全文获取类型
收费全文 | 189篇 |
免费 | 11篇 |
专业分类
儿科学 | 32篇 |
基础医学 | 5篇 |
口腔科学 | 1篇 |
临床医学 | 32篇 |
内科学 | 63篇 |
皮肤病学 | 1篇 |
神经病学 | 8篇 |
外科学 | 44篇 |
综合类 | 4篇 |
药学 | 5篇 |
肿瘤学 | 5篇 |
出版年
2021年 | 1篇 |
2017年 | 1篇 |
2016年 | 6篇 |
2015年 | 9篇 |
2014年 | 5篇 |
2013年 | 6篇 |
2012年 | 1篇 |
2010年 | 5篇 |
2009年 | 5篇 |
2007年 | 4篇 |
2006年 | 22篇 |
2005年 | 10篇 |
2004年 | 6篇 |
2003年 | 9篇 |
2002年 | 4篇 |
2001年 | 5篇 |
2000年 | 1篇 |
1999年 | 9篇 |
1998年 | 16篇 |
1997年 | 17篇 |
1996年 | 16篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1993年 | 7篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 5篇 |
1981年 | 3篇 |
1969年 | 1篇 |
排序方式: 共有200条查询结果,搜索用时 31 毫秒
191.
ATSUSHI IMAMURA KENJI SUGAI SEIJI WATANABE FUMIHIKO HAMADA TAKANOBU KURASHIGE SACHIO TAKASHIMA 《Pediatrics international》1994,36(5):527-530
Although marked atrophy of the tegmentum of the mid-brain is a known computed tomography (CT) and magnetic resonance imaging (MRI) feature in patients with dentato-ruburo-pallido-luysian atrophy (DRPLA), this is the first report of marked high signal intensity of the globus pallidus on proton and T2-weighted MR images in a patient in the early stage of DRPLA of the myoclonus epilepsy type. We suggest that the globus pallidus may be involved in the early stage of DRPLA of this type. Magnetic resonance imaging is considered to be useful for the early detection of involvement of the globus pallidus and in the clinical diagnosis of DRPLA. 相似文献
192.
SHIGEAKI MORIURA MAKOTO KURODA ATSUSHI KIMURA YASUSHI IWATSUKA SHUHEI IKEDA TAKASHI SAKAI AKIHIKO USUI 《Journal of gastroenterology and hepatology》1996,11(6):556-559
A 34 year old man with glycogen storage disease type 1a had two hepatic tumours since 18 years of age. They had continued to grow until he was 24 years old, but showed no further growth since then. He underwent a right hepatic trisegmentectomy with caudate lobectomy under veno-venous bypass. The tumour in the posterior segment showed nodule-within-nodule appearance. Histologically, the inner adenoma with dysplasia, bone marrow metaplasia and lymphocytic infiltration was separated by a fibrous band from the outer adenoma of usual histology. 相似文献
193.
CHIKARA OHYAMA ATSUSHI KYAN MAKOTO SATOH SEIICHI SAITO YOSUKE NISHIMURA YOSHITADA IMAI KATSUHIKO OIKAWA JUN YOKOYAMA KENICHI SUZUKI MUTSUO TAKEUCHI SENJI HOSHI SEIICHI ORIKASA 《International journal of urology》2002,9(3):173-177
BACKGROUND: The incidence and clinical features of bilateral germ cell testicular tumor (GCTT) in the Japanese population are not fully characterized. We examined the incidence, clinical features, management and outcome, sexual status, hormonal environment, implication of androgen replacement, and human leukocyte antigen (HLA) typing of bilateral GCTT. METHODS: We treated nine consecutive patients with bilateral GCTT from 1980 through to 1999, and reviewed their hospital and clinic charts. Testosterone, luteinizing hormone, follicle stimulating hormone, dehydroepiandrosterone, and dehydroepiandrosterone-sulfate were measured in bilateral orchiectomized patients. Human leukocyte antigen typing was assessed with peripheral lymphocyte. RESULTS: The incidence of bilateral GCTT against the total number of patients with GCTT was 9/274 (3.3%). The median age of the first tumor was 29 (range 21-75) years. Three cases were synchronous and the remaining six cases were metachronous. In the case of metachronous tumor, the median interval between first and contralateral tumor was 8 (range 2-25) years. Standard treatment was defined as surveillance policy in stage I, chemotherapy for higher stages of non-seminoma, and radiotherapy for stage II seminoma. Human leukocyte antigen typing was examined for seven cases. Five cases were positive for HLA-A24. The incidence of HLA-A24 in bilateral GCTT was identical to that of the Japanese population. The relapsing incidence of stage I disease with surveillance policy was almost identical to unilateral GCTT. A 74-year-old patient with stage II seminoma died of the disease at 1.3 years. The other eight patients remained well without any evidence of recurrence at a median follow-up period of 78 (range 12-204) months. Four patients with bilateral orchiectomy did not require androgen replacement without easy fatigability. Sexual status was conserved using androgen replacement. CONCLUSIONS: Long-term follow-up, as long as 25 years, is recommended for contralateral relapse. Some patients with bilateral orchiectomy do not require androgen replacement. The significance of HLA-A24 for bilateral testicular tumor is equivocal in the Japanese population. 相似文献
194.
