全文获取类型
收费全文 | 9332篇 |
免费 | 949篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 116篇 |
儿科学 | 306篇 |
妇产科学 | 273篇 |
基础医学 | 1390篇 |
口腔科学 | 236篇 |
临床医学 | 983篇 |
内科学 | 1852篇 |
皮肤病学 | 66篇 |
神经病学 | 854篇 |
特种医学 | 302篇 |
外科学 | 1311篇 |
综合类 | 202篇 |
一般理论 | 5篇 |
预防医学 | 766篇 |
眼科学 | 463篇 |
药学 | 682篇 |
中国医学 | 12篇 |
肿瘤学 | 498篇 |
出版年
2023年 | 38篇 |
2021年 | 187篇 |
2020年 | 112篇 |
2019年 | 189篇 |
2018年 | 192篇 |
2017年 | 145篇 |
2016年 | 163篇 |
2015年 | 196篇 |
2014年 | 260篇 |
2013年 | 352篇 |
2012年 | 539篇 |
2011年 | 632篇 |
2010年 | 341篇 |
2009年 | 297篇 |
2008年 | 571篇 |
2007年 | 625篇 |
2006年 | 576篇 |
2005年 | 518篇 |
2004年 | 571篇 |
2003年 | 449篇 |
2002年 | 438篇 |
2001年 | 114篇 |
2000年 | 124篇 |
1999年 | 131篇 |
1998年 | 106篇 |
1997年 | 98篇 |
1996年 | 83篇 |
1995年 | 74篇 |
1994年 | 90篇 |
1993年 | 65篇 |
1992年 | 87篇 |
1991年 | 76篇 |
1990年 | 55篇 |
1989年 | 69篇 |
1988年 | 59篇 |
1987年 | 63篇 |
1986年 | 79篇 |
1985年 | 96篇 |
1984年 | 61篇 |
1983年 | 60篇 |
1982年 | 75篇 |
1981年 | 77篇 |
1980年 | 59篇 |
1979年 | 65篇 |
1978年 | 58篇 |
1977年 | 51篇 |
1976年 | 40篇 |
1974年 | 43篇 |
1973年 | 40篇 |
1972年 | 45篇 |
排序方式: 共有10000条查询结果,搜索用时 437 毫秒
11.
12.
Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-alpha : Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro 总被引:7,自引:2,他引:5
13.
Janice F. Munro Debra Haire-Joshu Edwin B. Fisher H. James Wedner 《The Journal of asthma》1996,33(5):313-325
Low-income minority patients from East St. Louis, Illinois, a depressed midwestern urban city, who had visited acute care settings with asthma symptoms, participated in a focus group. Questions were constructed around the Health Belief Model to characterize participants' experiences in receiving asthma care, their confidence in long-term asthma self-management, barriers they perceived to managing their asthma, and recommendations they would make for improving asthma care in their community. Analysis of comments suggests an appreciable understanding of asthma triggers, limited coping behaviors for asthma symptoms, very limited practice of active asthma management, perception of the health care system as frequently insensitive to their needs or their knowledge of their own care, exchange of well-articulated information regarding how to deal with the system, and an apparent lack of awareness of any potential contribution of patient education or support system. 相似文献
14.
Eileen J. Martin Kiran S. Panickar Michael A. King Malgorzata Deyrup Bruce E. Hunter Geehuan Wang Edwin M. Meyer 《Drug development research》1994,31(2):135-141
The potential cytoprotective actions of a novel nicotinic agent 2,4-dimethoxybenzilidene anabaseine (DMXB) were investigated in differentiated PC12 cells and transected rat septal cholinergic neurons in vivo. In NGF-differentiated PC12 cells, removal of both NGF and serum led to cell loss, a reduced % of cells expressing neurites, the release of lactate dehydrogenase, and a decrease in total cellular protein. Cell loss was apparent within 24 h, and remained constant between 4–8 days post-NGF removal. NGF alone (100 ng/ml), DMXB (10 μM), but not nicotine (10 μM), prevented these cell and neurite losses. DMXB-induced cytoprotection was blocked by 1 μM mecamylamine. DMXB (1 mg/kg, ip) injected twice but not once per day protected cholinesterase-staining septal neurons from retrograde degeneration following unilateral fimbrial transections. The twice per day DMXB injection-protocol also decreased cell roundness among cholinesterase-staining cells in the lesioned septal hemisphere compared to saline-injected animals. These studies suggest that DMXB may exert cytoprotective activity in NGF-sensitive neuronal populations. © 1994 Wiley-Liss, Inc. 相似文献
15.
