全文获取类型
收费全文 | 12634篇 |
免费 | 744篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 590篇 |
妇产科学 | 262篇 |
基础医学 | 1752篇 |
口腔科学 | 168篇 |
临床医学 | 981篇 |
内科学 | 2664篇 |
皮肤病学 | 269篇 |
神经病学 | 1325篇 |
特种医学 | 477篇 |
外国民族医学 | 4篇 |
外科学 | 2040篇 |
综合类 | 151篇 |
一般理论 | 3篇 |
预防医学 | 792篇 |
眼科学 | 160篇 |
药学 | 668篇 |
中国医学 | 12篇 |
肿瘤学 | 970篇 |
出版年
2021年 | 186篇 |
2020年 | 102篇 |
2019年 | 153篇 |
2018年 | 196篇 |
2017年 | 152篇 |
2016年 | 155篇 |
2015年 | 193篇 |
2014年 | 253篇 |
2013年 | 325篇 |
2012年 | 561篇 |
2011年 | 611篇 |
2010年 | 363篇 |
2009年 | 330篇 |
2008年 | 514篇 |
2007年 | 519篇 |
2006年 | 545篇 |
2005年 | 622篇 |
2004年 | 489篇 |
2003年 | 470篇 |
2002年 | 489篇 |
2001年 | 425篇 |
2000年 | 470篇 |
1999年 | 372篇 |
1998年 | 178篇 |
1997年 | 148篇 |
1996年 | 155篇 |
1995年 | 119篇 |
1994年 | 127篇 |
1993年 | 110篇 |
1992年 | 288篇 |
1991年 | 261篇 |
1990年 | 252篇 |
1989年 | 280篇 |
1988年 | 247篇 |
1987年 | 246篇 |
1986年 | 215篇 |
1985年 | 224篇 |
1984年 | 187篇 |
1983年 | 157篇 |
1982年 | 105篇 |
1981年 | 103篇 |
1980年 | 67篇 |
1979年 | 153篇 |
1978年 | 108篇 |
1977年 | 72篇 |
1976年 | 78篇 |
1975年 | 73篇 |
1974年 | 105篇 |
1973年 | 95篇 |
1972年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
101.
F A Pirzada J W McDowell E M Cohen V K Saini R L Berger 《The New England journal of medicine》1974,291(17):892-895
102.
A. M. Hirschl M. M. Hirschl J. Berger M. L. Rotter 《European journal of clinical microbiology & infectious diseases》1991,10(11):971-974
The value of a commercially available latex test (Pyloriset) for the diagnosis ofHelicobacter pylori infection by demonstration of specific antibodies was compared with that of direct diagnostic methods such as culture, biopsy-urease test and microscopy of fuchsin-stained smears. The sera were from 136 patients who prior to this study either had or had not been treated forHelicobacter pylori-infection simultaneously with amoxicillin (3 × 750 mg/day) and metronidazole (3 × 500 mg/day) for 12 days. On average, the sensitivity of the test was 90 %. The specificity with sera from untreated patients was 75.9 %; with sera from treated patients specificity was 22.2 %, 28 % and 20 % 1, 3 and 6 months respectively after start of treatment. Only as late as one year after the onset of chemotherapy did the specificity return to 67 %. Because of its low specificity this test does not offer any advantage over other tests in the detection ofHelicobacter pylori-infection or in monitoring the chemotherapeutic success. 相似文献
103.
Marie -Christine Broillet Anouk Berger Jean -Daniel Horisberger 《Pflügers Archiv : European journal of physiology》1993,424(1):91-93
Summary Aldosterone increases the basolateral conductance in target epithelia. The basolateral membrane of tight epithelia contains two different types of K+ conductances (GK), a resting and a volume-activated GK. We have studied the early effects (at 4 hours) of 500 nmol/l aldosterone on the basolateral membrane Gk of A6 cells (a Xenopus laevis kidney cell line), after the permeabilization of the apical membrane with amphotericin B. In the presence of a 97 to 3 mmol/l apical to basolateral K+ gradient, the resting, inward rectifying GK was similar in control and aldosterone treated cells. In contrast, aldosterone induced a 2-fold increase of the volume-activated quinidine sensitive GK. 相似文献
104.
