全文获取类型
收费全文 | 42657篇 |
免费 | 1462篇 |
国内免费 | 377篇 |
专业分类
耳鼻咽喉 | 364篇 |
儿科学 | 956篇 |
妇产科学 | 924篇 |
基础医学 | 5642篇 |
口腔科学 | 760篇 |
临床医学 | 3099篇 |
内科学 | 9093篇 |
皮肤病学 | 552篇 |
神经病学 | 4184篇 |
特种医学 | 1727篇 |
外科学 | 6353篇 |
综合类 | 1887篇 |
一般理论 | 35篇 |
预防医学 | 2230篇 |
眼科学 | 445篇 |
药学 | 2980篇 |
28篇 | |
中国医学 | 100篇 |
肿瘤学 | 3137篇 |
出版年
2023年 | 278篇 |
2022年 | 483篇 |
2021年 | 1493篇 |
2020年 | 938篇 |
2019年 | 1298篇 |
2018年 | 2025篇 |
2017年 | 1394篇 |
2016年 | 1830篇 |
2015年 | 1989篇 |
2014年 | 2344篇 |
2013年 | 3021篇 |
2012年 | 3190篇 |
2011年 | 2578篇 |
2010年 | 2316篇 |
2009年 | 1996篇 |
2008年 | 2302篇 |
2007年 | 2268篇 |
2006年 | 2023篇 |
2005年 | 1889篇 |
2004年 | 1738篇 |
2003年 | 1355篇 |
2002年 | 1152篇 |
2001年 | 249篇 |
2000年 | 297篇 |
1999年 | 337篇 |
1998年 | 359篇 |
1997年 | 305篇 |
1996年 | 268篇 |
1995年 | 183篇 |
1994年 | 141篇 |
1993年 | 167篇 |
1992年 | 155篇 |
1991年 | 124篇 |
1990年 | 129篇 |
1989年 | 133篇 |
1988年 | 123篇 |
1987年 | 124篇 |
1986年 | 101篇 |
1985年 | 74篇 |
1984年 | 96篇 |
1983年 | 66篇 |
1982年 | 74篇 |
1981年 | 54篇 |
1980年 | 67篇 |
1978年 | 25篇 |
1977年 | 39篇 |
1976年 | 28篇 |
1971年 | 29篇 |
1970年 | 30篇 |
1968年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
11.
12.
Susanna Zanutto Chiara Maura Ciniselli Antonino Belfiore Mara Lecchi Enzo Masci Gabriele Delconte Massimo Primignani Giulia Tosetti Marco Dal Fante Linda Fazzini Aldo Airoldi Marcello Vangeli Francesca Turpini Giovanni Giuseppe Rubis Passoni Paolo Viaggi Monica Arena Roberta Ilaria Olimpia Motta Anna Maria Cantù Cristiano Crosta Giuseppe De Roberto Francesca Iannuzzi Andrea Cassinotti Valentina Dall'Olio Laura Tizzoni Gabriella Sozzi Emanuele Meroni Luigi Bisanti Marco Alessandro Pierotti Paolo Verderio Manuela Gariboldi 《International journal of cancer. Journal international du cancer》2020,146(4):1164-1173
Colorectal cancer (CRC) screening programs help diagnose cancer precursors and early cancers and help reduce CRC mortality. However, currently recommended tests, the fecal immunochemical test (FIT) and colonoscopy, have low uptake. There is therefore a pressing need for screening strategies that are minimally invasive and consequently more acceptable to patients, most likely blood based, to increase early CRC identification. MicroRNAs (miRNAs) released from cancer cells are detectable in plasma in a remarkably stable form, making them ideal cancer biomarkers. Using plasma samples from FIT-positive (FIT+) subjects in an Italian CRC screening program, we aimed to identify plasma circulating miRNAs that detect early CRC. miRNAs were initially investigated by quantitative real-time PCR in plasma from 60 FIT+ subjects undergoing colonoscopy at Fondazione IRCCS Istituto Nazionale dei Tumori, then tested on an internal validation cohort (IVC, 201 cases) and finally in a large multicenter prospective series (external validation cohort [EVC], 1121 cases). For each endoscopic lesion (low-grade adenoma [LgA], high-grade adenoma [HgA], cancer lesion [CL]), specific signatures were identified in the IVC and confirmed on the EVC. A two-miRNA-based signature for CL and six-miRNA signatures for LgA and HgA were selected. In a multivariate analysis including sex and age at blood collection, the areas under the receiver operating characteristic curve (95% confidence interval) of the signatures were 0.644 (0.607–0.682), 0.670 (0.626–0.714) and 0.682 (0.580–0.785) for LgA, HgA and CL, respectively. A miRNA-based test could be introduced into the FIT+ workflow of CRC screening programs so as to schedule colonoscopies only for subjects likely to benefit most. 相似文献
13.
14.
15.
16.
17.
Sania Amr Magdy Garas Dina N. K. Boulos Doa’a A. Saleh Irene A. Jillson Christopher A. Loffredo 《Journal of substance use》2019,24(3):341-345
Background: Egyptian street youth use substances including tobacco, illicit drugs, and pharmaceutical drugs. To understand the circumstances, including adverse childhood experiences, that place adolescents at risk for engaging in substance use, we conducted in-depth interviews among a sample of Egyptian street children. Methods: From youth residing at or attending Caritas, a non-profit organization, which provides shelter and education to street youth, seven girls and twelve boys, aged 12–18 years, participated in open-ended, in-depth interviews. Results: Eight out of the 19 participants reported family history (early exposure) to substance use; and seven of them were initiated by either a family member (sibling), friend or coworker. Most of the participants reported a history of conflict with or abuse (verbal or physical) by their parents or siblings, or stressful situations at home; they used substance(s) to alleviate their stress. Few attended school, and some were forced to work and help their family. Conclusions: Among Egyptian youth, adverse childhood experiences, such as poverty, child abuse, and family substance use, challenge somewhat susceptible youths and lead them to the path of substance use and addiction. Prevention intervention should be multifaceted, culturally adaptable, and primarily targeting the social environment during childhood. 相似文献
18.
Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina Michele Papa Hans V.Westerhoff 《中国神经再生研究》2019,(2)
The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology. 相似文献
19.
Gordon K. B. Saburov V. O. Koryakin S. N. Gulidov I. A. Fatkhudinov T. Kh. Arutyunyan I. V. Kaprin A. D. Solov’ev A. N. 《Bulletin of experimental biology and medicine》2022,173(2):281-285
Bulletin of Experimental Biology and Medicine - Fast neutron therapy, which previously has demonstrated effective results, but along with a large number of complications, can again be considered a... 相似文献
20.