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排序方式: 共有5515条查询结果,搜索用时 169 毫秒
71.
Yong Tao Byunghak Kang Daniel A. Petkovich Yuba R. Bhandari Julie In Genevieve Stein-OBrien Xiangqian Kong Wenbing Xie Nicholas Zachos Shinji Maegawa Himani Vaidya Stephen Brown Ray-Whay Chiu Yen Xiaojian Shao Jai Thakor Zhihao Lu Yi Cai Yuezheng Zhang Hariharan Easwaran 《Cancer cell》2019,35(2):315-328.e6
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Manjulata Kumawat Tarun Kumar Sharma Ishwar Singh Neelima Singh Sanjeev Kumar Singh Veena Singh Ghalaut Vijay Shankar Satish Kumar Vardey 《Disease markers》2012,33(6):303-308
Background: Ageing is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. The study aims to find out the status of lipid profile, antioxidant enzymes, malondialdehyde in geriatric population.
Patients/methods: The study was conducted on 150 subjects (75 healthy control between the ages of 20–30 years and 75 elderly subjects between ages of 50–70 years as cases). The following parameters were analyzed using the standard reference methods: lipid profile, reduced glutathione, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase and malondialdehyde.
Results: The present study was conducted to estimate the oxidative stress parameters in geriatric population. Highly significant increase in total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), malondialdehyde, catalase and decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase was observed in geriatrics when compared with their younger counterparts.
Conclusion: This study concluded that there is enhanced oxidative stress and decreased antioxidant defence in geriatrics as compared to younger subjects which could play an important role in ageing. Dyslipidemia has become one of the important risk factors for the increasing prevalence of cardiovascular diseases. There is lack of awareness on the relationship between blood lipids and the risk of cardiovascular diseases in geriatric population. The strategy of early prevention should be adopted against dyslipidemia. 相似文献
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Multiple sclerosis is commonly associated with bladder dysfunction, which is frequently reported to be the worst aspect of
the disease. Patients may experience bothersome bladder symptoms early in the course, and this should be explored. If necessary,
a formal evaluation of the lower urinary tract should be offered. The type of bladder dysfunction may also change with time,
which highlights the need for continual follow-up assessments. Anticipated problems are incomplete bladder emptying and disorders
with urine storage, which may occur simultaneously. This may lead to symptoms of overactive bladder and recurrent urinary
tract infections. Conservative measures for management should be used initially while other sinister pathology is excluded.
Newer treatments such as botulinum toxin A and neural stimulation techniques are replacing more invasive surgical procedures.
Treatment approaches have been described and should be offered by teams who are familiar with patients having uro-neurological
complaints. 相似文献
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