全文获取类型
收费全文 | 4888篇 |
免费 | 236篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 99篇 |
儿科学 | 59篇 |
妇产科学 | 44篇 |
基础医学 | 575篇 |
口腔科学 | 155篇 |
临床医学 | 339篇 |
内科学 | 1120篇 |
皮肤病学 | 101篇 |
神经病学 | 369篇 |
特种医学 | 261篇 |
外科学 | 816篇 |
综合类 | 15篇 |
预防医学 | 220篇 |
眼科学 | 131篇 |
药学 | 292篇 |
中国医学 | 7篇 |
肿瘤学 | 550篇 |
出版年
2023年 | 39篇 |
2022年 | 18篇 |
2021年 | 119篇 |
2020年 | 67篇 |
2019年 | 102篇 |
2018年 | 109篇 |
2017年 | 85篇 |
2016年 | 111篇 |
2015年 | 115篇 |
2014年 | 160篇 |
2013年 | 181篇 |
2012年 | 311篇 |
2011年 | 352篇 |
2010年 | 176篇 |
2009年 | 159篇 |
2008年 | 305篇 |
2007年 | 312篇 |
2006年 | 379篇 |
2005年 | 341篇 |
2004年 | 355篇 |
2003年 | 319篇 |
2002年 | 313篇 |
2001年 | 41篇 |
2000年 | 43篇 |
1999年 | 66篇 |
1998年 | 64篇 |
1997年 | 66篇 |
1996年 | 50篇 |
1995年 | 41篇 |
1994年 | 59篇 |
1993年 | 38篇 |
1992年 | 35篇 |
1991年 | 28篇 |
1990年 | 29篇 |
1989年 | 27篇 |
1988年 | 14篇 |
1987年 | 17篇 |
1986年 | 15篇 |
1985年 | 11篇 |
1984年 | 17篇 |
1983年 | 9篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1973年 | 2篇 |
1969年 | 3篇 |
1965年 | 2篇 |
1930年 | 1篇 |
排序方式: 共有5153条查询结果,搜索用时 140 毫秒
21.
Abstract: This case report describes a patient with a rectal ulcer who had an unusual defecation habit. Complete healing was recognized colonoscopically after the patient was instructed to break this habit. A polyp of the ascending colon was detected by a barium enema in a 37-year-old man complaining of anal bleeding. He was admitted to our division to undergo a polypectomy. At the time of the polypectomy, a round ulcer, measuring 1 cm in diameter, was detected on the right wall of the rectum 3 cm from the anal verge. A diagnosis of mucosal prolapse syndrome of the rectum could not be made because the patient did not exhibit the characteristic habit of excessive “straining” mentioned by patients with this syndrome, and no characteristic finding of fibromuscular obliteration was found on histological examination of biopsied specimens taken endoscopically from the lesion. Repeated history taking, however, revealed that the patient had the unusual habit of inserting his finger into his rectum after defecation. He broke this habit following instruction to do so. As a result, on colonoscopic examination 15 month later, the ulcer was found to have become a scar: 相似文献
22.
Hiroaki Nomori Kazunori Iwatani Hironori Kobayashi Atsushi Mori Shouichi Yoshioka 《Annals of thoracic and cardiovascular surgery》2006,12(2):83-88
To reduce or omit a mediastinal lymph node dissection in the patients with clinical stage I non-small cell lung cancer (NSCLC), several authors examined the prevalence of metastatic sites of lymph nodes. Because lymphatic drainage usually heads for the upper mediastinum in upper lobe cancer and for the lower mediastinum in lower lobe cancer, upper and lower mediastinal lymph node dissection could be reduced in lung cancers of lower lobe and upper lobe. By using sentinel node (SN) navigation surgery, it is possible to omit mediastinal lymph node dissection. Radiological findings are also useful to determine reduction of mediastinal lymph node dissection. In clinical stage Ia adenocarcinomas that show ground glass opacity (GGO) findings on computed tomography (CT) or negative for fluorodeoxyglucose accumulation on positron emission tomography (PET), mediastinal lymph node dissection can be omitted, because these types of adenocarcinomas rarely metastasize to the lymph nodes. By using these procedures, mediastinal lymph node dissection can be reduced or omitted with little risk of local recurrence. 相似文献
23.