Toxic-shock-syndrome toxin-1 (TSST-1), a 22-kilodalton (kDa) polypeptide, was proteolyzed by papain, generating three distinct fragments, identified as 16, 12, and 10 kDa (based on molecular masses estimated from the predicted amino acid sequence). The NH2-terminal sequence analysis of the fragments indicated that the peptide bonds between Tyr-52 and Ser-53 and between Gly-87 and Val-88 were cleaved. Functional activity, evaluated through enzyme-linked immunosorbent and inhibition assays, was demonstrated only with the 16- and 12-kDa fragments. The presence of homologous and heterologous antigenic determinants on the fragments was demonstrated by immunoblotting. In in vitro stimulation of human peripheral blood mononuclear cells, the 12-kDa fragment was significantly (P = .003) more active than the 16-kDa fragment. The former composed 75% of the latter and occupied the COOH-terminal portion of the holotoxin. The functional domains were located on two-thirds of the TSST-1 molecule, toward the COOH-terminal end, and mitogenicity apparently was separable from serological activity. 相似文献
16.
17.
Edwin D. Boudreaux PhD Brian L. Cruz MD Brigitte M. Baumann MD 《Academic emergency medicine》2006,13(7):795-802
Objectives: The authors reviewed the evidence on performance improvement methods for increasing emergency department (ED) patient satisfaction to provide evidence-based suggestions for clinical practice.
Methods: Data sources consisted of searches through MEDLINE, CINAHL, PSYCHINFO, Cochrane Library, and Emergency Medicine Abstracts and a manual search of references. Articles were included if they reported a performance improvement intervention targeting patient satisfaction in the ED setting. Articles on studies not conducted in the United States or that failed to provide enough details to allow critical evaluation of the study were excluded. Two authors used structured evaluation criteria to independently review each retained study.
Results: Nineteen articles met all selection criteria. Three studies found varying levels of support for multicomponent interventions, predominantly focused on implementation of clinical practice guidelines for specific presenting complaints and process redesign. Sixteen studies evaluated single-component interventions, with the following having at least one supportive study: using alternating patient assignment to provider teams rather than "zone"-based assignment, enhancing provider communication and customer service skills, incorporating information delivery interventions (e.g., pamphlets, video) that target patient expectations, using preformatted charts, and establishing ED-based observation units for specific conditions such as asthma and chest pain.
Conclusions: There is modest evidence supporting a range of performance improvement interventions for improving ED patient satisfaction. Further work is needed before specific, evidence-based recommendations can be made regarding which process changes are most effective. Recommendations are made for improving the quality of performance improvement efforts in the ED setting. 相似文献
Methods: Data sources consisted of searches through MEDLINE, CINAHL, PSYCHINFO, Cochrane Library, and Emergency Medicine Abstracts and a manual search of references. Articles were included if they reported a performance improvement intervention targeting patient satisfaction in the ED setting. Articles on studies not conducted in the United States or that failed to provide enough details to allow critical evaluation of the study were excluded. Two authors used structured evaluation criteria to independently review each retained study.
Results: Nineteen articles met all selection criteria. Three studies found varying levels of support for multicomponent interventions, predominantly focused on implementation of clinical practice guidelines for specific presenting complaints and process redesign. Sixteen studies evaluated single-component interventions, with the following having at least one supportive study: using alternating patient assignment to provider teams rather than "zone"-based assignment, enhancing provider communication and customer service skills, incorporating information delivery interventions (e.g., pamphlets, video) that target patient expectations, using preformatted charts, and establishing ED-based observation units for specific conditions such as asthma and chest pain.
Conclusions: There is modest evidence supporting a range of performance improvement interventions for improving ED patient satisfaction. Further work is needed before specific, evidence-based recommendations can be made regarding which process changes are most effective. Recommendations are made for improving the quality of performance improvement efforts in the ED setting. 相似文献
18.
Canadian Journal of Anesthesia/Journal canadien d'anesthésie - 相似文献
19.
Edwin H. Preston Jimmy A. Light Robert L. Kampen Allan D. Kirk 《American journal of transplantation》2004,4(2):283-285
Passenger leukocytes have been suggested to be both pro-tolerant and immunogenic. The opportunity to evaluate the role of allogeneic passenger leukocytes in humans was presented by a 47-year-old man who donated bone marrow to his HLA-identical leukemic sister. Eleven years later he developed renal failure. The sister's marrow was noted to be 100% XY karyotype and free of malignancy. She donated a kidney to her brother. Immunosuppression was tapered following transplantation. After 6 months, the recipient was on monotherapy sirolimus, 1 mg every third day. A surveillance biopsy was normal and sirolimus was stopped. Eight weeks later, he presented with severe rejection that reversed with Thymoglobulin. Renal function returned to baseline and has been stable on conventional immunosuppression. 相似文献
20.