全文获取类型
收费全文 | 744篇 |
免费 | 36篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 14篇 |
妇产科学 | 85篇 |
基础医学 | 59篇 |
口腔科学 | 47篇 |
临床医学 | 72篇 |
内科学 | 153篇 |
皮肤病学 | 4篇 |
神经病学 | 35篇 |
特种医学 | 24篇 |
外科学 | 196篇 |
综合类 | 3篇 |
预防医学 | 9篇 |
眼科学 | 25篇 |
药学 | 24篇 |
中国医学 | 1篇 |
肿瘤学 | 16篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 2篇 |
2021年 | 19篇 |
2020年 | 20篇 |
2019年 | 24篇 |
2018年 | 35篇 |
2017年 | 26篇 |
2016年 | 28篇 |
2015年 | 31篇 |
2014年 | 23篇 |
2013年 | 48篇 |
2012年 | 47篇 |
2011年 | 66篇 |
2010年 | 38篇 |
2009年 | 31篇 |
2008年 | 38篇 |
2007年 | 48篇 |
2006年 | 64篇 |
2005年 | 46篇 |
2004年 | 46篇 |
2003年 | 33篇 |
2002年 | 16篇 |
2001年 | 9篇 |
2000年 | 8篇 |
1999年 | 7篇 |
1998年 | 3篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1985年 | 3篇 |
排序方式: 共有785条查询结果,搜索用时 31 毫秒
51.
Orhan Yilmaz Gulin Sunter Celal Salcini P?nar Kahraman Koytak Tulin Tanridag Onder Us Kayihan Uluc 《JOURNAL OF CLINICAL NEUROLOGY》2016,12(2):166-171
MethodsThe study investigated 60 hands of 35 patients with clinical CTS and 60 hands of 34 healthy controls. Routine median and ulnar nerve conduction studies and MUNE analysis according to the multipoint stimulation method were performed.ResultsThe most common electrophysiological abnormality was reduced conduction velocity in the median sensory nerve (100% of the hands). The MUNE value was significantly lower for the patient group than for the control group (p=0.0001). ROC analysis showed that a MUNE value of 121 was the optimal cutoff for differentiating between patients and controls, with a sensitivity of 63.3% and a specificity of 68.3%. MUNE values were lower in patients with complaints of numbness, pain, and weakness in the median nerve territory (p<0.05, for all comparisons), and lower in patients with hypoesthesia than in patients with normal neurological findings (p=0.023).ConclusionsThe MUNE technique is sensitive in detecting motor nerve involvement in CTS patients who present with sensorial findings, and it may be useful in detecting the loss of motor units during the early stages of CTS. Larger-scale prospective clinical trials assessing the effect of early intervention on the outcome of these patients would help in confirming the possible benefit of detecting subclinical motor-unit loss in CTS. 相似文献
52.
Mirac Baris Usta Ozgur Korhan Tuncel Seher Akbas Berna Aydin Gokce Nur Say 《Nordic journal of psychiatry》2016,70(2):116-120
Background: Recent evidence shows that the hypothalamic–pituitary–adrenal (HPA) axis can be dysregulated in chronic sexual abuse victims with post-traumatic stress disorder (PTSD). We hypothesized that PTSD in adolescents exposed to a single sexual trauma may function as a chronic stressor leading to HPA-axis dysregulation. Aims: The objective of this study was to assess dehydroepiandrosterone sulphate (DHEA-S) and cortisol levels in female adolescents |with single sexual trauma-related PTSD compared to healthy controls. Method: We assessed 20 female adolescent (age 12–18) single sexual trauma victims with PTSD from the Ondokuz Mayis University Department of Child and Adolescent Psychiatry between December 2013 and December 2014. PTSD symptoms were assessed using the Child Depression Inventory (CDI) and Child Posttraumatic Stress Reaction Index (CPSRI). Blood cortisol and DHEA-S were measured in 20 female adolescent sexual abuse victims with PTSD and 20 healthy adolescents after 12-h fasting using the chemiluminescence method. Results: Compared to age-matched controls, female adolescent sexual abuse victims with PTSD had significantly lower DHEA-S levels (U = 70.00, Z = ? 3.517, p = 0.01, r = 0.55). There was also a significant negative correlation between DHEA-S and CDI scores (Spearman r = ? 0.522, p < 0.01). Conclusions: Decreased DHEA-S levels and correlation with depressive symptoms are evidence for a dysregulated HPA-axis in female adolescent single sexual trauma victims with PTSD. Further research is now recommended with large patient groups in order to maximize generalizations. 相似文献
53.