三氧化二砷诱导慢性髓系白血病细胞G2/M周期停滞及其机理 总被引:3,自引:1,他引:2
目的 研究三氧化二砷对慢性髓系白血病细胞的体外作用特点及其机理。方法 将三氧化二砷与慢性髓性白血病细胞系K562作用后,测定细胞的生长曲线及活性,流式细胞测量术检测细胞凋亡和细胞周期分布的改变;同时,采用RT-PCR方法检测药物作用前后细胞周期相关基因表达的变化。结果 ①三氧化二砷明显抑制K562细胞的生长,其作用呈时间和浓度依赖性;②三氧化二砷诱导K562细胞凋亡的作用较弱,但可明显诱导K562细胞在G2/M期停滞,此效应也呈时间和浓度依赖性;③三氧化二砷作用后,细胞周期抑制基因p57表达明显上调,而细胞周期促进基因cyclinB的表达受到抑制。结论 三氧化二砷能有效抑制慢性髓系白血病细胞的生长,其机理主要为诱导细胞G2/M期周期停滞;该效应与细胞周期相关基因的表达变化有关。 相似文献
24.
25.
Satoshi Tobe Kazunori Yoshida Masahiro Yamaguchi Haruko Nishimura Masahito Kawata 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(7):308-310
Papillary fibroelastoma (PFE) is a rare and benign cardiac tumor typically found on the valvular endocardium. In most cases,
PFE is identified incidentally on echocardiography or during cardiac surgery. The patient was a 73-year-old man who had been
treated for hepatocellular carcinoma for 5 years. On echocardiography, a 2.5-cm diameter mass was detected in the pulmonary
trunk just above the pulmonary valve. Through a transpulmonary arterial approach with cardiopulmonary bypass, the mass identified
on the commissure of the right and posterior pulmonary cusp was surgically excised together with the attached endocardium.
Despite the benign histology of PFE, lethal embolic events such as stroke, myocardial infarction, and pulmonary embolism are
reported in some cases. To prevent such complications, tumor identification and surgical excision are essential. 相似文献
26.
Harukazu Tohyama Kazunori Yasuda Bruce D. Beynnon Per A. Renstrom 《Knee surgery, sports traumatology, arthroscopy》2006,14(4):373-378
The combined effects of bracing, axial compression and inversion rotation on the ankle-subtalar complexes were evaluated. Ex vivo tests under the load-controlled condition were performed on six cadaver ankle specimens using a six degree-of-freedom fixture. Inversion rotation was measured while subjecting the ankle-subtalar complex to a 2.5 N-m inversion moment and a combination of the testing variables (brace type, no brace, 178 N axial compression load, no compression load, 0° and 20° of plantar flexion) for a total of 16 tests per specimen. Three commercially available braces (two semirigid types and one lace up type) were evaluated. An axial compression load significantly decreased ankle-subtalar motion in unbraced ankles for the tested inversion moment. The contribution of bracing to stabilization of the ankle was smaller in the axial loading condition than in the no axial loading condition. The semirigid braces had greater stabilizing effects in response to the inversion moment than the lace up brace. Stabilizing effects of bracing were significantly greater in 20° of plantar flexion than in 0° of plantar flexion. The most common mechanism for an ankle sprain injury is inversion rotation on a weight-bearing ankle. Therefore, we should not overestimate stabilizing effects of bracing from evaluations of bracing without axial compression loading. 相似文献
27.
Shin-ichi Imamura Tatsui Nagado Yuji Toyomitsu Shigeya Tanaka Kazunori Arita 《Brain and nerve》2006,58(2):151-154
We reported a 57-year-old female patient recently suffering from frequent seizures such as motionless staring and oral automatism. Electroencephalograms showed spikes in the right sphenoidal derivation and magnetic resonance images revealed an abnormal region, most likely related with a migration disorder such as a focal cortical dysplasia. She was diagnosed as mesiotemporal lobe epilepsy associated with a migration disorder. Seizure disappeared after medication therapy was done. No previous literature has described such a case, thus this is the first report of an epilepsy associated with migration disorder newly onset in a patient older than 50 years old. 相似文献
28.
