全文获取类型
收费全文 | 48060篇 |
免费 | 3231篇 |
国内免费 | 258篇 |
专业分类
耳鼻咽喉 | 420篇 |
儿科学 | 1386篇 |
妇产科学 | 1274篇 |
基础医学 | 6386篇 |
口腔科学 | 967篇 |
临床医学 | 4909篇 |
内科学 | 10231篇 |
皮肤病学 | 913篇 |
神经病学 | 5112篇 |
特种医学 | 1602篇 |
外科学 | 6467篇 |
综合类 | 235篇 |
一般理论 | 22篇 |
预防医学 | 3678篇 |
眼科学 | 807篇 |
药学 | 3137篇 |
1篇 | |
中国医学 | 87篇 |
肿瘤学 | 3915篇 |
出版年
2024年 | 54篇 |
2023年 | 481篇 |
2022年 | 494篇 |
2021年 | 1838篇 |
2020年 | 1087篇 |
2019年 | 1522篇 |
2018年 | 1735篇 |
2017年 | 1219篇 |
2016年 | 1380篇 |
2015年 | 1579篇 |
2014年 | 2193篇 |
2013年 | 2767篇 |
2012年 | 4113篇 |
2011年 | 4104篇 |
2010年 | 2073篇 |
2009年 | 1921篇 |
2008年 | 3261篇 |
2007年 | 3163篇 |
2006年 | 2855篇 |
2005年 | 2830篇 |
2004年 | 2373篇 |
2003年 | 2144篇 |
2002年 | 1930篇 |
2001年 | 349篇 |
2000年 | 302篇 |
1999年 | 372篇 |
1998年 | 358篇 |
1997年 | 252篇 |
1996年 | 233篇 |
1995年 | 220篇 |
1994年 | 185篇 |
1993年 | 151篇 |
1992年 | 196篇 |
1991年 | 177篇 |
1990年 | 149篇 |
1989年 | 129篇 |
1988年 | 114篇 |
1987年 | 124篇 |
1986年 | 119篇 |
1985年 | 121篇 |
1984年 | 81篇 |
1983年 | 57篇 |
1982年 | 64篇 |
1981年 | 50篇 |
1980年 | 45篇 |
1979年 | 72篇 |
1978年 | 46篇 |
1976年 | 47篇 |
1974年 | 47篇 |
1973年 | 38篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
91.
92.
Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. 总被引:4,自引:1,他引:3 下载免费PDF全文
93.
Self-expanding mesh stent for endoscopic palliation of rectal obstructing tumors: a preliminary report 总被引:2,自引:0,他引:2
Summary The endoscopic insertion of self-expanding mesh stents in four patients affected by obstructing rectal malignant tumors is reported. The preliminary experience shows that, in the short term, normal defecation was achieved, with no complications. Longer follow-up is necessary to evaluate the duration and the quality of the palliative effect. 相似文献
94.
Andrea Nardini Carlo Piccardi Rodolfo Soncini-Sessa 《Optimal control applications & methods.》1994,15(1):1-12
A suboptimal controller for a class of discrete-time systems is presented. The controller is derived by first solving ‘off-line’ a simplified optimal control problem obtained by neglecting part of the system state and by considering a larger time step, then by solving ‘on-line’ at each time step an optimization problem based on the results of the previously solved ‘off-line’ problem. A simple numerical example is presented to illustrate the control scheme. 相似文献
95.
Enza-Maria Valente Anjum Misbahuddin Francesco Brancati Mark R Placzek Barbara Garavaglia Sergio Salvi Andrea Nemeth Charles Shaw-Smith Nardo Nardocci Anna-Rita Bentivoglio Alfredo Berardelli Roberto Eleopra Bruno Dallapiccola Thomas T Warner 《Movement disorders》2003,18(9):1047-1051
The epsilon-sarcoglycan gene (SGCE) on human chromosome 7q21 has been reported to be a major locus for inherited myoclonus-dystonia. Linkage to the SGCE locus has been detected in the majority of families tested, and mutations in the coding region have been found recently in families with autosomal dominant myoclonus-dystonia. To evaluate the relevance of SGCE in myoclonus-dystonia, we sequenced the entire coding region of the epsilon-sarcoglycan gene in 16 patients with either sporadic or familial myoclonus-dystonia. No mutations were found. This study suggests that epsilon-sarcoglycan does not play an important role in sporadic myoclonus-dystonia and supports genetic heterogeneity in familial cases. 相似文献
96.
An accidental overdose of colchicine by nasal insufflation occurred when the colchicine was mistaken for methamphetamine. Colchicine insufflation is not believed to be a common practice among drug abusers; however, its physical appearance was similar enough to methamphetamine for it to be mistaken for that drug of abuse. In this case a 29-year-old White man presented to the emergency room 3 days after he 'snorted' approximately 200mg of colchicine powder. The colchicine was used as a 'root stimulator' in gardening by the patient's brother and stored in the same cabinet as the methamphetamine. Within 24 hours of exposure the patient began experiencing gastrointestinal distress and myalgia, which eventually prompted him to seek medical attention. The clinical course included hypocalcaemia (69 mg/L--day 5), hypophosphataemia (10 mg/L--day 5) and thrombocytopenia (19 X 10(3)/mm3 - day 8), all of which are consistent with colchicine toxicity. The patient improved with supportive care and electrolyte replacement, and was discharged after an 8-day hospitalisation. 相似文献
97.
