特种医学 | 30篇 |
外科学 | 219篇 |
综合类 | 11篇 |
一般理论 | 2篇 |
预防医学 | 220篇 |
眼科学 | 17篇 |
药学 | 185篇 |
中国医学 | 6篇 |
肿瘤学 | 176篇 |
出版年
2023年 | 37篇 |
2022年 | 55篇 |
2021年 | 156篇 |
2020年 | 73篇 |
2019年 | 105篇 |
2018年 | 105篇 |
2017年 | 76篇 |
2016年 | 69篇 |
2015年 | 85篇 |
2014年 | 114篇 |
2013年 | 153篇 |
2012年 | 248篇 |
2011年 | 240篇 |
2010年 | 116篇 |
2009年 | 98篇 |
2008年 | 140篇 |
2007年 | 146篇 |
2006年 | 127篇 |
2005年 | 100篇 |
2004年 | 108篇 |
2003年 | 82篇 |
2002年 | 58篇 |
2001年 | 9篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 9篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1964年 | 1篇 |
1959年 | 2篇 |
排序方式: 共有2559条查询结果,搜索用时 203 毫秒
71.
72.
José Albuquerque de Figueiredo Neto Lívia Mariane Castelo Branco Reis Márcia Rodrigues Veras Lorena Lauren Chaves Queiroz Karine de Paiva Lima Nogueira Nunes Priscylla de Oliveira Miranda Alexsandro Ferreira dos Santos Joana Kátya Veras Rodrigues Sampaio Nunes 《Brazilian Journal Of Cardiovascular Surgery》2015,30(6):626-630
INTRODUCTION
The elderly population is growing rapidly. Political and socio-economic changes led to the demographic transition in this population with the highest number of surgeries and as well as many comorbidities.OBJECTIVE
To evaluate the impact of cardiovascular intervention on quality of life of elderly patients after three and six months.METHODS
Analytical prospective cohort study with elderly between 60 and 80 years of age, of both sexes, with a diagnosis of coronary artery disease and underwent cardiovascular intervention during the period June 2010 to June 2011. Data were collected by individual interviews in the pre and postoperative periods (after three and six months) by telephone. We used the SF-36 to analyse quality of life in order to assess the physical and mental health of the study population.RESULTS
Of the 44 individuals evaluated, 59.1% were men, 75% in the range of 65 to 74 years, 38.6% were white and 38.6% were black, 31.8% were uneducated, 43.2% were married and 68.2% had less than a minimum wage. Prevailed patients: non-diabetics (68.2%), non-obese (81.8%), hypertensive (84.1%), non-alcoholic and non-smokers (68.2% and 61.4%, respectively). A significant increase in the average of the SF-36 scores between pre and post-surgical periods (three and six months) for the domains: functional capacity, pain, general health, vitality and emotional aspect.CONCLUSION
The elderly population undergoing intervention may have cardiovascular benefits and improvements of quality of life. Physical fitness improvement measures can be taken to resume that capability. 相似文献73.
74.
Alessandro Martorana Francesco Di Lorenzo Lorena Belli Giuseppe Sancesario Sofia Toniolo Fabrizio Sallustio Giulia Maria Sancesario Giacomo Koch 《CNS Neuroscience & Therapeutics》2015,21(12):921-925
Impaired amyloid beta (Aβ) metabolism is currently considered central to understand the pathophysiology of Alzheimer's disease (AD). Measurements of cerebrospinal fluid Aβ levels remain the most useful marker for diagnostic purposes and to individuate people at risk for AD. Despite recent advances criticized the direct role in neurodegeneration of cortical neurons, Aβ is considered responsible for synaptopathy and impairment of neurotransmission and therefore remains the major trigger of AD and future pharmacological treatment remain Aβ oriented. However, experimental and clinical findings showed that Aβ peptides could have a wider range of action responsible for cell dysfunction and for appearance of clinico‐pathological entities different from AD. Such findings may induce misunderstanding of the real role played by Aβ in AD and therefore strengthen criticism on its centrality and need for CSF measurements. Aim of this review is to discuss the role of CSF Aβ levels in light of experimental, clinical pathologic, and electrophysiological results in AD and other pathological entities to put in a correct frame the value of Aβ changes. 相似文献
75.
76.
77.
78.
Silvana Daher Costa Geraldo Bezerra da Silva Jr. Camilla Neves Jacinto Lorena Vasconcelos Mesquita Martiniano Yago Sucupira Amaral Fernando Jose Villar Nogueira Paes Maria Luiza De Mattos Brito Oliveira Sales Ronaldo de Matos Esmeraldo Elizabeth De Francesco Daher 《The American journal of tropical medicine and hygiene》2015,93(2):394-396
Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions. The objective of this study was to identify evidence of RVFV exposure in Bodhei Village in a forested area at the edge of the RVFV-epidemic Garissa region. In a household cluster-based survey conducted between epidemics in early 2006, 211 participants were enrolled. Overall seroprevalence for anti-RVFV was high (18%) and comparable with rates in the more arid, dense brush regions farther north. Seroprevalence of adults was 28%, whereas that of children was significantly lower (3%; P < 0.001); the youngest positive child was age 3 years. Males were more likely to be seropositive than females (25% versus 11%; P < 0.01), and animal husbandry activities (birthing, sheltering, and butchering) were strongly associated with seropositivity. The results confirm that significant RVFV transmission occurs outside of recognized high-risk areas and independent of known epidemic periods. 相似文献
79.
80.
Héctor Eloy Tamez-Pérez Dania Lizet Quintanilla-Flores René Rodríguez-Gutiérrez José Gerardo González-González Alejandra Lorena Tamez-Pe?a 《World journal of diabetes》2015,6(8):1073-1081
Steroids are drugs that have been used extensively in a variety of conditions. Although widely prescribed for their anti-inflammatory and immunosuppressive properties, glucocorticoids have several side effects, being hyperglycemia one of the most common and representative. In the present review, we discuss the main epidemiologic characteristics associated with steroid use, with emphasis on the identification of high risk populations. Additionally we present the pathophysiology of corticosteroid induced hyperglycemia as well as the pharmacokinetics and pharmacodynamics associated with steroid use. We propose a treatment strategy based on previous reports and the understanding of the mechanism of action of both, the different types of glucocorticoids and the treatment options, in both the ambulatory and the hospital setting. Finally, we present some of the recent scientific advances as well as some options for future use of glucocorticoids. 相似文献