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91.
Z A Arlin T Ahmed A Mittelman E Feldman R Mehta P Weinstein E Rieber P Sullivan P Baskind 《Journal of clinical oncology》1987,5(3):371-375
Amsacrine and high-dose cytarabine (HiDAc), when administered as single agents, are effective treatment of acute leukemia. When used in combination, a high remission rate is also possible. We treated 47 patients with acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), and blastic phase of chronic myelogenous leukemia (CML) with a combination of amsacrine and HiDAc. The patients received amsacrine 200 mg/m2 daily for three days and, concurrently, HiDAc 3 g/m2 over three hours once daily for five days. Of 20 evaluable patients with AML in relapse, there were 12 remissions; of seven additional patients with primary refractory AML, there were two remissions, and of 12 patients with ALL in relapse, there were eight remissions. The three patients with blastic phase CML and the three patients with biphenotypic leukemia did not respond. Nausea, vomiting, stomatitis, hepatic dysfunction, and diarrhea were common, but cutaneous, conjunctival, and significant cerebellar and cerebral side effects were absent. We conclude that this regimen is highly effective therapy for AML and ALL and is also safe, eliminating the major toxicities encountered with HiDAc. 相似文献
92.
Mansour Njah Radhia Hergli Jalel Gloulou Slim Ben Ahmed et Moncef Marzouki 《Sozial- und Pr?ventivmedizin》1994,39(5):280-286
Resumé Dans le but d'analyser les besoins d'une population en matière de dépistage des cancers, les attitudes, connaissances et comportements des femmes à propos des cancers du sein et du col utérin sont étudiées, auprès d'un groupe de consultantes tout venant de 3 centres de santé tunisiens (Kalaa-Kebira). Les résultats soulignent la nécessité d'informer la population concernant les facteurs de risque de ces maladies, particulièrement en ce qui concerne le cancer du sein, (1er cancer de la femme en Tunisie) mais surtout sur les signes d'appel et les moyens de dépistage disponibles. Le rôle des professionnels de la santé, plus du généraliste et de la sage-femme que du gynécologue apparait clair auprès des consultantes. L'éducation individuelle et de masse doit cependant aller de pair avec une sensibilisation et une formation des professionnels de la santé eux-mêmes en matière de dépistage.
Knowledges, attitudes and behaviors of Tunisian women about gynaecologic cancers
Summary With the aim to analyze population needs in the field of cancer screening (cervical and breast cancer), attitudes, behaviors and knowledge of a tunisien women group of health service user's were studied. Results clearly demonstrate the necessity to inform the concerned population about risk factors particularly concerning breast cancer (the most frequent cancer in Tunisia) but also early symptoms and available screening methods. This role is alloted to health professionals, more for general practitioners and midwives than for gynaecologists. Health education for women and groups, however, have to go hand in hand with training of health professionals in matter of test screening.
Kenntnisse, Haltung und Verhalten der tunesischen Frauen in Bezug auf gynäkologische Krebse
Zusammenfassung Haltung, Kenntnisse und Verhalten der Frauen gegenüber dem Brustkrebs und dem des Uterushalses wurden an Hand einer Patientinnengruppe in Tunesischen Gesundheitszentren (Kalaa-kebira) erlangt. Die Ergebnisse bestätigen die Notwendigkeit, die Bevölkerung über die Risikofaktoren dieser Krankheiten zu unterrichten, besonders was den Brustkrebs betrifft (den verbreitetsten Krebs bei Frauen in Tunesien), aber vor allem über die Krankheitsanzeichen und die verfügbaren diagnosemethoden. Die Rolle der Gesundheitskräfte, insbesondere die des Allgemeinarztes und der Hebamme, noch vor derjenigen des Frauenarztes, sind den Patientinnen verständlich. Die individuelle sowie die massenhafte Gesundheitserziehung muss Hand in Hand gehen mit einer Sensibilisierung und einer Ausbildung des Gesundheitspersonals in Sachen Diagnosemethoden.相似文献
93.
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95.
