Non-A, non-B hepatitis and antibody to hepatitis C virus

Stored serum samples from the Transfusion-transmitted Viruses Study in the 1970s were tested for the presence of antibody to hepatitis C virus (anti-HCV). Single specimens from five control subjects who did not receive transfusions tested negative for anti-HCV. Of four control subjects who did not receive transfusions and who developed non-A, non-B (NANB) hepatitis after hospitalization, three remained anti-HCV negative; the fourth person with postoperative NANB hepatitis tested anti-HCV positive before the operation. Five transfusion recipients with posttransfusion hepatitis B virus infection remained seronegative; a sixth with NANB hepatitis as well as hepatitis B virus infection had seroconversion for anti-HCV. Five of nine transfusion recipients with NANB hepatitis had anti-HCV seroconversion. These results show that present anti-HCV testing demonstrates an etiologic basis for approximately half of the cases of transfusion-associated NANB hepatitis, particularly those that develop chronicity. Although cases of NANB hepatitis without seroconversion may be explained otherwise, they may be caused by another, presently unidentified, virus.     

Self-poisoning and self-injury in the Oxford area. Epidemiological aspects 1969-73.

A prospective study of self-poisoning and self-injury in the Oxford area for 1972-73 and a retrospective study for 1969 has shown the following: (a) The number of admissions to a general hospital following self-poisoning and self-injury has increased by approximately 45% in 3 1/2 years. The increase is more marked in women than in men. (b) When compared with a previous study the incidence in Oxford city has quadrupled in ten years. (c) A total of 74% of men and 67% of women, aged 16 years and over, harming themselves in this way are under the age of 35 years. The repetitiveness is increasing and the proportion of those repeating the attempt was 10% within three months, and 15% within six months. (d) The rates are exceptionally high for teenage wives and single, widowed, and divorced women aged between 24-35 years. Single men show exceptionally high rates in the 35-45 year age group. (e) With the exception of married women aged between 25 and 34 years and women over 60, the rates were higher in urban than in rural areas. (f) In men the rates were higher among personal service workers, semi-skilled manual and unskilled manual workers. In women the rates were highest among non-manual, ancillary to professional (especially nurses), and semi-skilled manual workers. Male students had rates much lower than those of their age group, while female students had rates about the same as their age group. The lowest rates were among professional and 'own account' workers.     

Psychological and interpersonal correlates in men with erectile dysfunction and their partners: a pilot study of treatment outcome with sildenafil

The role of psychological and interpersonal factors in the treatment of erectile dysfunction (ED) with sildenafil or other oral therapies has not been sufficiently investigated. We conducted a pilot study of psychosocial predictors of pharmacotherapy treatment outcome and satisfaction in men with ED and their partners. Sixty-nine men with mild to moderate ED and their partners were enrolled in a multicenter, open-label, treatment trial with sildenafil. Treatment measures included a battery of validated self-report measures and questionnaires. Subjects also were interviewed according to a semistructured interview protocol. Partner assessments included self-report measures of sexual function, mood, and relationship satisfaction. Results indicated that, prior to treatment, patients had erectile function scores in the range of mild to moderate ED, with relatively low levels of concomitant depression, anxiety, and psychological stress and high overall levels of relationship adjustment. Partner sexual function was in the normal range of total Brief Index of Sexual Functioning for Women (BISF-W; Taylor, Rosen, Leiblum, 1994) scores, although more than one third of female partners had specific sexual complaints or problems. Among couples who completed one or both follow-up visits (N = 34), sildenafil treatment resulted in significant improvements in all aspects of sexual function in men, including sexual desire, orgasmic function, erectile function and overall sexual satisfaction. Significant improvements also were noted in partners' ratings of sexual function in most domains, including arousal, pleasure, and orgasm. Higher baseline levels of sex-specific anxiety were negatively associated with improvement in erections following treatment. Relationship adjustment at baseline, contrary to expectations, did not predict erectile or sexual satisfaction following treatment in the men or their partners but was significantly correlated with changes in sexual desire. Baseline levels of depression, anxiety, and stress generally were unrelated to efficacy or treatment satisfaction. However, we observed a curvilinear relationship in the men between baseline levels of stress and treatment discontinuation (i.e., subjects with moderate levels of stress were less likely to discontinue treatment). Because of a high number of dropouts, results of this pilot study await confirmation in a larger and more adequately powered clinical trial.     

Battered mothers speak out: participatory human rights documentation as a model for research and activism in the United States

This article describes the work of the Battered Mothers' Testimony Project, a multiyear effort that documented human rights violations against battered women and their children in the Massachusetts family court system. This article (a) presents the Battered Mothers' Testimony Project's participatory human rights methodology as an alternative model for research and activism on violence against women and children in the United States, (b) summarizes the authors' findings and human rights analysis of how the Massachusetts family courts handled custody and visitation in specified cases involving partner and child abuse, and (c) discusses U.S. obligations under international human rights law and the value of a human rights approach to violence against women and children in the United States.     

Ventricular function in idiopathic hypertrophic subaortic stenosis A ballistocardiographic and angiographic correlative study

Patients with idiopathic hypertrophic subaortic stenosis were studied by ballistocardiographic and angiographic techniques. A number of statistically significant differences were found between those with hypertrophic subaortic stenosis and normal subjects of similar age range. This ballistocardiographic study confirms findings of previous studies showing a greater early systolic contractile force in these patients with hypertrophic subaortic stenosis and more rapid acceleration of emptying. Correlation studies indicate that certain ballistocardiographic variables may quantitatively reflect ventricular function. Therefore, we have shown that relating ballistocardiographic measurements to dynamic variables may be useful in considering ventricular abnormality. It is strongly suggested that the relation of the ballistocardiogram to ventricular function is the major value inherent in the wave forms. Previous rejection of the ballistocardiogram as a useful clinical device or as an investigative technique appears to have been premature.