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排序方式: 共有425条查询结果,搜索用时 65 毫秒
91.
A Ammassari R Murri P Pezzotti M P Trotta L Ravasio P De Longis S Lo Caputo P Narciso S Pauluzzi G Carosi S Nappa P Piano C M Izzo M Lichtner G Rezza A Monforte G Ippolito M d'Arminio Moroni A W Wu A Antinori 《Journal of acquired immune deficiency syndromes (1999)》2001,28(5):445-449
OBJECTIVES: To identify variables predictive of nonadherence to highly active antiretroviral therapy (HAART) and to assess whether self-reported symptoms or medication side effects are related to adherence. DESIGN: Cross-sectional multicenter study Adherence Italian Cohort Naive Antiretrovirals [AdICONA] within the Italian Cohort Naive Antiretrovirals (ICONA). METHODS: Participants receiving HAART completed a 16-item self-administered questionnaire to assess nonadherence in the last 3 days as well as the type and intensity of 24 common HIV- and HAART-related symptoms experienced during the last 4 weeks. RESULTS: From May 1999 to March 2000, 358 persons were enrolled: 22% reported nonadherence and were less likely to have HIV RNA <500 copies/ml (odds ratio = 0.51; 95% confidence interval: 0.31-0.85). Frequency of moderate/severe symptoms or medication side effects in nonadherent participants ranged from 3.6% to 30%. On univariate analysis, nausea, anxiety, confusion, vision problems, anorexia, insomnia, taste perversion, and abnormal fat distribution were significantly associated with nonadherence. Nonadherent persons had a higher mean overall symptom score (12.3 +/- 9.2 versus 8.1 +/- 6.6; p <.001) and mean medication side effect score (2.9 +/- 2.7 versus 1.9 +/- 1.9; p <.001) when compared with adherent participants. In the multivariate analysis, nausea ( p =.003); anxiety ( p =.006); younger age ( p =.007); unemployment ( p <.001); not recalling name, color, and timing of drugs ( p =.009); running out of pills between visits ( p =.002); and being too busy ( p =.03) were independently associated with nonadherence in the last 3 days. CONCLUSIONS: In addition to patient characteristics, medication-related variables, and reasons for nonadherence, patient-reported symptoms and medication side effects were significantly associated with adherence to HAART. 相似文献
92.
Andrea Giacomelli MD Massimiliano Fabbiani MD PhD Ilaria De Benedetto MD Silvia Nozza MD Emanuele Focà MD PhD Benedetto M. Celesia MD PhD Giulia Marchetti MD PhD Cristina Mussini MD Andrea Antinori MD Gabriella d’Ettorre MD PhD Giordano Madeddu MD Alessandra Bandera MD PhD Antonio Muscatello MD Stefano Rusconi MD 《Journal of medical virology》2019,91(10):1891-1895
To assess the impact of genotypic susceptibility score (GSS) on combined antiretroviral therapy (cART) outcomes during primary HIV infection (PHI) we retrospectively enrolled patients with PHI diagnosed between 2008 and 2015 at 9/24 Italian Network ACuTe HIV InfectiON centers. One hundred-seventy-six patients were enrolled. Of these, 55 (32.9%) patients started with more than three drugs and 11 (7.2%) started with a GSS < 3. Regimen's GSS (per 1 point increase) (adjusted odds ratio [aOR], 4.82; 95% confidence interval [CI], 1.62-14.28; P = .005) and baseline HIV-RNA (per 1 log10 increase) (aOR, 2.02; 95% CI, 1.09-3.73; P = .025) resulted associated with early cART initiation. In conclusion, regimen's GSS resulted to be associated to the time to cART initiation during PHI. 相似文献
93.
Antinori S.; Versaci C.; Gholami G.Hossein; Panci C.; Caffa B. 《Human reproduction (Oxford, England)》1993,8(9):1487-1490
Oocyte donation was performed by in-vitro fertilization andembryo transfer in 82 women. The average age of the patientswas 48 years (range 2660), and 71 were over 40 yearsold, with an average follicle stimulating hormone (FSH) valueof 74±14 IU and oestradiol concentration of 30 ±9 pg/ml. Overall 32 clinical pregnancies were achieved, of which21 reached term, three are ongoing, and eight were lost (sixmiscarriages, one abruptio placentae, and one severe gestationalproteinuria hypertension in the second trimester). The 21 termpregnancies produced 26 newborns; one patient who had had threeembryos replaced delivered triplets and three patients had twins.Before the embryo transfer was performed, the endometrium thicknesswas accurately determined by vaginal ultrasound probe. The highestnumber of implanted embryos was reached when the endometriumthickness was 912 mm. 相似文献
94.
