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排序方式: 共有570条查询结果,搜索用时 46 毫秒
71.
The ductus arteriosus in the newborn infant at high altitude 总被引:2,自引:0,他引:2
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75.
Emtiaz S Carames J Gamboa I de Sousa ML Dias B 《The Journal of prosthetic dentistry》2005,93(5):488-493
Implant concepts continue to evolve not only in terms of materials, surfaces, and designs but also in clinical experience and technical management. This article presents a clinical and laboratory procedure describing how to plan, ensure, and achieve proper spatial dimension in fabricating definitive implant-supported prostheses with the use of 3 different matrices. This will in turn aid in restoring the patient with a predictable outcome from the outset of the treatment. 相似文献
76.
The relationship between emotional intelligence and initial response to a standardized periodontal treatment: a pilot study 总被引:1,自引:0,他引:1
OBJECTIVES: Emotional intelligence (EI) is a psychological construct, which has been proposed as a measure of coping mechanisms. The aim of this pilot study was to investigate the relationship between different domains of EI, and initial response to a simplified non-surgical treatment protocol in 29 patients with chronic periodontitis. METHODS: Assessment of patients included socio-demographic and behavioural variables and assessment of EI. Clinical assessment included measurement of plaque and gingival bleeding. Patients received oral hygiene instruction (OHI) and supra-gingival scaling and polishing over two visits, and re-assessed after 3 weeks. RESULTS: There was a significant overall reduction in plaque and bleeding. Plaque reduction was positively associated with the EI construct of intentionality, resilience, constructive discontent and personal power (Spearman's rank test). Reduction in bleeding was positively correlated with resilience, constructive discontent and intuition. CONCLUSIONS: This pilot study demonstrated an association between EI domains and short-term changes in plaque and bleeding, and suggest that initial responses to standardized periodontal treatment may be partly related to EI. 相似文献
77.
Skeletal muscle adaptation to chronic hypoxia includes loss of oxidative capacity and decrease in fiber size. However, the
diaphragm may adapt differently since its activity increases in response to hypoxia. Thus, we hypothesized that chronic hypoxia
would not affect endurance, mitochondrial function, or fiber size in the mouse diaphragm. Adult male mice were kept in normoxia
(control) or hypoxia (hypoxia, FIO2 = 10%) for 4 weeks. After that time, muscles were collected for histological, biochemical, and functional analyses. Hypoxia
soleus muscles fatigued faster (fatigue index higher in control, 21.5 ± 2.6% vs. 13.4 ± 2.4%, p < 0.05), but there was no difference between control and hypoxia diaphragm bundles. Mean fiber cross-sectional area was unchanged
in hypoxia limb muscles, but it was 25% smaller in diaphragm (p < 0.001). Ratio of capillary length contact to fiber perimeter was significantly higher in hypoxia diaphragm (28.6 ± 1.2
vs. 49.3 ± 1.4, control and hypoxia, p < 0.001). Mitochondrial respiration rates in hypoxia limb muscles were lower: state 2 decreased 19%, state 3 31%, and state
4 18% vs. control, p < 0.05 for all comparisons. There were similar changes in hypoxia diaphragm: state 3 decreased 29% and state 4 17%, p < 0.05. After 4 weeks of hypoxia, limb muscle mitochondria had lower content of complex IV (cytochrome c oxidase), while
diaphragm mitochondria had higher content of complexes IV and V (F
1/F
0 ATP synthase) and less uncoupling protein 3 (UCP-3). These data demonstrate that diaphragm retains its endurance during chronic
hypoxia, apparently due to a combination of morphometric changes and optimization of mitochondrial energy production. 相似文献
78.