TAKESHI ASANO KENTAROH KUWABARA ATSUSHI TAKAGI TAKAYUKI HATORI HISAMITSU HAMADA TAIYOU IMAI OSAMU FUJINO 《Pediatrics international》2007,49(6):1004-1006
Pancreatitis represents an extremely rare complication of typhoid fever. Herein we report the case of a 4-year-old Bangladeshi girl with acute pancreatitis caused by Salmonella typhi. 相似文献
195.
SHIGEYASU SATO HIDEHARU KANZAKI MASUMI YOSHIDA MAKOTO TOKUSHIGE HUEI-SHENG WANG MASATOSHI KARIYA NORIHIKO OKAMOTO YOSHITAKA KARIYA ATSUSHI UCHIDA SHINPEI KASAKURA TAKAHIDE MORI 《American journal of reproductive immunology (New York, N.Y. : 1989)》1990,24(3):67-72
ABSTRACT: T-lineage cells in human decidua of early pregnancies were tested for surface markers, proliferative response, interleukin-2 (IL-2) production, and natural killer (NK) activity. T-lineage (CD2+) cells that were obtained from decidua by the use of E-rosette formation contained fewer CD3+ mature T cells and CD4+ cells than those from the peripheral blood of the same donors, while no differences were seen in the frequencies of CD8+ cells. P55 molecules of IL-2 receptor (IL-2R/p55, Tac antigen) were hardly detected on fresh decidual T-lineage cells, though approximately 20% were positive for HLA-DR. More than a half of decidual T-lineage cells expressed CD56 molecules on their surface and killed K562 cells, the prototype target of NK cells, while most of them were negative for CD16 and CD57. Upon stimulation with IL-2, decidual T-lineage cells demonstrated dose-dependent proliferative response. In addition, they were induced to produce high amounts of IL-2 by stimulation with mitogens but not with alloantigens. These results suggest that human decidua contains high numbers of CD2+3-CD16+56+ lymphocytes and that this population responds to IL-2, produces IL-2 and mediates NK activity. 相似文献
196.
NORIHIKO OKAMOTO ATSUSHI UCHIDA KENJI TAKAKURA YOSHITAKA KARIYA HIDEHARU KANZAKI LEENA RIITTINEN RIITTA KOISTINEN MARKKU SEPPL TAKAHIDE MORI 《American journal of reproductive immunology (New York, N.Y. : 1989)》1991,26(4):137-142
ABSTRACT: Human decidua of early pregnancy contains considerable numbers of CD3? CD56+ natural killer (NK) cells. In this study, two major protein products of the decidua, placental protein 14 (PP14) and placental protein 12 (PP12), were tested for the ability to regulate human NK cell activity. In vitro overnight exposure to PP14 of blood lymphocytes or purified large granular lymphocytes (LGL) resulted in suppression of cytotoxicity against K562 target cells in a 4-h 51Cr release assay. The NK inhibition was dependent on concentrations of PP14, being detectable at 5 μg/ml and reaching maximum at 50 μg/ml. Manifestation of PP14-induced NK suppression required 18-h contact with NK cells. The suppression of NK activity by PP14 was not abolished by indomethacin. In a target binding assay the number of PP14-treated LGL binding to K562 was comparable to that of untreated ones. By contrast with PP14, PP12 produced no effects on NK cells. These results indicate that PP14 suppresses the function of NK cells, which might be involved in prevention of maternal immune rejection of fetus at the fetomaternal interface. 相似文献
197.
Retrograde Multiple and Multifiber Accessory Pathway Conduction in the Wolff-Parkinson-White Syndrome: 总被引:1,自引:0,他引:1
YOSHITO IESAKA M.D. TEIICHI YAMANE M.D. ATSUSHI TAKAHASHI M.D. MASAHIKO GOYA M.D. SHIGEYUKI KOJIMA M.D. YOHKOH SOEJIMA M.D. YOSHIHIRO OKAMOTO M.D. HIDEOMI FUJIWARA M.D. KAZUTAKA AONUMA M.D. AKIHIKO NOGAMI M.D. MICHIAKI HIROE M.D. FUMIAKI MARUMO M.D. MASAYASU HIRAOKA M.D. 《Journal of cardiovascular electrophysiology》1998,9(2):141-151
Retrograde Multiple Accessory Pathway Precipitating AF. Introduction : The determinants of susceptibility to atrial fibrillation (AF) and the existence of accessory pathway conduction have remained unidentified in the Wolff-Parkinson-White (WPW) syndrome. We tested the hypothesis that excitation inputs into the atrium over a retrograde multiple or multifiber accessory pathway during AV reentrant tachycardia (AVRT) could precipitate initiation of AF.