95.
Successful fertilization and pregnancy after injection of frozen-thawed round spermatids into human oocytes 总被引:4,自引:3,他引:1
Antinori S; Versaci C; Dani G; Antinori M; Selman HA 《Human reproduction (Oxford, England)》1997,12(3):554-556
The effect of cryopreservation on the integrity and fertilizing capacity of
round spermatids was studied in two azoospermic patients. In December 1995
the patients, both with maturation arrest of spermatogenesis, were
submitted to testicular sperm extraction (TESE) after an extensive
examination of their ejaculate. Only round spermatids were found after
testicular biopsy. Some of the spermatids were isolated and used for a
first injection, while the remainder of the preparation was cryopreserved
for successive cycles. Because of the failure of the first attempt, 3
months later, the same two patients were submitted to a second one. The
frozen preparation was thawed and examined to evaluate the integrity and
the viability of surviving round spermatids. More than 70% of the thawed
spermatids were viable for injection. Fifteen oocytes at metaphase II,
retrieved from the patients' wives, were microinjected with thawed round
spermatids. Eighteen hours after the injection, seven out of 15 oocytes
showed normal fertilization, with the presence of two pronuclei. The
zygotes were cultured to observe embryonic development. After 48 h, six
cleaving embryos had developed to at least the two-cell stage, while one
had arrested at the pronuclear stage. At 72 h, the cleaving embryos showed
further development to the four- to six-cell stage. They were then
transferred into the uterus. After 3 weeks a clinical pregnancy was
established in one patient [beta-human chorionic gonadotrophin (beta HCG)
concentration was 2100 UI]. At 16 weeks of gestation, chromosomic analysis
was performed, which confirmed the presence of a fetus with normal
karyotype. The pregnancy is ongoing.
相似文献
96.
97.
Maria Fusaro Giorgio Munaretto Michela Spinello Maurizio Gallieni 《Nephrology, dialysis, transplantation》2004,19(5):1338-1339
Sir, Recent studies suggest that low dose (2.53.0 mg/kg daily)cyclosporin treatment is an effective, safe and well-toleratedtreatment for atopic dermatitis which is refractory to conventionaltreatment modalities. This treatment can also lead to long-termremission of the disease in some patients [1]. Uraemic pruritus is a distressing disease that is difficultto treat. Its prevalence is high in the dialysis population.An effective treatment of severe uraemic pruritus is needed,as its consequences can 相似文献
98.
99.
Lucia Fassone Antonella Cingolani Maurizio Martini Giuseppe Migliaretti Pier Luigi Oreste Daniela Capello Annunziata Gloghini Daniela Vivenza Riccardo Dolcetti Antonino Carbone Andrea Antinori Gianluca Gaidano Luigi Maria Larocca 《AIDS research and human retroviruses》2002,18(1):19-26
In the present study sequence variations at the C terminus of the Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1), EBV-encoded latent membrane protein 1 (LMP-1), and EBNA-2 and EBNA-3C genes were investigated in 64 cases of EBV-positive AIDS-related diffuse large cell lymphoma (AIDS-DLCL), both systemic (12) and localized primarily to the central nervous system (52), and in 12 cases of EBV-positive AIDS-related Burkitt's lymphoma (AIDS-BL). Sequence analysis of the EBNA-1 C-terminal region led to the distinction of two major unrelated EBV strains, termed strain P (prototype) and strain V (variant), and their related subtypes, namely P-ala, P-thr, V-leu, V-val, and V-pro. Analysis of the LMP-1 gene was performed to assess the frequency of the C-terminus deletion variant, whereas analysis of EBNA-2 and EBNA-3C genes led to the identification of the distribution of the EBV type 1 and type 2 strains. The frequency of EBNA-1 subtypes was assessed in 49 cases of AIDS-NHL, including 37 cases of AIDS-DLCL and 12 cases of AIDS-BL. The P strain was detected in 45 of 49 cases (91.8%) whereas the V strain was found in 4 of 49 samples (8.1%). A significant difference in the distribution of the P and V strains was found between AIDS-DLCL and AIDS-BL (p < 0.01), because of the exclusive infection by the P strain of the AIDS-DLCL samples analyzed. The frequency of LMP-1 deletion variants and of EBV type 1 and type 2 strains in AIDS-DLCL overlapped with that of the general population, and no correlation was found with the evaluated clinicoepidemiological data of patients, that is, disease site, tumor histology, CD4(+) cell counts, and HIV transmission route. In conclusion, we found that the distribution of the EBV genotype in all of the AIDS-NHL samples analyzed is similar to the viral representation found in control individuals of both immunocompetent and immunocompromised populations. 相似文献
100.