全文获取类型
收费全文 | 963篇 |
免费 | 39篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 41篇 |
妇产科学 | 29篇 |
基础医学 | 79篇 |
口腔科学 | 31篇 |
临床医学 | 58篇 |
内科学 | 302篇 |
皮肤病学 | 21篇 |
神经病学 | 73篇 |
特种医学 | 18篇 |
外科学 | 166篇 |
综合类 | 2篇 |
预防医学 | 12篇 |
眼科学 | 1篇 |
药学 | 57篇 |
肿瘤学 | 109篇 |
出版年
2023年 | 10篇 |
2022年 | 3篇 |
2021年 | 15篇 |
2020年 | 8篇 |
2019年 | 18篇 |
2018年 | 27篇 |
2017年 | 19篇 |
2016年 | 26篇 |
2015年 | 27篇 |
2014年 | 35篇 |
2013年 | 51篇 |
2012年 | 67篇 |
2011年 | 71篇 |
2010年 | 36篇 |
2009年 | 33篇 |
2008年 | 61篇 |
2007年 | 57篇 |
2006年 | 48篇 |
2005年 | 53篇 |
2004年 | 56篇 |
2003年 | 44篇 |
2002年 | 34篇 |
2001年 | 27篇 |
2000年 | 22篇 |
1999年 | 10篇 |
1998年 | 9篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 13篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 11篇 |
1991年 | 10篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 13篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1979年 | 3篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1913年 | 1篇 |
1905年 | 1篇 |
1894年 | 1篇 |
排序方式: 共有1005条查询结果,搜索用时 171 毫秒
81.
Jejuno-jejunal invagination due to intestinal melanoma 总被引:1,自引:1,他引:0
Resta G Anania G Messina F de Tullio D Ferrocci G Zanzi F Pellegrini D Stano R Cavallesco G Azzena G Occhionorelli S 《World journal of gastroenterology : WJG》2007,13(2):310-312
Cutaneous melanoma is one of the most studied neoplastic lesions in biology and clinical oncology. It has been well documented that this type of neoplasm presents a high metastatic rate, and is able to involve nearly every tissue. Non-cutaneous melanoma represents an unusual pattern of melanoma, and the small intestine is an uncommon anatomic localization. Herein we report an extremely rare clinical case of a young woman affected by a bleeding jejunal melanoma, whose early clinical presentation was an intestinal invagination. 相似文献
82.
Caso V Paciaroni M Venti M Alberti A Palmerini F Milia P Billeci AM Silvestrelli G Biagini S Agnelli G 《Cerebrovascular diseases (Basel, Switzerland)》2007,24(2-3):215-218
BACKGROUND: Antiplatelet treatment remains the first choice for primary and secondary prevention of vascular diseases; even so, expected benefits may be offset by risk of bleeding, particularly cerebral hemorrhage. The aim of this study was to assess the influence of antiplatelet treatment on clinical outcome at hospital discharge. MATERIALS AND METHODS: Consecutive patients with first-ever stroke due to a primary intraparenchymal hemorrhage were prospectively identified over a 4-year period (2000-2003). Data on hemorrhage location, vascular risk factors, and antiplatelet and anticoagulant treatment were collected. At discharge, outcome was measured using the modified Rankin Scale (disabling stroke > or =3). Patients treated with anticoagulant therapy were excluded from the study. RESULTS: Of 457 consecutive patients with cerebral hemorrhage, 94 (20.5%) had been taking antiplatelet agents. The treated patients (mean age for antiplatelet group 78.9 +/- 9.0 years) were older than the nontreated patients (73.8 +/- 9.4, p = 0.02). In-hospital mortality was 23.4 and 23.1% (p = n.s.) for patients who had been taking antiplatelet agents or no treatment. Poor outcome at discharge was found in 52.1 and 59.7% (p = n.s.), respectively. Univariate analysis showed that age and coma at admission were predictors of disability at discharge, but antiplatelet treatment was not. Additionally, age and coma were shown to be determinants of disability at discharge after multivariate analysis: OR 1.03 per year (95% CI: 1.018-1.049), p < 0.001 and OR 1.68 (95% CI: 1.138-2.503), p = 0.009, respectively. CONCLUSIONS: Hemorrhagic stroke continues to be responsible for a high percentage of disability and death. Furthermore, it was seen here that functional outcome was independent of previous antiplatelet treatment. 相似文献
83.
