全文获取类型
收费全文 | 4555篇 |
免费 | 164篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 113篇 |
妇产科学 | 25篇 |
基础医学 | 624篇 |
口腔科学 | 207篇 |
临床医学 | 260篇 |
内科学 | 1047篇 |
皮肤病学 | 64篇 |
神经病学 | 352篇 |
特种医学 | 202篇 |
外科学 | 694篇 |
综合类 | 18篇 |
预防医学 | 177篇 |
眼科学 | 106篇 |
药学 | 349篇 |
中国医学 | 3篇 |
肿瘤学 | 438篇 |
出版年
2023年 | 40篇 |
2022年 | 38篇 |
2021年 | 107篇 |
2020年 | 67篇 |
2019年 | 96篇 |
2018年 | 86篇 |
2017年 | 98篇 |
2016年 | 95篇 |
2015年 | 102篇 |
2014年 | 127篇 |
2013年 | 144篇 |
2012年 | 291篇 |
2011年 | 295篇 |
2010年 | 140篇 |
2009年 | 149篇 |
2008年 | 301篇 |
2007年 | 298篇 |
2006年 | 290篇 |
2005年 | 311篇 |
2004年 | 323篇 |
2003年 | 240篇 |
2002年 | 290篇 |
2001年 | 54篇 |
2000年 | 54篇 |
1999年 | 64篇 |
1998年 | 69篇 |
1997年 | 62篇 |
1996年 | 38篇 |
1995年 | 51篇 |
1994年 | 39篇 |
1993年 | 44篇 |
1992年 | 38篇 |
1991年 | 22篇 |
1990年 | 33篇 |
1989年 | 18篇 |
1988年 | 21篇 |
1987年 | 15篇 |
1986年 | 12篇 |
1985年 | 11篇 |
1984年 | 15篇 |
1983年 | 15篇 |
1982年 | 16篇 |
1981年 | 17篇 |
1980年 | 17篇 |
1979年 | 16篇 |
1978年 | 17篇 |
1977年 | 10篇 |
1971年 | 4篇 |
1968年 | 7篇 |
1967年 | 5篇 |
排序方式: 共有4742条查询结果,搜索用时 17 毫秒
71.
72.
In the process of reading music, the reading of rhythm and pitch might be differentiated, although there is no evidence of this to date. There have been cases of disorders restricted to the reading of pitch, but none in which the disorder has been restricted to the reading of rhythm. We present a case of musical alexia and agraphia with Wernicke’s aphasia. An in-depth assessment of the subject’s musical reading ability showed that her musical alexia was restricted to unfamiliar melodies. When a melody was divided into rhythm elements and pitch elements, pitch reading was preserved, but rhythm reading was severely disturbed. This is the first case reported of a disorder restricted to rhythm reading, and suggests the independence of rhythm reading and pitch reading. 相似文献
73.
Yuki Kato Koichi Masuno Kae Fujisawa Noriko Tsuchiya Mikinori Torii Atsuko Hishikawa Takeshi Izawa Mitsuru Kuwamura Jyoji Yamate 《Experimental and toxicologic pathology》2017,69(7):413-423
We herein investigated the histopathological features, including proliferative activity and immunoexpression, of pancreatic islet cell tumors (ICTs) in male SD rats induced by streptozotocin (STZ) and nicotinamide (NA), and discussed their relevance to biological behaviors and prognoses. A total of 70 and 43% of rats developed ICTs 37–45 weeks after the treatment with STZ (50 or 75 mg/kg, i.v.) and NA (350 mg/kg, twice, p.o.), respectively. Among the islet tumors observed in the STZ/NA-treated groups, 75% were adenomas, while 25% were carcinomas. Most STZ/NA-induced carcinomas were characterized by well-differentiated tumor cells with/without local invasion into the surrounding tissues, and weak proliferative activity. No outcome such as distance metastasis and death was noted. All of the ICTs strongly expressed insulin, part of which had hormone productivity; however there were no hypoglycemia-related clinical signs such as convulsion in these rats 36 weeks after the treatment. These results suggested that rat ICTs induced STZ/NA have small impact on biological activity or prognosis. STZ/NA treatment significantly increased of focal proliferative lesions in the kidney, liver and adrenal glands other than pancreatic islets. Of the STZ/NA-induced kidney tumors, more than 60% were renal cell adenomas, and many of them were basophilic type. The incidence of eosinophilic or clear cell type of tumors was less than 10%, respectively. Immunohistochemical analyses revealed that many of the STZ/NA-induced basophilic type of renal tumors were derived from proximal tubules, whereas the clear cell and eosinophilic types were derived from collecting tubules. 相似文献
74.