Bersinger NA; Brandenberger A; Berger E; Baumann CK; Birkhauser MH 《Human reproduction (Oxford, England)》1998,13(7):1962-1967
We have previously observed the repeated presence of low but detectable
amounts of the trophoblast marker pregnancy-specific beta1-glycoprotein
(SP1) in the serum of some women undergoing in-vitro fertilization (IVF)
treatment around the time of oocyte retrieval. The occurrence of these
signals seemed to be restricted to a defined group of patients which also
showed a lower pregnancy success rate in a preliminary study. To test our
hypothesis we have analysed 173 consecutive cycles leading to an embryo
transfer. Fifty-four cycles (31%) had a serum SP1 level of at least 0.1
ng/ml between days embryo transfer -5 and embryo transfer (group A). Five
pregnancies were obtained in this group (pregnancy rate = 9.3%), while in
group B, defined by the absence of detectable SP1 before embryo transfer
(119 cycles), 36 ongoing pregnancies were achieved (30.3%). Ten of the 41
pregnancies were achieved in 33 first-time non-pregnant patients undergoing
further attempts during the study period. Again the pregnancy rate was
higher in the first-time group B women (9/23 versus 1/10 for group A).
Patients tended to remain in their groups A or B, the latter being
associated with a better immediate as well as subsequent chance for
pregnancy. Group A cycles had a significantly lower endometrial thickness
two days before oocyte retrieval than group B (P = 0.0011). We postulate
that the presence of an unknown, maternal and progesterone- or follicle
stimulating hormone-independent factor in some patients could stimulate
tonic ectopic SP1 synthesis and at the same time negatively influence
endometrial development.
相似文献
105.
Cutaneous manifestations of opportunistic infections in patients infected with human immunodeficiency virus. 总被引:2,自引:1,他引:2 下载免费PDF全文
Bacillary angiomatosis (BA) presents most commonly as a cutaneous disease and is caused by two organisms. Bartonella (Rochalimaea) henselae and Bartonella (Rochalimaea) quintana. Biopsy confirmation of cutaneous BA is essential because lesions can mimic nodular Kaposi's sarcoma in appearance. Although the vast majority of human immunodeficiency virus (HIV)-infected patients with BA have CD4 lymphocyte counts of less than 100 cells per mm3, the disease responds well to antimicrobial therapy. Staphylococcus aureus is the most common bacterial skin pathogen affecting HIV-infected patients. The prevalence of skin disease due to S. aureus may be explained by high nasal carriage rates for the organism ( > or = 50%) and altered immune function in conjunction with an impaired cutaneous barrier. Herpes simplex virus causes mucocutaneous disease early in the course HIV infection and ulcerative lesions at any site in advanced HIV infection. Herpes zoster is common early in the course of HIV infection; recurrent and disseminated herpes zoster infections are characteristic of patients with advanced HIV disease. Acyclovir resistance is usually seen in patients with large, untreated, ulcerative lesions of herpes simplex virus and in patients with chronic, verrucous lesions of varicella-zoster virus. Cutaneous cryptococcosis, histoplasmosis, and coccidiomycosis are markers of disseminated disease and require biopsy confirmation. Scabies is easily diagnosed but may be atypical in presentation and difficult to eradicate in advanced HIV disease. 相似文献
106.
Schachinger H Hegar K Hermanns N Straumann M Keller U Fehm-Wolfsdorf G Berger W Cox D 《Journal of behavioral medicine》2005,28(6):587-594
Although both diabetes and the efficacy of medical management are international issues, psycho-educational interventions might
be culturally bound. Blood Glucose Awareness Training (BGAT) is a psycho-educational program for patients with type 1 diabetes
mellitus. It is focused on improving recognition and management of extreme blood glucose levels, and is the best documented
American psycho-educational program for this purpose. A randomized controlled clinical trial of BGAT's long-term benefits
in a non-American setting has been lacking. One hundred and eleven adults with type 1 diabetes mellitus from Switzerland and
Germany participated. After a 6 months baseline assessment, subjects were randomly assigned to receive either 2 months of
BGAT (n = 56) or a physician-guided self-help control intervention (n = 55). BGAT improved recognition of low (p = 0.008), high (p = .03), and overall blood glucose (p = 0.001), and reduced frequency of severe hypoglycemia (p = 0.04), without compromising metabolic control. BGAT reduced both the external locus of control (p < 0.02) and fear of hypoglycemia (p < 0.02). BGAT was efficacious in reducing adverse clinical events and achieving clinically desirable goals in a European,
as well as American setting. 相似文献
107.
108.