The effects on rats of intermittent feeding with the peroxisome proliferator and hepatocarcinogen di(2-ethylhexyl) phthalate (DEHP) have been examined. Male Wistar rats were fed for alternate 7-day periods diets containing 20,000 ppm DEHP or the control diet. The rats were examined 3 days after the start or recommencement of administration of the DEHP-containing diet or after 7 days on the control diet. After the commencement or recommencement of feeding with DEHP the expected increases in liver weight and in the number of peroxisomes were found. The increase in liver: body-weight ratio in response to administration of DEHP-containing diets was greater in rats that had been previously exposed to the compound, but re-administration of DEHP had a less marked effect on the increase in peroxisome number. Morphometric analysis showed that administration of DEHP-containing diets resulted in an increase in cell number in the liver and that a fall in the cell number occurred after the rats had been returned to the control diet for 7 days. Analysis of nuclear size gave results consistent with an increase in tetraploid hepatocytes after treatment with DEHP which was reversed when the rats were returned to control diet. 相似文献
96.
Leonardo A Sechi Giovanna E Felis Niyaz Ahmed Daniela Paccagnini Donatella Usai Silvia Ortu Paola Molicotti Stefania Zanetti 《Infection, genetics and evolution》2007,7(4):424-432
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (JD), a chronic gastroenteritis of ruminants and other animals, including primates. Many evidences suggested association of MAP to Crohn's disease, a chronic granulomatous gastrointestinal disease of humans with strong similarities with JD. The present study attempts to evaluate global gene regulation in MAP, which has not been addressed previously, despite the availability of MAP genome sequence. For this purpose, we investigated: (i) the presence of sigma factors and their relationship to sigma factors of other mycobacteria (M. avium subsp.avium, M. tuberculosis, M. bovis, M. leprae and M. smegmatis), and (ii) their expression during different growth conditions and in vitro infection of intestinal epithelial Caco2 cells. MAP genome contains 19 putative sigma factor, but only 12 belong to gene families common to other mycobacteria. Gene expression was evaluated with Real-Time PCR during growth in 7H9 medium and mycobactin J, in 7H9 medium plus mycobactin J and lisozyme, and during infection of Caco2 cells: very different expression patterns were observed and, on the whole, only 7 sigma factors were found to be expressed. sigJ was upregulated during the infection of Caco2 cells. Even if only few sigma factors were expressed in the three conditions tested, the overall high numbers of MAP sigma factors suggests a noteworthy flexibility of this pathogen. Thus, this first report on expression of MAP sigma factors opens the way to an extensive characterization of global gene regulation, as a key to understand strategies of survival and mechanisms of infections used by this organism. 相似文献
97.
98.
Abuzeid MI Mitwally MF Ahmed AI Formentini E Ashraf M Abuzeid OM Diamond MP 《Journal of minimally invasive gynecology》2007,14(1):49-53
STUDY OBJECTIVE: The presence of fimbrial pathology in advanced endometriosis is clearly understood. However, little is known about the prevalence of fimbrial pathology in early stages of endometriosis. The purpose of this study is to determine the prevalence of fimbrial pathology in patients with infertility with early stages of endometriosis. DESIGN: Historical cohort study (Canadian Task Force classification II/III). SETTING: Tertiary referral center. PATIENTS: The study group (Group 1) consisted of 315 infertile women who were found to have stage I or stage II endometriosis, and the control group (Group 2) consisted of 152 infertile women without endometriosis (Group 2). INTERVENTION: Laparoscopic evaluation for the presence and type of fimbrial pathology. MEASUREMENTS AND MAIN RESULTS: The prevalence of fimbrial pathology was significantly higher in infertile patients with early stages of endometriosis (50.2%) compared with infertile patients with no endometriosis (17.8%, p <.0001). CONCLUSION: These preliminary data suggest the presence of fimbrial pathology in many patients with early stages of endometriosis. Such pathology may act as a mechanical factor interfering with the ovum pick-up mechanism. 相似文献
99.
Background : Bladder augmentation may be undertaken by using various gastrointestinal segments but their use is associated with a multitude of well-recognized complications. The mega-ureter has proven to be a satisfactory alternative; in patients with bilateral mega-ureters, both ureters may be used for this purpose. Methods : Seventeen patients had augmentation ureterocystoplasty, including three in whom both distal ureters were used in tandem. The latter included two patients with neurogenic bladder and one with bladder exstrophy. Results : Satisfactory augmentation was achieved in all patients undergoing tandem ureterocystoplasty. The neurogenic bladder patients are managed by urethral clean intermittent catheterization (CIC) and the exstrophy patient is managed by CIC of an appendico-vesicostomy (Mitrofanoff). All are continent. Conclusions : The mega-ureter provides an excellent source of augmentation material in patients with small non-compliant bladders. In those with bilateral mega-ureters, consideration should be given to using both ureters in tandem to achieve the maximum possible bladder capacity. 相似文献
100.