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61.
Comparison of hospital outcomes and resource use in acute COPD exacerbation patients managed by teaching versus nonteaching services in a community hospital 下载免费PDF全文
62.
The term hemorrhoids in generally used to describe “symptomatic hemorrhoids”. A Medline review of the literature on anatomy,
physiology and post-hemorrhoidectomy changes was performed and summarized in this review.
Received: 19 October 2001 / Accepted: 10 November 2001 相似文献
63.
Metformin and its Effects on Myocardial Dimension and Left ventricular hypertrophy in Normotensive patients with Coronary Heart Disease (The MET‐REMODEL Study): Rationale and Design of the MET‐REMODEL Study 下载免费PDF全文
64.
T A Augustine M Baig A Sood T Budagov G Atzmon J M Mariadason S Aparo R Maitra S Goel 《British journal of cancer》2015,112(2):313-318
Background:
Telomeres are TTAGGG tandem repeats capping chromosomal ends and partially controlled by the telomerase enzyme. The EGFR pathway putatively regulates telomerase function, prompting an investigation of telomere length (TL) and its association with anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (mCRC).Methods:
Colorectal cancer cell lines were treated with multiple drugs and sensitivity determined. Clinical information was gathered from 75 patients who had received anti-EGFR drugs. Telomere length was measured using a validated qRT–PCR technique.Results:
In CRC cell lines, TL independently predicted cetuximab sensitivity. Cells with shorter TL had growth inhibition of 18.6±3.41% as compared with 41.39±8.58% in longer TL (P=0.02). These in vitro findings were validated clinically, in a robust multivariate model. Among patients with KRas WT tumours, those with longer TL had a superior median progression-free survival (PFS) of 24.9 weeks than those with shorter TL; median 11.1 weeks, HR 0.31; P=0.048.Conclusion:
Telomere length could be a potential unique biomarker predictive of clinical benefit (PFS) of mCRC patients treated with anti-EGFR therapy. This is the novel demonstration of a complex hitherto undescribed interaction, placing anti-EGFR therapy, EGFR pathway, and the telomerase complex within a clinical context. 相似文献65.
66.
Shaik Mohammed Asif Naheeda Shaik Bhavna Barthunia Sultan Mohammed Kaleem M Zakirulla Mohammed Zahir Kota Fawaz Abdul Hamid Baig 《BMC oral health》2018,18(1):227
Background
Gingival enlargement due to calcium channel blockers is a common complaint reported by patients. It can be localized or generalized and can range from mild to severe, affecting patients appearance and function. Nifedipine induced gingival enlargement is noticed only in 10 % of patients and very few cases of Nifedipine induced gingival enlargement in an edentulous patient have been documented in the literature.Case presentation
Here in, we report a case of gingival enlargement in a 70?year old hypertensive edentulous patient who was on low dose Nifedipine therapy. Patient wanted complete dentures. We planned to excise the overgrowth and followed up for 1 year.Conclusion
Nifedipine induced gingival enlargement noticed only in 10 % of patients. Hence, there is a need for physicians and dentist to make a coordinated treatment plan and practice care while prescribing these drugs which are associated with gingival overgrowth.67.
68.
69.
Kapasi M Baath J Mintsioulis G Jackson WB Baig K 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2012,47(4):344-347
ObjectiveTo compare the visual outcomes of patients with keratoconus treated with either phototherapeutic keratectomy (PTK) or mechanical epithelial removal prior to corneal collagen crosslinking (CXL).DesignComparative study.ParticipantsThe records of 34 patients (34 eyes) who had PTK (17 eyes) or mechanical (17 eyes) epithelial removal prior to CXL for keratoconus were reviewed retrospectively.MethodsCXL was performed by 1 of 3 surgeons (G.M., W.B.J., or K.B.). Of the eyes, 17 had undergone mechanical epithelial removal prior to CXL and were consecutively selected, after matching with the 17 eyes in the PTK group, for the variables of procedure date, average keratometry, and pachymetry. All eyes had central cones. Manifest refraction spherical equivalent, sphere, cylinder, best-corrected distance visual acuity, and pachymetry were measured and compared preoperatively and in follow-up.ResultsThe mean change between the pre- and postoperative manifest refraction spherical equivalent for the PTK and mechanical groups was 1.68 ± 0.80 and 0.26 ± 0.90, respectively (p < 0.05). The mean change between pre- and postoperative cylinder for the PTK and mechanical groups was 0.53 ± 0.28 and 0 ± 0.18, respectively (p < 0.05). The mean number of lines of improvement in the PTK and mechanical groups were 0.33 ± 0.82 and ?0.58 ± 0.45 lines, respectively (p > 0.05).ConclusionsEarly results suggest that CXL with laser epithelial removal is superior to CXL with mechanical epithelial removal because it reduces refractive error in qualified patients. Although not statistically significant, there was also a trend for PTK CXL patients to have better visual outcomes. 相似文献
70.
Efficacy of coronary artery bypass grafting is well accepted, but its role in octogenarians remains unclear. Therefore, quality of life was evaluated in 73 consecutive octogenarians who underwent coronary artery bypass grafting (1996 to 2001) with data collected in terms of age, gender, New York Heart Association status, co-morbidities, and intra- and postoperative complications. Quality of life was evaluated by a standardized questionnaire to assess postoperative outcomes in terms of functional status (Karnofsky scale), morbidity, and mortality. 相似文献