全文获取类型
收费全文 | 10049篇 |
免费 | 667篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 140篇 |
儿科学 | 289篇 |
妇产科学 | 140篇 |
基础医学 | 1407篇 |
口腔科学 | 933篇 |
临床医学 | 727篇 |
内科学 | 2372篇 |
皮肤病学 | 181篇 |
神经病学 | 772篇 |
特种医学 | 231篇 |
外国民族医学 | 2篇 |
外科学 | 954篇 |
综合类 | 45篇 |
一般理论 | 4篇 |
预防医学 | 1001篇 |
眼科学 | 134篇 |
药学 | 780篇 |
中国医学 | 60篇 |
肿瘤学 | 580篇 |
出版年
2023年 | 96篇 |
2022年 | 96篇 |
2021年 | 401篇 |
2020年 | 242篇 |
2019年 | 314篇 |
2018年 | 371篇 |
2017年 | 270篇 |
2016年 | 327篇 |
2015年 | 366篇 |
2014年 | 462篇 |
2013年 | 542篇 |
2012年 | 874篇 |
2011年 | 850篇 |
2010年 | 476篇 |
2009年 | 388篇 |
2008年 | 636篇 |
2007年 | 632篇 |
2006年 | 554篇 |
2005年 | 477篇 |
2004年 | 415篇 |
2003年 | 356篇 |
2002年 | 314篇 |
2001年 | 139篇 |
2000年 | 157篇 |
1999年 | 142篇 |
1998年 | 59篇 |
1997年 | 57篇 |
1996年 | 41篇 |
1995年 | 24篇 |
1994年 | 30篇 |
1993年 | 21篇 |
1992年 | 64篇 |
1991年 | 56篇 |
1990年 | 48篇 |
1989年 | 51篇 |
1988年 | 44篇 |
1987年 | 34篇 |
1986年 | 38篇 |
1985年 | 45篇 |
1984年 | 34篇 |
1983年 | 25篇 |
1982年 | 13篇 |
1981年 | 16篇 |
1980年 | 17篇 |
1979年 | 11篇 |
1978年 | 13篇 |
1976年 | 12篇 |
1975年 | 16篇 |
1970年 | 9篇 |
1968年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Flavio Roberto Takeda Marcus Fernando Kodama Pertille Ramos Marina Alessandra Pereira Renan Rosetti Muniz Francisco Tustumi Tiago Biachi de Castria Rubens Antonio Aissar Sallum Bruno Zilberstein Ulysses Ribeiro Junior Ivan Cecconello 《American journal of surgery》2021,221(3):631-636
IntroductionAdenocarcinoma of the esophagogastric junction (AEGJ) represents a poor prognostic tumor. We evaluated the recurrence pattern and risk factors associated with recurrence in patients undergoing surgical resection by AEJG.MethodsRecurrences were categorized as locoregional, peritoneal, or distant. These three recurrence groups and a non-recurrence group were compared, and overall survival (OS) and disease-free survival (DFS) for each one was obtained.ResultsWe analyzed 188 patients with curative surgical treatment. Recurrence was observed in 72 (38.3%) patients. Locoregional recurrence was observed in 17 (23.6%); 20 (27.8%) peritoneal recurrence and 35 (48.6%) distant metastasis. DFS was 9, 5, and 8 months, and OS was 21.8, 13.2, and 20.8, respectively. Tumors larger than 5 cm are risk factors for peritoneal recurrence (OR:2.88, p = 0.012). Positive lymph nodes were related to distant metastasis (OR:9.15, p = 0.040), and lymphatic invasion for locoregional recurrence (OR:3.81, p = 0.028).ConclusionAEGJ is associated with high rates of early recurrence. 相似文献
92.