Seroprevalence of Ehrlichia canis and of Canine Granulocytic Ehrlichia Infection in Dogs in Switzerland 总被引:1,自引:0,他引:1 下载免费PDF全文
Nicola Pusterla Jeannine Berger Pusterla Peter Deplazes Celestine Wolfensberger Werner Müller Angelika Hrauf Claudia Reusch Hans Lutz 《Journal of clinical microbiology》1998,36(12):3460-3462
Serum samples from 996 dogs in Switzerland were examined for antibodies to Ehrlichia canis and to the agent causing canine granulocytic ehrlichiosis (CGE). Ehrlichiosis, borreliosis, and systemic illness not associated with ticks were suspected in 75, 122, and 157 of these dogs, respectively. The remainder of the serum samples were obtained from clinically healthy dogs which resided north (n = 235) or south (n = 407) of the Alps. The serum samples were tested by an indirect immunofluorescence technique for antibodies to the two agents incriminated, E. canis and Ehrlichia phagocytophila, a surrogate marker of the agent of CGE. Twenty-two of 996 (2.2%) serum samples had antibodies to E. canis and were distributed as follows: 20 of 75 (26.7%) samples from dogs suspected of having ehrlichiosis, 1 of 122 (0.8%) from dogs suspected of having borreliosis, and 1 of 407 (0.2%) from healthy dogs which resided south of the Alps. Of the 75 (7.5%) serum samples that had antibodies to E. phagocytophila, significantly more samples were from ill dogs than from healthy dogs. Among the sera from healthy dogs, antibodies to E. phagocytophila were significantly more prevalent in the north. Because seropositive dogs had a history of travel outside Switzerland and because Rhipicephalus sanguineus is found exclusively south of the Alps, it was presumed that, in contrast to the agent of CGE, E. canis is not indigenous to Switzerland. 相似文献
109.
Swiedler SJ Beck M Bajbouj M Giugliani R Schwartz I Harmatz P Wraith JE Roberts J Ketteridge D Hopwood JJ Guffon N Sá Miranda MC Teles EL Berger KI Piscia-Nichols C 《American journal of medical genetics. Part A》2005,(2):144-150
A cross-sectional survey in individuals affected with the lysosomal storage disease Mucopolysaccharidosis VI (MPS VI) was conducted to establish demographics, urinary glycosaminoglycan (GAG) levels, and clinical progression of the disease. The survey evaluated 121 bona fide MPS VI-affected individuals over the age of 4 years from 15 countries across the Americas, Europe, and Australasia representing greater than 10% of the estimated world prevalence of the disease. A medical history, complete physical exam, urinary GAG determination, and assessment of several clinical measures related to physical endurance, pulmonary function, joint range of motion, strength, and quality of life were completed for each participant. Although a wide variation in clinical presentation was observed, several general findings were obtained reflecting progression of the disease. Impaired physical endurance, as measured by the distance achieved in a 6-min walk, could be demonstrated across all age groups of MPS VI-affected individuals. High urinary GAG values (>200 mug/mg creatinine) were associated with an accelerated clinical course comprised of age-adjusted short stature and low body weight, impaired endurance, compromised pulmonary function, and reduced joint range of motion. An unexpected result was the predominance of urinary GAG values <100 mug/mg creatinine for those participants over the age of 20 years. Pending the collection of longitudinal data, these results suggest that urinary GAG levels predict clinical morbidity, and longer-term survival is associated with urinary GAG levels below a threshold of 100 mug/mg creatinine. 相似文献
110.
Thies A Schachner M Berger J Moll I Schulze HJ Brunner G Schumacher U 《The Journal of pathology》2004,203(4):933-939
Aberrant glycosylation is a common feature of metastatic sub-clones of malignant tumours and in uveal melanoma in particular, the HNK-1 glycotope has been positively correlated with poor prognosis. So far, no such correlation has been investigated in cutaneous melanoma. In order to do so, HNK-1 expression was evaluated immunohistochemically in 100 primary cutaneous melanomas and correlated with metastasis after up to 10-years' follow-up. Furthermore, HNK-1 expression was analysed in metastatic deposits (19 distant cutaneous metastases and six sentinel lymph node metastases), as well as in benign nevi. Kaplan-Meier analysis revealed a positive association between HNK-1 expression and metastasis (p < 0.005) and multivariate Cox regression analysis adjusted for the standard prognostic markers ulceration and vertical tumour thickness confirmed HNK-1 expression as an independent prognostic marker. HNK-1 expression was preserved in 42% of the distant cutaneous metastases, but metastatic cells in lymph nodes were devoid of HNK-1 immunoreactivity. None of the benign pigmented lesions exhibited HNK-1 immunoreactivity. Expression of the HNK-1 glycotope in cutaneous malignant melanoma is an independent prognostic marker of metastasis. Differential HNK-1 expression at the metastatic sites implies that its expression is modulated by the surrounding environment. As HNK-1 is also transiently expressed during migration of melanocyte precursor cells derived from the neural crest, recapitulation of this transient expression might occur during metastatic spread of cutaneous malignant melanoma. 相似文献