Eguchi K Boden-Albala B Jin Z Di Tullio MR Rundek T Rodriguez CJ Homma S Sacco RL 《The American journal of cardiology》2007,100(9):1404-1409
It is still controversial whether fasting blood glucose (FBG) is associated with the risk of vascular outcomes among nondiabetic subjects. We sought to determine whether FBG is associated with vascular outcomes and whether this association differs among various racial or ethnic groups. In the Northern Manhattan Study, a total of 2,372 subjects (mean age 68.8 +/- 10.7 years, 36% men) without a history of diabetes mellitus, stroke, or myocardial infarction (MI) were followed for an average of 7.5 years for ischemic stroke, MI, and combined vascular events defined as either ischemic stroke, MI, or vascular death. Cox proportional-hazards models were used to calculate hazard ratios and 95% confidence intervals (CIs) of FBG-associated risk for vascular outcomes after adjusting for age, gender, race/ethnicity, education, body mass index, hypertension, current smoking, previous coronary artery disease, low-density lipoprotein cholesterol, alcohol intake, and physical activity. The incidences of MI, ischemic stroke, and combined vascular events were 5.5, 6.3, and 20.0 per 1,000 person-years, respectively. Each SD increase of FBG (27 mg/dl) was associated with statistically significantly increased risks of combined vascular events (hazard ratio 1.20, 95% CI 1.09 to 1.31) and MI (hazard ratio 1.21, 95% CI 1.02 to 1.44), but the effect was weaker, evident for ischemic stroke (hazard ratio 1.13, 95% CI 0.95 to 1.34). FBG was significantly associated with incident ischemic stroke among African-American subjects (hazard ratio 1.38, 95% CI 1.09 to 1.74) and incident MI among Hispanic subjects (hazard ratio 1.24, 95% CI 0.99 to 1.55). In conclusion, FBG was an independent predictor for vascular outcomes among individuals without history of diabetes from this multiethnic cohort. The effects were more apparent for MI than for ischemic stroke; however, FBG was a strong predictor of ischemic stroke among African-American subjects. 相似文献
84.
Danilo Franco MD Alessandro Santoro MD Giuseppe Di Gioia MD PhD Marco Ferrone MD PhD Stefania Tramonte MD Luigi Salemme MD Angelo Cioppa MD Gregory Popusoi MD Armando Pucciarelli MD Sebastiano Verdoliva MD Michele Franzese MD Simion Marga MD PhD Dimitris Christodoulakis MD Emanuele Barbato MD PhD Tullio Tesorio MD PhD 《Echocardiography (Mount Kisco, N.Y.)》2023,40(8):768-774
Background
Aortic valve stenosis (AS) is the most common valvular heart disease worldwide. When timely intervention is performed, aortic valve replacement can improve patients' quality and duration of life. Load-independent left ventricular (LV) functional assessments, such as myocardial work indices (MWIs) and LV diastolic function parameters, could help clinicians decide on the optimal timing of intervention.Aims
To evaluate the reliability of MWI in AS patients and the changes in MWI and LV diastolic function after transcatheter aortic valve replacement (TAVR).Methods
We enrolled 53 consecutive patients with severe AS undergoing TAVR admitted between March 2021 and November 2021. MWIs and LV diastolic function were assessed before and after TAVR for each patient.Results
All MWIs and LV diastolic function indices improved after TAVR. The degree of MWIs improvement was higher in patients with lower prior-TAVR MWI values, while the more severe the impairment of diastolic function, the greater the post-TAVR benefit.Conclusion
The introduction of myocardial work parameters into the routine assessment of patients with AS could improve our understanding of cardiac performance and aid in identifying the optimal timing for surgical or percutaneous treatment. 相似文献85.
Dual-energy computed tomography for the differentiation of uric acid stones: ex vivo performance evaluation 总被引:1,自引:0,他引:1
Stolzmann P Scheffel H Rentsch K Schertler T Frauenfelder T Leschka S Sulser T Marincek B Alkadhi H 《Urological research》2008,36(3-4):133-138
We assessed the potential of dual-energy computed tomography (CT) for the differentiation between uric acid (UA)-containing and non-UA-containing urinary stones. Forty urinary stones of 16 different compositions in two sizes (< and >/= 5 mm) were examined in an ex vivo model. Thirty stones consisted of pure calcium oxalate (whewellite or wheddellite), calcium phosphate (apatite, brushite, or vaterite), ammonium magnesium phosphate (struvite), UA, ammonium acid urate, ammonium phosphate, sodium hydrogen urate, or cystine, and ten stones were of mixed composition (UA-sodium hydrogen urate, whewellite-urate, wheddellite-urate, whewellite-brushite, or whewellite-brushite-struvite). Scans were performed using dual-source CT in a dual-energy mode with the tubes simultaneously operating at 80 and 140 kV. Two readers analysed the data with respect to stone attenuation at each energy level. The stones were classified as UA- or non-UA-containing using manual attenuation measurements and software analysis results. Sensitivity, specificity, PPV, and NPV were calculated using crystallographic stone analysis as the gold standard. Twenty-six out of 40 stones (65%) contained no UA; 14 stones (35%) contained UA. When compared with UA-containing stones, the differences in attenuation values at 80 and 140 kV were significantly (P < 0.001) higher in stones containing no UA. The software automatically mapped 39/40 stones (98%). Only one (2%) 2 mm UA-stone was missed. The software correctly classified all detected stones as UA- or non-UA-containing. The attenuation values of the missed stone were manually plotted into the analysis sheet which allowed for the correct classification of the stone (containing UA). Therefore, the sensitivity, specificity, PPV, and NPV for the detection of UA-containing stones was 100%. Ex vivo experience indicates that differentiation between UA- and non-UA-containing stones can be accurately performed using dual-source dual-energy CT. 相似文献
86.
