板层巩膜下双咬切术治疗急性闭角型青光眼发作后持续高眼压

目的：评价板层巩膜下双咬切术治疗急性闭角型青光眼发作后持续高眼压状态的疗法。方法：作板层巩膜下床内后切口缓放房水，联合后巩膜咬切及小梁切除术，治疗25例25眼。结果：术后1周平均眼压18mmHg，术后3个月平均眼压17mmHg。全部病例随访3个月无浅前房低眼压现象。结论：板层巩膜下双咬切术治疗急性闭角型青光眼发作后持续高眼压，降眼压效果好，并发症少，治疗效果理想。     

启东肝癌防控策略的研究及现场干预的效果

启东肝癌防治现场在实践中确立了肝癌防控策略,并针对主要病因采取了综合性的干预措施,使肝癌标化发病率下降44.35%,标化死亡率下降44.20%,特别是青年人肝癌发病率(死亡率)的下降,在流行病学、生态学和生物标志物方面均获得了可信的证据。启东肝癌防控的长期实践表明,针对危险因素开展综合防治和干预,完全有可能取得一级预防和二级预防效果。     

启东肺癌流行趋势与危险因素探讨

启东市1958年以来肺癌发病死亡呈显著上升趋势。理论预测2001年后的十年仍继续呈现上升趋势,2008年肺癌发病率男性已达97.41/10万,女性达36.22/10万,实际数据远超预测值。启东市肺癌发病快速增长的主要原因,可能与烟草销售量上升、吸烟率升高以及人口老龄化等有关。因此,必须十分重视肺癌预防研究,制定有效防治对策,尽量降低肺癌发病率和死亡率。     

乙肝疫苗母-婴阻断失败者病毒全基因变异分析

Objective To determine the factors responsible for failed postnatal immunoprophylaxis for hepatitis B virus(HBV) in Qidong, China. Methods Eleven children who developed into chronic HBV infection after receiving HBIG and HBV recombinant vaccines were recruited into the study. Eleven paired mothers with chronic hepatitis and other 6 mothers whose children successfully generated anti-HBs after im-munoprophylaxis were included as the control in the study. Full-length HBV DNA was amplified through ser-um sample by PCR method and underwent cloning and sequencing. HBV DNA level was quantified by real-time PCR. Results The mean levels of HBV DNA in mothers who had HBV DNA positive children and healthy children were ( 1.2 ×107± 3.1 × 106 ) copies/ml and ( 1.6× 107±8.8×106 ) copies/ml, respec-tively. There was no significant difference between the groups (P >0.05). Meanwhile, viral load in chil-dren was unrelated to that in their mothers (r2 =0.2429). In 11 HBV DNA positive children, 4(36.4% ) demonstrated amino acid substitutions in HBsAg "a" determinant region with 6 different types, I.e. T125A, I126T, Q129H, M133V, D144V and G145A. All of the mothers showed the wild-type sequence in "a" epitope, indicating surface escape mutants were not acquired from the initial infection, but developed under the immune pressure. The mutation rates after immunoprophylaxis for preS1, preS2, S, X, preC/C and P genes were 0.38%, 0. 22%, 0.27%, 0.17%, 0.11%, and 0.11%, respectively, nt2999-3157 in preS1, nt529-677 in S, nt1955-2016 in C, nt923-1001 and nt2489-2602 in P genes were among the hottest muta-tional spots throughout the HBV genome. Conclusion HBV mutation may occur in all the open readingframes after passive and active immunoprophylaxis. In addition to S gene, HBV preS and P genes could alsoassociate with the escape mutants.     

复合式小梁切除术治疗青光眼的临床观察

目的观察复合式小梁切除术治疗青光眼的临床疗效。方法选择40例(40眼)青光眼施行复合式小梁切除术作为观察组。随机对照组37例(37眼)行单纯小梁切除术,比较两组术后眼压、滤过泡和前房深度。结果复合式小梁切除术(观察组)术后浅前房发生率较对照组低,术后3个月观察组的功能性滤过泡较对照组多,无严重并发症发生。结论复合式小梁切除术不仅能提高滤过性手术的成功率而且能减少术后并发症的发生。     

江苏省启东地区肝癌患者ABO血型分布及其与肝癌发病风险的关系

目的 了解江苏省启东地区肝癌患者ABO血型分布情况，探讨ABO血型与肝癌发病风险的关系。方法 选择1 701例启东籍肝癌患者、2 828例排除疾病后的启东籍健康体检人员，采集两组外周静脉血检测ABO血型，分析ABO血型与肝癌发生风险的关系。结果 1 701例肝癌患者中，血型为A型者518例（30.45%）、B型者436例（25.63%）、O型者518例（30.45%）、AB型者229例（13.46%）; 2 828例体检健康者中，血型为A型者862例（30.48%）、B型者818例（28.93%）、O型者853例（30.16%）、AB型者295例（10.43%），与健康人群比较，肝癌患者中AB型比例高、B型比例低（P均<0.05）。B型的启东籍人群发生肝癌的风险低（OR=0.847,95%CI:0.739～0.970）,AB型启东籍人群发生肝癌的风险高（OR=1.336,95%CI 1.111～1.606）。与健康人群比较，男性肝癌患者B型比例低、AB型比例高（χ2=5.618,11.01;OR分别为0.809,1.534;P均<0.05）。结论 江苏省启东地区肝癌的发生与...