Gamboa O Montero C Mesa L Benavides C Reino A Torres RE Castillo JS 《Transplantation proceedings》2011,43(9):3367-3376
Background
Renal replacement therapies which consist of renal transplantation and dialysis are the only treatment options for patients with terminal renal failure. These therapies have changed the outcome from being fatal to being a chronic disease. Kidney transplantation involves the use of immunosuppressive agents to prevent rejection. Currently, several immunosuppressive agents have shown efficacy, safety, and different costs.Objective
The aim was to evaluate the cost-effectiveness of early conversion from tacrolimus to mammalian target of rapamycin inhibitors sirolimus or everolimus versus continuous treatment with tacrolimus among renal transplantat patients in Colombia.Methods
We performed systematic literature review to extract data for clinical effectiveness and safety of tacrolimus replacement schemes for immunosuppressive therapy in renal transplantation in adults. A Markov model in TreeAge was developed, simulating the patient's natural history with renal transplantation. The perspective of the Colombian Health System was used, including only direct costs. The cost-effectiveness ratio and incremental cost-effectiveness ratio were estimated. Deterministic and probabilistic sensitivity analyses were performed. A 5% discount rate was applied in costs and health results.Results
Results for the replacement of tacrolimus to sirolimus are provided. The cost per year of additional life gained for sirolimus was Col$2,441,171.43; the cost for avoided loss was Col$4,014,152.84. The acceptability curve shows that a strategy with sirolimus is the most cost-effective one.Conclusions
This study suggested that the sirolimus strategy is cost-effective in Colombia for patients with renal transplantation using as threshold less than three times the gross domestic product (GDP) per capita of Colombia per life of years gained. 相似文献79.
Shibao C Gamboa A Diedrich A Biaggioni I 《Current treatment options in cardiovascular medicine》2006,8(2):105-109
Opinion statement Supine hypertension is a common finding in patients with autonomic failure; it is associated with end-organ damage and produces
nighttime pressure diuresis with worsening of orthostatic hypotension. During the daytime, it is best treated by avoiding
the supine posture. At night, simple measures such as raising the head of the bed by 6 to 9 inches can be effective, but most
patients require pharmacologic treatment. Transdermal nitroglycerin (0.1 to 0.2 mg/h) or nifedipine (30 mg, orally) has proved
to be effective. Hydralazine and minoxidil are usually less effective but may be useful in a given patient. One key therapeutic
concept is the hypersensitivity of these patients to depressor agents, requiring a careful titration of the doses on an individual
basis. For those patients with proven residual sympathetic tone, as in multiple system atrophy, central sympatholytics such
as clonidine may provide an alternative. 相似文献
80.
Fatal CNS vasculopathy in a patient with refractory celiac disease and lymph node cavitation 总被引:1,自引:0,他引:1
Keller CE Gamboa ET Hays AP Karlitz J Lowe G Green PH Bhagat G 《Virchows Archiv : an international journal of pathology》2006,448(2):209-213
Celiac disease is an enteropathy occurring in genetically predisposed individuals due to a dietary intolerance to gluten.
Patients with celiac disease may develop a neurological disorder of unknown cause, although autoimmune mechanisms are suspected.
We report on a 56-year-old man with celiac disease, who became refractory to a gluten-free diet and died of a rapidly progressive
encephalopathy. Magnetic resonance imaging indicated focal lesions of the cerebellum and brainstem, and electrodiagnostic
studies suggested an axonal neuropathy. Autopsy revealed a flattened small-bowel mucosa with intraepithelial lymphocytosis,
a spectrum of degenerative changes of the intra-abdominal and mediastinal lymph nodes, including cavitary degeneration, and
splenomegaly. Histologically, the lymph nodes showed pseudocyst formation and lymphocytic vasculitis with fibrinoid necrosis,
and sections of the brain exhibited fibrinoid degeneration of small blood vessels, sparse perivascular lymphocytic infiltrates,
and perivascular ischemic lesions. Identical T-cell clones were identified in the duodenum, stomach, lymph nodes, and spleen.
This patient had an unusual neurological disorder related to a vasculopathy, probably mediated by a circulating neoplastic
clone of activated T cells. 相似文献