Methods and Results : Two hundred fifty consecutive patients with WPW syndrome underwent electrophysiologic study and radiofrequency catheter ablation. The patients were classified into two groups according to the study results: 29 with retrograde multiple or multifiber accessory pathway (MP) and 221 with retrograde single accessory pathway (SP). Compared with the SP patients, the MP patients showed a significantly higher incidence of clinical AF (MP vs SP: 19/29 vs 51/221, P < 0.01), induced AF (12/29 vs 32/221, P < 0.01), and initiated AF during ventricular pacing and AVRT (10/12 vs 17/32, P < 0.05). There were no differences between the two groups in incidence of clinical and induced AVRT (24/29 vs 200/221 and 25/29 vs 206/221, respectively), mean cycle length of induced AVRT, or electrophysiologic parameters of the accessory pathway. AF inducibility during AVRT or ventricular pacing was eliminated by partial ablation in 7 of 10 patients with MP. After total ablation, the incidence of induced AF was similar between the two groups (MP vs SP: 1/29 vs 11/221).
Conclusion : The existence of a retrograde multiple or multifiber accessory pathway in patients with WPW syndrome is associated with a higher incidence of clinical and induced AF. Successful ablation of the retrograde multiple or multifiber accessory pathway can eliminate the induction of both AVRT and AF. 相似文献
Methods and Results : Two hundred fifty consecutive patients with WPW syndrome underwent electrophysiologic study and radiofrequency catheter ablation. The patients were classified into two groups according to the study results: 29 with retrograde multiple or multifiber accessory pathway (MP) and 221 with retrograde single accessory pathway (SP). Compared with the SP patients, the MP patients showed a significantly higher incidence of clinical AF (MP vs SP: 19/29 vs 51/221, P < 0.01), induced AF (12/29 vs 32/221, P < 0.01), and initiated AF during ventricular pacing and AVRT (10/12 vs 17/32, P < 0.05). There were no differences between the two groups in incidence of clinical and induced AVRT (24/29 vs 200/221 and 25/29 vs 206/221, respectively), mean cycle length of induced AVRT, or electrophysiologic parameters of the accessory pathway. AF inducibility during AVRT or ventricular pacing was eliminated by partial ablation in 7 of 10 patients with MP. After total ablation, the incidence of induced AF was similar between the two groups (MP vs SP: 1/29 vs 11/221).
Conclusion : The existence of a retrograde multiple or multifiber accessory pathway in patients with WPW syndrome is associated with a higher incidence of clinical and induced AF. Successful ablation of the retrograde multiple or multifiber accessory pathway can eliminate the induction of both AVRT and AF. 相似文献
198.
TADASHI IWAO ATSUSHI TOYONAGA HIROYUKI SHIGEMORI KAZUHIKO OHO MICHIHIRO SUMINO MASAHIRO SATO KYUICHI TANIKAWA 《Journal of gastroenterology and hepatology》1996,11(3):216-222
The effects of vasopressin plus oxygen and vasopressin alone on gastric mucosal perfusion and oxygenation were studied using reflectance spectrophotometry and laser Doppler velocimetry in 23 cirrhotic patients with portal-hypertensive gastropathy. The measurements were performed under basal conditions and after double-blinded administration of placebo (n= 7), vasopressin (0.3 U/min; n= 8) or vasopressin (0.3 U/min) plus nasal oxygen (4 L/min; n= 8). No significant effects on gastric mucosal haemodynamics and oxygenation were observed after placebo. In contrast, vasopressin and vasopressin plus oxygen induced a similar reduction in haemoglobin content (-26 ± 2 and -21 ± 4%, respectively P < 0.01) and laser Doppler signal (-23 ± 2 and -22 ± 2%, respectively, P < 0.01). Although each treatment induced a significant reduction in oxygen saturation (-21 ± 2 and -7 ± 1%, respectively P < 0.01), the effect was less pronounced in patients receiving the combination than in those receiving vasopressin alone (P < 0.01). These data suggest that vasopressin and vasopressin plus oxygen reduce gastric mucosal hyperaemia and that the oxygen supplement partially protects against gastric mucosal hypoxia during vasopressin infusion in cirrhotic patients with portal-hypertensive gastropathy. 相似文献
199.
MICHEL HAÏSSAGUERRE PIERRE JAÏS DIPEN C. SHAH MÉLÈZE HOCINI ATSUSHI TAKAHASHI FIORENZO GAÏTA S. SERGE BAROLD JACQUES CLEMÉNTY 《Pacing and clinical electrophysiology : PACE》1997,20(10):2470-2481
Atrioventricuiar junctional reentrant tachycardia (AVfBT) is the most common form of paroxysmal regular supraventricular tachycardia. In patients with disabling, drug refractory AVJBT, catheter ablation has evolved rapidly from a last-resort treatment in the form of interruption of atrioventricular (AV) conduction to selective modification of AV nodal function as an ideal treatment. This article will focus on the frequently unappreciated electrophysiological activities recordable in man in Kach's triangle during ablation of the so-called slow pathway. 相似文献
200.
Expression of multidrug resistance-related genes does not contribute to risk factors in newly diagnosed childhood acute lymphoblastic leukemia 总被引:4,自引:0,他引:4