Kazunori Yokohata Hiroshi Kimura Gen Naritomi Hiroyuki Konomi Torahiko Takeda Yoshiaki Ogawa Masao Tanaka 《Journal of Hepato-Biliary-Pancreatic Surgery》1994,1(3):236-239
The role of endoscopic retrograde cholangiopancreatography (ERCP) in the preoperative assessment of anomalous pancreaticobiliary
junction was retrospectively evaluated in 74 consecutive patients (19 males and 55 females; aged 0–80 years). Sixty-three
patients had congenital biliary dilatation and 11 did not. Type classification of congenital biliary dilatation was possible
by ERCP alone in 45 patients (71%). The main causes of classification failure were previous bilio-enteric anastomosis and
restriction of postural changes during ERCP due to general anesthesia in pediatric patients. Classification of anomalous junction
was possible in 69 patients (93%). Technical difficulty in ERCP caused classification failure in 5 patients. Neoplastic lesions
were found in 12 patients (16%) and all but 1 were correctly diagnosed by ERCP. We conclude that ERCP plays an important role
in the preoperative diagnosis and type classification of anomalous pancreaticobiliary junction and congenital biliary dilatation. 相似文献
29.
Kazunori Ikebe Kentaro Morii Jumpei Kashiwagi Takashi Nokubi Ronald L Ettinger 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,99(6):704-710
OBJECTIVE: The purpose of this study was to determine the association of dry mouth with oral symptoms and function, such as denture instability, discomfort, soreness in denture-bearing tissue, and dissatisfaction with chewing, tasting, or speaking in removable denture wearers. STUDY DESIGN: The subjects were 493 removable denture wearers with a mean age of 67.3 years. Perception of oral dryness was measured by a questionnaire. A multiple logistic regression analysis was used to determine the effect of the dry mouth on oral symptoms and function after controlling for age and gender. RESULTS: Oral dryness during eating was related to dissatisfaction with chewing (odds ratio, 10.5; P < .001) and speaking (odds ratio, 3.5; P < .05) and overall dissatisfaction (odds ratio, 6.3; P < .01) in complete denture wearers. Feeling of dry mouth was likely to be associated with soreness in denture-bearing tissues in both complete and removable partial denture wearers. CONCLUSIONS: There was a significant association of the perception of dry mouth among a group of denture wearers with oral symptoms and function. 相似文献
30.
Tetsuya Yamamoto Kazunori Yoneda Eisaku Ueta Yukihiro Tatemoto Tokio Osaki 《International journal of clinical oncology / Japan Society of Clinical Oncology》1996,1(3):150-156
Background The antitumor effects of adoptive immunotherapy in combination with chemoradiotherapy were investigated in patients with oral
squamous cell carcinoma.
Methods Inductive chemoradiotherapy with peplomycin, 5-fluorouracil and60Co was given to 56 patients [CRI(−)group]. A local injection of adoptive lymphokine-activated killer (LAK) cells (≈2×108 cells) and small doses of interleukin-2(≈3×105 U) and interferon-gamma (≈2×105U) was given to 40 other patients in combination with the chemoradiotherapy [CRI(+) group].
Results Clinically, CR, PR, and LR were observed in 15 (37.5%), 24 (60.0%), and 1 (2.5%) of the patients in the CRI (+) group, respectively;
and in 14 (25.0%), 38 (67.9%), and 4 of the patients (7.1%) in the CRI (−) group. The histopathological effects were correlated
with the tumor remission rate, with lethal degeneration (grades III and IV), and prominent degeneration (grade IIB) in the
tumor cells noted in 20 (50.0%) and 16 (40.0%) of the CRI(+) patients, respectively; and in 21 (37.5%) and 29 (51.8%) of the
CRI (−) patients. Immunohistochemically, a prominent decrease of proliferating cell nuclear antigenpositive cells with a reciprocal
increase of LeY-positve cells was induced by the chemoradioimmunotherapy. DNA fragmentation was observed in the mutant type p53-negative
tumors in the CRI(+) group.
Conclusion Adoptive immunotherapy with LAK cells and cytokines in combination with chemoradiotherapy induces advantageous anticancer
effects resulting from necrosis and apoptosis. 相似文献