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排序方式: 共有2544条查询结果,搜索用时 500 毫秒
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Wilma Barcellini Anna Zaninoni Anna I. Gregorini Giulia Soverini Lorena Duca Bruno Fattizzo Juri A. Giannotta Patrizia Pedrotti Cristina Vercellati Anna P. Marcello Elisa Fermo Paola Bianchi Maria Domenica Cappellini 《British journal of haematology》2019,185(3):523-531
Iron overload (IO) is poorly investigated in the congenital haemolytic anaemias (CHAs), a heterogeneous group of rare inherited diseases encompassing abnormalities of the erythrocyte membrane and metabolism, and defects of the erythropoiesis. In this study we systematically evaluated routine iron parameters and cardiac and hepatic magnetic resonance imaging, together with erythropoietin, hepcidin, non-transferrin bound iron (NTBI), and cytokine serum levels in patients with different CHAs. We found that 40% of patients had a liver iron concentration (LIC) >4 mg Fe/g dry weight. Hepatic IO was associated with ferritin levels (P = 0·0025), transferrin saturation (TfSat, P = 0·002) and NTBI (P = 0·003). Moreover, ferritin >500 μg/l plus TfSat >60% was demonstrated as the best combination able to identify increased LIC, and TfSat alteration as more important in cases with discordant values. Possible confounding factors, such as transfusions, hepatic disease, metabolic syndrome and hereditary haemochromatosis-associated mutations, had negligible effects on IO. Erythropoietin and hepcidin levels were increased in CHAs compared with controls, correlating with LIC and ferritin, respectively. Regarding cytokines, γ-interferon (IFN-γ) was increased, and both interleukin 6 and IFN-γ levels positively correlated with ferritin and hepcidin levels. Overall, these findings suggest the existence of a vicious cycle between chronic haemolysis, inflammatory response and IO in CHAs. 相似文献
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Sevilla-Cermeño Laura Rautio Daniel Andrén Per Hillborg Maria Silverberg-Morse Maria Lahera Guillermo Mataix-Cols David Fernández de la Cruz Lorena 《European child & adolescent psychiatry》2020,29(9):1289-1299
European Child & Adolescent Psychiatry - Pediatric body dysmorphic disorder (BDD) is challenging to treat. This study aimed to establish the prevalence of insomnia in youth with BDD and explore... 相似文献
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Gorka Larrinaga Lorena Blanco Peio Errarte Maider Beitia Bego?a Sanz Itxaro Perez Amaia Irazusta Clara E. Sánchez Francisco Santaolalla Leire Andrés José I. López 《Disease markers》2013,35(6):825-832
Background. Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis/prognosis of these diseases. However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland. Methods. The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues. Results. The activity of DPPIV/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues. Aspartyl aminopeptidase (AspAP), alanyl aminopeptidase (AlaAP), prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues. AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH. Conclusions. These data suggest the involvement of DPPIV/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA. Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis/prognosis of thyroid neoplasms. 相似文献
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Andrea Grosso Lorena Charrier Emanuela Lovato Claudio Panico Cesare Mariotti Giancarlo Dapavo Roberto Chiuminatto Roberta Siliquini Maria Michela Gianino 《International ophthalmology》2014,34(2):217-223
Small-gauge vitreoretinal techniques have been shown to be safe and effective in the management of a wide spectrum of vitreoretinal diseases. However, the costs of the new technologies may represent a critical issue for national health systems. The aim of the study is to plan a Health Technology Assessment (HTA) by performing a comparative analysis between the 23- and 25-gauge techniques in the management of macular diseases (epiretinal membranes, macular holes, vitreo-macular traction syndrome). In this prospective study, 45–80-year-old patients undergoing vitrectomy surgery for macular disease were enrolled at the Torino Eye Hospital. In the HTA model we assessed the safety, clinical effectiveness, and cost and financial evaluation of 23-gauge compared with 25-gauge vitrectomies. Fifty patients entered the study; 14 patients underwent 23-gauge vitrectomy and 36 underwent 25-gauge vitrectomy. There was no statistically significant difference in post-operative visual acuity at 1 year between the two groups. No cases of retinal detachment or endophtalmitis were registered at 1-year follow-up. The 23-gauge technique was slightly more expensive than the 25-gauge: the total surgical costs were EUR1217.70 versus EUR1164.84 (p = 0.351). We provide a financial comparison between new vitreoretinal procedures recently introduced in the market and reimbursed by the Italian National Health System and we also stimulate a critical debate about the expensive technocratic model of medicine. 相似文献
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Frederico Figueiredo Amancio Maira Alves Pereira Felipe Campos de Melo Iani Lorena D'anuncia??o Jorge Luís Carvalho de Almeida Janer Aparecida Silveira Soares Marcela Lencine Ferraz Thiago Cardoso Vale José Roberto Lambertucci Mariangela Carneiro 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(3):267-270
Dengue is currently a major public-health problem. Dengue virus (DENV) is
classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4
was again detected in Brazil in 2010 in Roraima State, and one year later, the virus
was identified in the northern Brazilian states of Amazonas and Pará, followed by Rio
de Janeiro and São Paulo. In Minas Gerais, the first confirmed case of DENV-4
occurred in the municipality of Frutal in 2011 and has now been isolated from a
growing number of patients. Although DENV-2 is associated with the highest risk of
severe forms of the disease and death due to the infection, DENV-4 has also been
associated with severe forms of the disease and an increasing risk of hemorrhagic
manifestations. Herein, the first fatal case of confirmed DENV-4 in Brazil is
reported. The patient was an 11-year-old girl from the municipality of Montes Claros
in northern Minas Gerais State, Brazil. She had idiopathic thrombocytopenic purpura
as a comorbid condition and presented with a fulminant course of infection, leading
to death due to hemorrhagic complications. Diagnosis was confirmed by detection of
Dengue-specific antibodies using IgM capture enzyme-linked immunosorbent assay and
semi-nested RT-PCR. Primary care physicians and other health-care
providers should bear in mind that DENV-4 can also result in severe forms of the
disease and lead to hemorrhagic complications and death, mainly when dengue infection
is associated with coexisting conditions. 相似文献