PRAME mRNA levels in cases with acute leukemia: clinical importance and future prospects 总被引:9,自引:0,他引:9
Paydas S Tanriverdi K Yavuz S Disel U Baslamisli F Burgut R 《American journal of hematology》2005,79(4):257-261
The PRAME (preferentially expressed antigen of melanoma) gene has been shown to be expressed in high levels in some solid tumors and hemopoietic neoplasias but not or only weakly expressed in normal tissues. It encodes an antigen recognized by autologous cytolytic T lymphocytes. PRAME is a good candidate for tumor immunotherapy and is a useful marker gene for detection of minimal residual disease (MRD). In this study, PRAME mRNA using real-time RT-PCR was studied in 74 adult cases with acute leukemia-68 had de-novo acute leukemia, 3 had chronic myeloid leukemia-blastic crisis (CML-BC), and 3 had myelodysplastic/myeloproliferative syndrome-blastic transformation (MDS/MPD-BT)-and the results were compared with 30 age-matched healthy volunteers. Nineteen of 74 cases with leukemia expressed PRAME, while only 2 controls showed weak expression. The prevalence of PRAME expression in AML and ALL cases was 30% and 17%, respectively. We did not find any important correlation between PRAME expression and clinical characteristics, such as age, sex, organomegaly/lymphadenopathy, Hb, WBC count, platelet count, LDH level, alkaline phosphatase, albumin, cell-surface antigens, response to therapy, or progression-free and overall survival. PRAME was monitored in 15 cases during remission and/or relapse. There was a good correlation between PRAME mRNA and hematological remission and/or relapse. Interestingly, PRAME was very high in one case with AML but was not found 3 months after allogeneic transplantation. PRAME mRNA is observed in about one-third of AML cases; it may be a useful marker to detect MRD, and it may also be a good predictor for the timing of donor lymphocyte infusions (DLI) in the post-transplant period in cases of molecular relapse. 相似文献
54.
Effect of cardiac resynchronization therapy on left atrial reverse remodeling and spontaneous echo contrast 总被引:1,自引:0,他引:1
Vural A Ağaçdiken A Ural D Sahin T Kozdağ G Kahraman G Ural E Akbaş H Süzer K Komsuoğlu B 《The Tohoku journal of experimental medicine》2004,202(2):143-153
Recent studies revealed reverse remodeling in left ventricle with cardiac resynchronization therapy (CRT). However, effects on left atrial remodeling, left atrial total emptying fraction and left atrial spontaneous echo contrast (SEC) have not been adequately evaluated. The aim of this study was to investigate the long-term changes in SEC, left atrial reverse remodeling, and left atrial total emptying fraction after CRT. Twenty patients with systolic heart failure and complete left bundle-branch block underwent implantation of biventricular pacemaker devices. Transthoracic and transesophageal echocardiography were performed one week before and one and six months after pacemaker implantation. After biventricular pacemaker implantation, significant clinical improvement was observed in all patients. Left atrial maximal and minimal volumes showed a significant progressive decline after CRT (reverse remodeling). Left atrial total emptying ejection fraction (LATEF) was 33 +/- 19% at baseline and increased to 37 +/- 10% and 41 +/- 11% at the 1st and 6th months respectively (p = 0.01 and p = 0.04). SEC was detected in 18 of 20 patients (90%) at the beginning of the study. After six months SEC disappeared in 5 patients and frequency of SEC reduced to 45%. Decrease in the intensity of the SEC was also statistically significant (at the 1st and 6th months; p = 0.001 and p < 0.001 respectively). Long-term CRT results in atrial reverse remodeling, increases LATEF, and reduces both frequency and intensity of atrial SEC. 相似文献
55.
