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101.
CHANDANA MENDIS GIUSEPPE DEL GIUDICE† ASOKA C. GAMAGE-MENDIS CHANTAL TOUGNE† ANTONELLO PESSI‡ SUDATH WEERASINGHE RICHARD CARTER§ KAMINI N. MENDIS 《Parasite immunology》1992,14(1):75-86
Antibodies to two peptides DDAAD and (NANP)40 representing the repetitive sequence of circumsporozoite antigens (CS protein) of P. vivax and P. falciparum respectively were measured in a cohort of 149 and 107 individuals respectively at four, 6 monthly blood surveys performed on residents of Kataragama, a P. vivax malaria endemic region in southern Sri Lanka. The prevalence of antibodies to the CS protein of both species was relatively low being less than 20% to either peptide in the population as a whole, this being consistent with the low entomological inoculation rates in the area. A marked age related prevalence pattern was evident, with the prevalence of antibodies increasing with age to reach between 25 to 30% in the 25-50 year age group in both P. vivax and P. falciparum. The population had had a life long exposure to P. vivax malaria but not to P. falciparum, an epidemic of which occurred in this region a few months prior to the beginning of this study. Nevertheless, the age-related prevalence of these antibodies was identical with respect to the two species. This suggests that the age-related prevalence pattern reflected differences in inoculation rates between the age groups due to differences in exposure to inoculation rather than an age acquired response resulting from a cumulative experience over several years. An analysis of antibody prevalence in individuals showed first, that sporozoite inoculations must have been clustered rather than homogeneously distributed in the population and secondly, that sero-conversion did not correlate with malaria infections in these individuals. 相似文献
102.
LORENZA MAGLIANO MARIA GRAZIA D'ANGELO GIUSEPPE VITA MARIKA PANE ADELE D'AMICO UMBERTO BALOTTIN CORRADO ANGELINI ROBERTA BATTINI LUISA POLITANO Telethon GUP Working Group 《Acta myologica》2014,33(3):136-143
This study explored the burden in parents and healthy siblings of 4-17 year-old patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies, and whether the burden varied according to clinical aspects and social resources.Data on socio-demographic characteristics, patient''s clinical history, parent and healthy children burden, and on parent''s social resources were collected using self-reported questionnaires administered to 336 parents of patients with DMD (246) and BMD (90).Parents of patients with DMD reported higher burden than those of patients with BMD, especially concerning feeling of loss (84.3% DMD vs. 57.4% BMD), stigma (44.2% DMD vs. 5.5% BMD) and neglect of hobbies (69.0% DMD vs. 32.5% BMD). Despite the burden, 66% DMD and 62.4% BMD parents stated the caregiving experience had a positive impact on their lives. A minority of parents believed MD has a negative influence on the psychological well-being (31.0% DMD vs. 12.8% BMD), and social life of unaffected children (25.7% vs. 18.4%).In the DMD group, burden correlated with duration of illness and parent age, and burden was higher among parents with lower social contacts and support in emergencies. In DMD, difficulties among healthy children were reported as higher by parents who were older, had higher burden and lower social contacts. In both groups, burden increased in relation to patient disability.These findings underline that the psychological support to be provided to parents of patients with MD, should take into account clinical features of the disease.Key words: Duchenne muscular dystrophy, Becker muscular dystrophy, parents, healthy siblings, burden, social network 相似文献
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104.
GIANFRANCO PARATI MARCO DI RIENZO STEFANO OMBONP LUISA ULIAN GIUSEPPE MANCIA 《Journal of sleep research》1995,4(S1):21-29
SUMMARY This paper describes several different methods for the analysis of blood pressure and heart rate variability over the 24 hours, both in the time and in the frequency domain. The mechanisms possibly involved in the genesis of the variations in blood pressure and heart rate which occur over a 24-hour period are also discussed. Finally, new approaches to the dynamic evaluation of the sensitivity of baroreflex control of heart rate and of its changes over the 24 hours in daily life conditions, based on computer analysis of the interaction between fluctuations in blood pressure and heart rate, are described. Data obtained by applying these methods in different clinical conditions (normotensive vs. hypertensive subjects, young vs. elderly individuals and pure autonomic failure patients) are presented. 相似文献
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108.
CARLO LA VECCHIA SILVIA FRANCESCHI ADRIANO DECARLI GIUSEPPE GALLUS FABIO PARAZZINI ENZO MERLO 《BJOG : an international journal of obstetrics and gynaecology》1984,91(11):1149-1155
Summary. Between 1970 and 1979, 103 women below 35 years of age with invasive cervical cancer were treated at the First Obstetrics and Gynaecology Clinic of the University of Milan. Nine patients were pregnant or less than 3 months postpartum. Estimated 10–year disease–free survival, determined by the life–table method, was 100% in stage IA (37 patients), 79% in stage IB (45 patients), 67% in stage 11 (15 patients), 0% in stages III (5 patients) and IV (1 patient). Prognosis was also strongly associated with lymph–node involvement, 10–year actuarial survival decreasing from 93% in lymph–node–negative to 44% in lymph–node– positive patients ( P 相似文献
109.
S. SALARDI E. CACCIARI M. G. PASCUCCI E. GIAMBIASI M. TACCONI R. TAZZARI A. CICOGNANI F. BORIANI R. PUGLIOLI W. MANTOVANI S. DONATI 《Acta paediatrica (Oslo, Norway : 1992)》1990,79(4):437-443
ABSTRACT. Urinary albumin excretion (UAE) was determined by radioimmunoassay in two 24 h urine collections from 125 diabetic children and adolescents and from 71 normal children matched for age and sex. Thirteen patients (10.4%) aged > 12 years had microalbuminuria, i. e. log transformed UAE levels above the upper normal range (24.5 mg/24 h). UAE values were positively correlated with age, GH secretion, but not with duration of disease, glycosylated hemoglobin, renal size or N-acetyl-beta-glucosaminidase excretion. Diabetic normoalbuminuric children aged 10 years and older had significantly higher UAE than controls and than younger diabetic patients matched for duration of disease. HLA DR3/DR4 heterozygosity frequency was significantly higher (p<0.01) in the microalbuminurine group than in the normoalbuminuric. All microalbuminuric subjects (n=8) with short duration of disease (3.92 ± 3.43 yr) developed diabetes at puberty. In conclusion, our cross-sectional study suggests: if a number of factors are combined, i. e. HLA DR3/DR4 heterozygosity, onset of disease at puberty and higher GH values, the probability of developing abnormal levels of UAE will increase. 相似文献
110.