Marina Guitton Rodrigues Paula Marcela Vilela Castro Tiago Careli de Almeida Fernanda Ribeiro Danziere Francisco Antonio Sergi Filho Beimar Edmundo Zeballos Sempertegui Juan Rafel Branez Leonardo Toledo Mota Marcelo Perosa de Miranda Regina Gomes dos Santos Tércio Genzini 《Transplantation proceedings》2021,53(2):661-664
ObjectiveThis study aimed to evaluate how cold ischemia time (CIT) interferes with liver graft function in the first 7 days after surgery for Custodiol (HTK) preserved organs.MethodsThis retrospective observational study analyzed the medical records of 38 transplantation patients at Hospital Leforte Liberdade, São Paulo, in 2018. The study population was divided into 2 groups (group A, CIT < 8 hours; group B, CIT > 8 hours). Postoperative parameters—such as international normalized ratio, total bilirubin, aspartate aminotransferase/alanine aminotransferase, alkaline phosphatase, gamma glutamyl transferase (GGT), lactate dehydrogenase, lactate, creatinine, red blood cell transfusion, need for hemodialysis, use of vasoactive drugs, endotracheal intubation time, length of stay in the intensive care unit (ICU), and length of hospital stay—were compared.ResultsGroup A (CIT < 8 hours) presented less need for red blood cell transfusions (odds ratio 0.29; confidence interval 0.06-0.98; P = .04), had a shorter hospital stay (P = .024), and had lower levels of total bilirubin (P = .05) and GGT (P = .05) in the first 7 postoperative days. The other variables showed no statistically significant difference.ConclusionIn livers preserved with Custodiol, CIT > 8 hours generated higher levels of total bilirubin and GGT in the postoperative period, in addition to higher hospital costs; greater need for red blood cell transfusions; and longer hospitalization, including longer stays in the ICU. 相似文献
93.
94.
95.
Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz JM Grezzana-Filho Fl via Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cl ber Rosito Pinto Kruel 《World journal of gastrointestinal surgery》2021,13(3):315-322
BACKGROUNDPrimary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect. Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care. However, under specific circumstances, a cytoreductive approach may represent a therapeutic option. We describe herein the case of an 84-year-old woman who presented with a tender, protruding epigastric mass. Abdominal computed tomography scan revealed a large, heterogeneous mass located across segments III, IV, V, and VIII of the liver. The initial approach was transarterial embolization of the tumor, which elicited no appreciable response. Considering the large size and central location of the tumor and the advanced age of the patient, non-anatomic complete resection was indicated. Due to substantial intraoperative bleeding and hemodynamic instability, only a near-complete resection could be achieved. Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver. Considering the risk/benefit ratio for therapeutic options, debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARYHere, we present a case report of a patient diagnosed with E-GIST primary of the liver, which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSIONE-GIST primary of the liver is a rare conditional, the treatment is with systemic therapy and total resection surgery. However, a cytoreductive surgery will be necessary when a complete resection is no possible. 相似文献
96.
Knorst Jessica Klöckner Brondani Bruna Tomazoni Fernanda Vargas Andressa Weber Cósta Marina Dutra da Silva Godois Leonardo Mendes Fausto Medeiros Ardenghi Diego Machado Ardenghi Thiago Machado 《Quality of life research》2021,30(6):1685-1691
Quality of Life Research - As people around the world are facing the Covid-19 outbreak, their perception of oral health problems could be changed. This study aimed to evaluate the immediate effects... 相似文献
97.
Pathak Anupa Sharma Saurab Heinemann Allen W. Stratford Paul W. Ribeiro Daniel Cury Abbott J. Haxby 《Quality of life research》2021,30(2):613-628
Quality of Life Research - The Patient-Specific Functional Scale (PSFS) is a routinely used measure of physical function with a 0–10 response scale. We aimed to develop verbal response... 相似文献
98.