A laparoscopic or retroperitoneoscopic access to the adrenal gland is the standard of care for adrenalectomy in most cases.
Although in laparoscopic adrenalectomy the approach is minimally invasive, the procedure is challenging. This is reflected
in the scope of possible complications. The surgeon must consider complications related to the anatomical topography of the
adrenal gland, which typically encompasses the complications known from open surgery and complications related to the minimal
invasive access. In this topic paper we will address the most frequently encountered complications of adrenalectomy: vascular
injuries, injuries of the bowel, pleural tears, and injuries to the liver, spleen and pancreas. Fortunately, these complications
occur rarely. However, many of these complications can have devastating consequences. Therefore, it’s the surgeon’s obligation
to be aware of the possible complications he might encounter during laparoscopic adrenalectomy. This awareness is essential
for their prevention and it helps the laparoscopic surgeon to identify complications intraoperatively. 相似文献
87.
88.
89.
Alberto Tosetto Francesco Rodeghiero Elisabetta Gatto Cesare Manotti Tullio Poli 《American journal of hematology》1995,48(1):34-39
We report a new case of severe bleeding diathesis due to an acquired inhibitor of fibrin crosslinking. The patient, an 80-year-old woman, was admitted to the hospital for a massive subcutaneous hematoma, with severe anemia requiring red cell transfusion; a subsequent retroperitoneal hematoma developed 2 weeks later. Coagulation studies were normal except for a thromboelastographic pattern suggestive of FXIII deficiency. Clot solubility test was abnormal even after 1: 1 mix with normal plasma. Immunochemical studies confirmed the presence of a monoclonal IgG lambda inhibitor directed against FXIII activity (type II FXIII inhibitor). The patient IgG fraction selectively inhibited FXIII transamidating activity but did not inhibit the thrombin-mediated activation of FXIII. The patient was treated with high doses of FXIII concentrate to overcome the inhibitor and immunosuppressive therapy with cyclophosphamide and discharged in good conditions. High doses of commercially available FXIII appear to be a safe and effective method of controlling acute episodes of bleeding in patients with acquired FXIII deficiency. ©1995 Wiley-Liss, Inc. 相似文献
90.
Barbara Camponeschi Sandra Lucarelli Tullio Frediani Maria Barbato Francesea Quintieri 《Pediatric allergy and immunology》1997,8(2):106-109
In this study we investigated the HLA association with cow milk allergy. Thirty-seven Italian children with cow milk allergy and 35 randomly selected age-matched healthy children as control group were included in the study. DNA typing was performed by restriction fragment length polymorphism (RFLP) technique. We show the first statistically significant positive association between the expression of the HLA-DQ7 antigen and cow milk allergy. Several immunological tests (skin prick test, RIA, radioallergosorb-ent test (RAST) and ELISA) were performed to evaluate the humoral immune responses of DQ7 positive and DQ7 negative allergic patients. Our results show that among the DQ7 positive patients the majority presented a high humoral response. Furthermore, the in vitro proliferative response of patients to the †-lactoglobulin antigen was performed to evaluate their cell-mediated immune response. We observed that the number of the nonre-sponders was higher in the DQ7 positive patients when compared to the DQ7 negative patients.
Our data indicate an association of HLA-DQ7 antigen with cow milk pro tein allergy and that the DQ7 positive patients had a prevalence of humoral rather than cellular responses. 相似文献
Our data indicate an association of HLA-DQ7 antigen with cow milk pro tein allergy and that the DQ7 positive patients had a prevalence of humoral rather than cellular responses. 相似文献