Altinbas A Ozaydin M Kahraman H Dogan A 《The international journal of cardiovascular imaging》2003,19(3):185-187
Coarctation of the aorta is one of the congenital heart diseases diagnosed primarily in childhood and early adolescence. A 67-year-old female was admitted to the hospital with chest pain. Angiography revealed a coarctation of the aorta, coronary ectasia and dilatation of the ascending aorta. This case attracted our attention because the first diagnosis was made at such an advanced age and coarctation was accompanied by coronary ectasia and dilatation of the ascending aorta. Therefore, we decided to report the case. 相似文献
56.
57.
Basyigit I Kahraman G Ilgazli A Yildiz F Boyaci H 《American journal of therapeutics》2005,12(5):407-410
In this study, our aim was to investigate the proarrhythmic effects of levofloxacin. Twenty-six patients who were diagnosed as having community-acquired pneumonia were enrolled in the study. Intravenous levofloxacin, 500 mg daily, was given, and 12-lead ECG measurements were obtained before the infusion, at 30 and 60 minutes during infusion, and 10 minutes after its cessation. Resting late potentials were recorded before and after infusion. Twelve female and 14 male patients were participated the study. Mean age was 51.3 +/- 22.3 years. Levofloxacin infusion increased the heart rate (HR) and prolonged the corrected QT (QTc) intervals significantly (baseline HR: 84.6 +/- 18.8 vs. HR at 60 minutes: 88.6 +/- 18, P = 0.02; baseline QTc: 413.5 +/- 36.9 milliseconds vs. QTc at 60 minutes: 426.1 +/- 34.7, P = 0,006). There was no significant difference between the late potential values obtained before and after infusion. None of our patients experienced severe arrhythmia that required stopping the treatment. A single dose of IV levofloxacin prolongs the QTc interval without significant change in late potentials. Monitoring ECG during levofloxacin infusion might be necessary in patients who have a condition that could affect the QTc interval. 相似文献
58.
Guzin Gonullu Hakkı Kahraman Abdulkerim Bedir Ahmet Bektas Idris Yücel 《International journal of colorectal disease》2010,25(2):205-212
Purpose
In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance. 相似文献59.
We investigated whether a proximal femoral nail (PFN) having two lag screws can be implanted without distal locking screws
in AO/OTA 31-A1 and 31-A2 intertrochanteric femur fractures. Twenty-four patients with AO/OTA 31-A1 and 31-A2 fractures were
treated with a PFN without distal interlocking by a single surgeon. The mean follow-up was 12 months (range: 7–23). Clinical
and functional outcome was assessed according to the Harris hip score and Barthel’s activity score. The fractures healed in
all patients; the average consolidation time was 14 weeks (range: 9–28). Fourteen patients had excellent and good results,
nine patients had fair results, and one patient had a poor result according to the Harris hip score; 17 patients had a high
range of mobility according to the Barthel activity score. Our results suggested that the PFN can be successfully implanted
without distal interlocking in 31-A1 and 31-A2 fractures. 相似文献
60.
Korhan Taviloglu MD FACS Hakan Yanar 《European journal of trauma and emergency surgery》2009,35(2):90-94
Abstract
The management of patients with solid organ injuries has changed since the introduction of technically advanced imaging tools,
such as ultrasonography and multiple scan computerized tomography, interventional radiological techniques and modern intensive
care units. In spite of this development in the management of these patients, major solid organ traumas can still be challenging.
There has been great improvement in the non-operative management (NOM) of intra-abdominal solid organ injury in recent decades.
In most cases treatment of injuries has shifted from early surgical treatment to NOM. 相似文献