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61.
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Rupioid lesions,PLEVA and superposition phenomenon in malignant syphilis: two case reports in HIV‐infected patients 下载免费PDF全文
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Involving children and young people in clinical research through the forum of a European Young Persons’ Advisory Group: needs and challenges 下载免费PDF全文
Segolene Gaillard Salma Malik Jenny Preston Begonya Nafria Escalera Pamela Dicks Nathalie Touil Sandrine Mardirossian Joana Claverol‐Torres Behrouz Kassaï 《Fundamental & clinical pharmacology》2018,32(4):357-362
Children and young people are seen as fundamental to the design and delivery of clinical research as active and reflective participants. In Europe, involvement of children and young people in clinical research is promoted extensively in order to engage young people in research as partners and to give them a voice to raise their own issues or opinions and for their involvement in planning and decision making in addition to learning research skills. Children and young people can be trained in clinical research through participation in young person advisory groups (YPAGs). Members of YPAGs assist other children and young people to learn about clinical research and share their experience and point of view with researchers, thereby possibly influencing all phases of research including the development and prioritization of research questions, design and methods, recruitment plans, and strategies for results dissemination. In the long term, the expansion of YPAGs in Europe will serve as a driving force for refining pediatric clinical research. It will help in a better definition of research projects according to the patients’ needs. Furthermore, direct engagement of children and young people in research will be favorable to both researchers and young people. 相似文献
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Joanna d'Arc Lyra Batista Maria de Fátima Pessoa Milit?o de Albuquerque Marcela Lopes Santos Demócrito de Barros Miranda-Filho Heloísa Ramos Lacerda Magda Maruza Libia Vilela Moura Isabella Coimbra Ricardo Arraes de Alencar Ximenes 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(2):127-132
Despite the effectiveness of combination antiretroviral therapy in the
treatment of people living with HIV/AIDS (PLWHA), nonadherence to medication has
become a major threat to its effectiveness. This study aimed to estimate the
prevalence of self-reported irregular use of antiretroviral therapy and the factors
associated with such an irregularity in PLWHA. A cross-sectional study of PLWHA who
attended two referral centers in the city of Recife, in Northeastern Brazil, between
June 2007 and October 2009 was carried out. The study analyzed socioeconomic factors,
social service support and personal habits associated with nonadherence to
antiretroviral therapy, adjusted by multivariable logistic regression analysis. The
prevalence of PLWHA who reported irregular use of combination antiretroviral therapy
(cART) was 25.7%. In the final multivariate model, the irregular use of cART was
associated with the following variables: being aged less than 40 years (OR =
1.66, 95%-CI: 1.29-2.13), current smokers (OR = 1.76, 95%-CI: 1.31-2.37) or
former smokers (OR = 1.43, 95%-CI: 1.05-1.95), and crack cocaine users (OR
= 2.79, 95%-CI: 1.24-6.32). Special measures should be directed towards each
of the following groups: individuals aged less than 40 years, smokers, former smokers
and crack cocaine users. Measures for giving up smoking and crack cocaine should be
incorporated into HIV-control programs in order to promote greater adherence to
antiretroviral drugs and thus improve the quality of life and prolong life
expectancy. 相似文献
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Impact of oral clinical problems on oral health‐related quality of life in brazilian children: a hierarchical approach 下载免费PDF全文
João Gabriel Silva Souza Andréa Maria Eleutério De Barros Lima Martins Marise Fagundes Silveira Kimberly Marie Jones Maria Paula Maciel Rando Meirelles 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2017,27(1):66-78
69.
Indoor fungal diversity in primary schools may differently influence allergic sensitization and asthma in children 下载免费PDF全文
70.
Isabel G. Quirino Jose Silverio S. Diniz Maria Candida F. Bouzada Alamanda K. Pereira Thais J. Lopes Gabriela M. Paix?o Natalia N. Barros Luisa C. Figueiredo Antonio Carlos V. Cabral Ana Cristina Sim?es e Silva Eduardo A. Oliveira 《Clinical journal of the American Society of Nephrology》2012,7(3):444-451