M. Djindjian A. Ribeiro E. Ortega A. Gaston J. Poirier 《Surgical and radiologic anatomy : SRA》1988,10(3):201-209
Summary The arterial and venous blood-supply of the intradural filum terminale was studied microscopically in 18 fresh cadavers after removing the dorsolumbar spinal cord in one piece, with the roots and the filum in their dural sheath. The arteries were examined after manual injection of the artery of the lumbar enlargement, while study of the veins was made without injection since their bluish-black color made them easily identifiable. After gross examination, each specimen was fixed and then sectioned at 12 different levels from the medullary conus to the bottom of the dural sac for histologic study. The distribution of the vascularization the filum terminale appeared constant. A single artery, the artery of the filum, arises from the termination of the anterior spinal axis, either by trifurcation or from the proximal part of one of the 2 branches of the anastomotic ansa of the conus. The artery travels in front of the filum, with rapidly diminishing caliber; rarely, it can be followed into the sacral canal. The vein of the filum travels in front of that structure but behind the artery, as in the cord; its caliber is uniform but varies from subject to subject. It traverses the dura below and continuous with the anterior spinal vein above. No vessels were found on the dorsal aspect of the filum. While the artery of the filum is of a caliber proportional to that of the filum and appears to be a nutrient vessel, the vein has a caliber unrelated to that of the filum and appears rather as an intradural drainage route continuous with the anterior spinal vein. Several cases of disease of the filum terminale confirm this anatomic appearance and also show that, because of the existing hyperpressure in the vein of the filum, the posterior spinal vein also shares in the drainage of the latter and that entire system may function in both ascending and descending directions.
La vascularisation normale du filum terminale intradural chez l'homme
Résumé La vascularisation artérielle et veineuse du filum terminale intradural a été étudiée sur 18 cadavres frais, sous microscope, après prélèvement en monobloc de la moelle épinière dorso-lombaire, des racines et du filum dans leur étui dural. L'examen des artères a été fait après injection manuelle de l'artère du renflement lombaire, tandis que l'étude des veines s'est faite sans injection compte tenu d'une coloration bleu-noir spontanée qui les rendent aisément identifiables. Après étude macroscopique, chaque pièce a été fixée, puis coupée à 12 niveaux différents depuis le cône médullaire jusqu'au fond du cul-de-sac dure-mérien, pour étude histologique. La distribution de la vascularisation du FT apparaît constante. Une artère unique, l'artère du FT, naît de la terminaison de l'axe spinal antérieur, soit par trifurcation, soit de la partie proximale d'une des 2 branches de l'anse anastomotique du cône. L'artère chemine devant le FT; son calibre diminue rapidement; rarement, elle a pu être suivie jusque dans le canal sacré. Une veine, la veine du FT, chemine en avant du FT mais en arrière de l'artère, comme au niveau médullaire. Son calibre est uniforme mais variable d'un sujet à l'autre. Elle traverse la dure-mère en bas; elle se continue avec la veine spinale antérieure en haut. Aucun vaisseau n'a été retrouvé à la face dorsale du FT. Si l'artère du FT a un calibre qui est proportionnel à celui du filum et apparaît comme un vaisseau nourricier, la veine a un calibre sans aucun rapport avec le volume de celui-ci et apparaît davantage comme une voie de drainage intradural en continuité avec la veine spinale antérieure. Quelques cas de pathologie du FT confirment cet aspect anatomique et montrent aussi qu'en raison de l'hyperpression veineuse régnant dans la veine du FT, la veine spinale postérieure participe également au drainage de celle-ci et que l'ensemble peut fonctionner dans les 2 sens ascendant ou descendant.相似文献
99.
Chlorhexidine susceptibility and Eagle effect in planktonic cells and biofilm of nosocomial isolates
Marchi Ana Paula Farrel Côrtes Marina Vásconez Noguera Saidy Rossi Flavia Levin Anna Sara Figueiredo Costa Silvia Perdigão Neto Lauro Vieira 《European journal of clinical microbiology & infectious diseases》2023,42(6):787-792
European Journal of Clinical Microbiology & Infectious Diseases - The aim of this study is to evaluate the chlorhexidine gluconate (CHG) susceptibility in both planktonic cells and biofilm of... 相似文献