Immunoglobulin Gene Rearrangement in Plasma Cell Dyscrasias: Detection of Small Clonal Cell Populations in Peripheral Blood and Bone Marrow 总被引:1,自引:0,他引:1
Falko Fend Katharina Weyrer Johannes Drach Andrea Schwaiger Florian Umlauft Kurt Grü newald 《Leukemia & lymphoma》1993,10(3):223-229
The bone marrow (BM) and peripheral blood (PB) samples of 71 patients with plasma cell dyscrasias were analysed by the Southern blot technique for the presence of clonal immunoglobulin (Ig) gene rearrangements. 53% of BM samples examined were archival material such as air dried BM slides or frozen trephine biopsies. The results were related to bone marrow plasmacytosis as determined by cytology and flow cytometry, and other clinical parameters. Clonal Ig gene rearrangements were found in BM samples of 45 (83%) of 54 MM patients and in 3 of 6 patients with monoclonal gammopathy of unknown significance (MGUS). Clonal cell populations in the PB were detected in 11 (30%) of 37 examined MM patients, but in none of the patients with MGUS or solitary plasmacytoma of bone. PB involvement was associated with progressive disease. Circulating monoclonal cells were significantly associated with higher M-protein levels (p 0.05). Thus, circulating clonal precursor cells are encountered more frequently in active MM. 相似文献
98.
Andrea von Berg Renate Engelstätter Predrag Minic Miodrag Sréckovic Maria Luz Garcia Garcia Tadeusz Lato Jan H. Vermeulen Stefan Leichtl Stefan Hellbardt Thomas D. Bethke 《Pediatric allergy and immunology》2007,18(5):391-400
Ciclesonide is an onsite-activated inhaled corticosteroid (ICS) for the treatment of asthma. This study compared the efficacy, safety and effect on quality of life (QOL) of ciclesonide 160 microg (ex-actuator; nominal dose 200 microg) vs. budesonide 400 microg (nominal dose) in children with asthma. Six hundred and twenty-one children (aged 6-11 yr) with asthma were randomized to receive ciclesonide 160 microg (ex-actuator) once daily (via hydrofluoroalkane metered-dose inhaler and AeroChamber Plus spacer) or budesonide 400 microg once daily (via Turbohaler) both given in the evening for 12 wk. The primary efficacy end-point was change in forced expiratory volume in 1 s (FEV1). Additional measurements included change in daily peak expiratory flow (PEF), change in asthma symptom score sum, change in use of rescue medication, paediatric and caregiver asthma QOL questionnaire [PAQLQ(S) and PACQLQ, respectively] scores, change in body height assessed by stadiometry, change in 24-h urinary cortisol adjusted for creatinine and adverse events. Both ciclesonide and budesonide increased FEV1, morning PEF and PAQLQ(S) and PACQLQ scores, and improved asthma symptom score sums and the need for rescue medication after 12 wk vs. baseline. The non-inferiority of ciclesonide vs. budesonide was demonstrated for the change in FEV1 (95% confidence interval: -75, 10 ml, p = 0.0009, one-sided non-inferiority, per-protocol). In addition, ciclesonide and budesonide showed similar efficacy in improving asthma symptoms, morning PEF, use of rescue medication and QOL. Ciclesonide was superior to budesonide with regard to increases in body height (p = 0.003, two-sided). The effect on the hypothalamic-pituitary-adrenal axis was significantly different in favor of ciclesonide treatment (p < 0.001, one-sided). Both ciclesonide and budesonide were well tolerated. Ciclesonide 160 microg once daily and budesonide 400 microg once daily were effective in children with asthma. In addition, in children treated with ciclesonide there was significantly less reduction in body height and suppression of 24-h urinary cortisol excretion compared with children treated with budesonide after 12 wk. 相似文献
99.
Thomas Teltzrow Franz-Josef Kramer Andrea Schulze Carola Baethge Peter Brachvogel 《Journal of cranio-maxillo-facial surgery》2005,33(5):307-313
INTRODUCTION: The aim of this study was to review complications in a series of 1264 consecutive patients who were operated in a single centre during a 20-year-period. MATERIAL AND METHODS: Complications were documented, their incidences calculated and compared with data from the literature. RESULTS: In 35 patients (2.8%) infection developed requiring extraoral incision and drainage; in 27 patients (2.1%) the inferior alveolar nerve was inadvertently cut; 18 patients (1.4%) had to undergo re-operation due to bending or fracture of osteosynthesis material; 15 patients (1.2%) suffered from bleeding complications; in 12 patients (0.9%) an unfavourable split occurred. In 8 patients (0.6%) foreign bodies were left in situ; in 7 patients a partial weakness of the facial nerve occurred, which was permanent in 1 patient. Six patients (0.5%) with a significantly higher age than average (mean: 33.6 years in comparison with 23.1 years) developed non-union at the site of osteotomy, and the mandible had to be bone grafted. Two patients (0.2%) developed osteomyelitis, and in one patient airway problems led to a need for tracheostomy (0.1%). CONCLUSION: Although some of these complications of bilateral sagittal split with osteotomy carry severe limitations in health related quality of life, it remains an overall safe procedure, demanding, however, comprehensive informed consent. Good knowledge of technical reasons for these complications should help to reduce their incidence. 相似文献
100.