Eiji Wada Mitsuru Fukui Kazuhisa Takahashi Daisaku Takeuchi Hiroshi Hashizume Masahiko Kanamori Noboru Hosono Tsukasa Kanchiku Yuichi Kasai Miho Sekiguchi Shin-ichi Konno Mamoru Kawakami Kazuo Yonenobu 《Journal of orthopaedic science》2019,24(1):57-61
Background
In 1999, the Japanese Orthopaedic Association decided to develop a new Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). The final version of the JOACMEQ, comprising 24 questions and five domains (cervical spine function (CF); upper extremity function (UF); lower extremity function (LF); bladder function (BF); and quality of life (QOL)), was established after three nationwide investigations. The fourth investigation, reported in this paper, was performed to confirm the responsiveness of the questionnaire.Methods
A total of 137 patients with cervical myelopathy were included in the study. Each patient was interviewed twice using the JOACMEQ before and after treatment. At the second interview, the patients self-rated their condition in five domains for “worse,” “somewhat worse,” “no change,” “somewhat better,” or “better,” and these scores were defined as the external assessment rating. The difference of the points in five domains between the first and the second interview was calculated against each external assessment. Based on the results, substantial clinical benefit (SCB) thresholds for the JOACMEQ were determined.Results
The statistically significant median values of the acquired points were 17.5 for CF, 16.0 and 21.0 for UF, 27.0 and 20.5 for LF, 13.0 for BF, and 29.0 for QOL. After consideration of the results, the committee decided that an acquired point ≥20 could be interpreted as representing an SCB threshold for the JOACMEQ.Conclusion
We have concluded that a treatment can be judged to be effective for a patient if 1) The patient give all answers for the questions necessary to calculate the functional score of a domain and an increase of ≥20 points is obtained for that score, or 2) The functional score after treatment is > 90 points even if the answer for the unanswered questions was supposed to be the worst possible choice. 相似文献75.
Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification 下载免费PDF全文
76.
Kosuke Nomura Toshiro Iizuka Daisuke Kaji Hisashi Yamamoto Yasutaka Kuribayashi Ryusuke Kimura Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Akira Matsui Toshifumi Mitani Osamu Ogawa Shu Hoteya Yasunori Ota Shuichi Taniguchi Mitsuru Kaise 《Journal of gastroenterology and hepatology》2014,29(11):1867-1872
77.
Microsurgeons rarely encounter a situation that includes multiple downstream arteries requiring reperfusion with only one feeding artery being available. To cope with the difficulty of such a case, a unique microvascular anastomosis is described. This surgical technique is based on the assumption of the presence of a single large outflowing vessel and two small downstream vessels. The axial incisions were made on the cut end of the two small vessels. The ends of the two small vessels were sutured side-to-side and remodeled as one vessel. The partially coalesced small vessels were then anastomosed with the outflowing large vessel in an end-to-end fashion. Case presentation: a crush injury of the foot required reconstruction of the blood flow. The first dorsal metatarsal artery (FDMA) was damaged and occluded by thrombosis. The first and second toes had no blood supply. The original plan was simply to remove the damaged area of the FDMA and replace it with a straight vein graft, as the bifurcation to the two digital arteries appeared to be intact. At the time of microvascular anastomosis, however, the FDMA was found to still be damaged, and it required additional debridement. As a suboptimal method, the vein graft and the two digital arteries were anastomosed by the above-described atypical method. The digits all survived, and the patient subsequently returned to work, with no complications as of 10 months postoperatively. This atypical microvascular anastomosis is not an established method, but it has potential utility in similar situations.Level of Evidence: Level V, therapeutic study. 相似文献
78.
Kavindra Kumara Wijesundera Vetnizah Juniantito Hossain M. Golbar Kae Fujisawa Miyuu Tanaka Chisa Ichikawa Takeshi Izawa Mitsuru Kuwamura Jyoji Yamate 《Experimental and toxicologic pathology》2013,65(6):799-808
Ionized calcium binding adaptor molecule 1 (Iba1) is associated with membrane ruffling and motility of cells. Galectin-3 (Gal-3) is a β-galactoside binding animal lectin, and regulates fibrogenesis probably through transforming growth factor-β1. To evaluate macrophage properties, expressions of Iba1 and Gal-3 were investigated, in relation to macrophages expressing CD68 (ED1; reflecting increased phagocytosis) and CD163 (ED2; implying proinflammatory factor productions) in centrilobular lesions induced in rat livers with thioacetamide (TAA; 300 mg/kg body weight, once intraperitoneally). In agreement with expression patterns of CD68+ and CD163+ macrophages, cells reacting to Iba1 and Gal-3 were increased in numbers on post-injection (PI) days 1–5, peaking on day 2; thereafter, the positive cells gradually decreased to control levels until PI days 7 and 10. The increased expressions of Iba1 and Gal-3 were confirmed at mRNA levels by the RT-PCR. Double immunofluorescence staining on PI days 2 and 3 demonstrated Iba1 expression in 15–46% of CD68+ and CD163+ macrophages, and Gal-3 expression in 65–82% of CD68+ and CD163+ macrophages; Gal-3 expression was observed in 84–93% of Iba1+ cells. Interestingly, Gal-3 was also expressed in a small number of α-smooth muscle actin-positive myofibroblasts in fibrotic lesions developed in injured centrilobular areas. These findings indicate that macrophages with various functions can participate in development of liver lesions and resultant fibrosis. Besides CD68 and CD163, Iba1 and Gal-3 immunohistochemistry for macrophages would be useful to analyze the pathogenesis behind developing hepatotoxicity. 相似文献
79.
Mitsuru Sasako 《The lancet oncology》2014,15(11):1182-1184
80.
Endoscopic ultrasound‐guided antegrade biliary stenting for unresectable malignant biliary obstruction in patients with surgically altered anatomy: Single‐center prospective pilot study 下载免费PDF全文