全文获取类型
收费全文 | 476篇 |
免费 | 6篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 8篇 |
妇产科学 | 1篇 |
基础医学 | 65篇 |
口腔科学 | 5篇 |
临床医学 | 51篇 |
内科学 | 61篇 |
神经病学 | 40篇 |
特种医学 | 2篇 |
外科学 | 37篇 |
综合类 | 51篇 |
预防医学 | 6篇 |
眼科学 | 4篇 |
药学 | 146篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 1篇 |
出版年
2022年 | 7篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2015年 | 4篇 |
2014年 | 17篇 |
2013年 | 20篇 |
2012年 | 12篇 |
2011年 | 21篇 |
2010年 | 10篇 |
2009年 | 13篇 |
2008年 | 13篇 |
2007年 | 19篇 |
2006年 | 19篇 |
2005年 | 10篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 10篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 11篇 |
1995年 | 14篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 17篇 |
1991年 | 14篇 |
1990年 | 14篇 |
1989年 | 12篇 |
1988年 | 20篇 |
1987年 | 8篇 |
1986年 | 11篇 |
1985年 | 6篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 3篇 |
1980年 | 9篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 10篇 |
1975年 | 5篇 |
1974年 | 8篇 |
1973年 | 8篇 |
1971年 | 4篇 |
1970年 | 2篇 |
排序方式: 共有486条查询结果,搜索用时 15 毫秒
1.
2.
3.
Daniel E. Mckee Donald H. Lalonde Achilleas Thoma Lisa Dickson 《Hand (New York, N.Y.)》2015,10(4):613-615
Background
In our experience, for all surgeries in the hand, the optimal epinephrine effect from local anesthesia—producing maximal vasoconstriction and visualization—is achieved by waiting significantly longer than the traditionally quoted 7 min from the time of injection.Methods
In this prospective comparative study, healthy patients undergoing unilateral carpal tunnel surgery waited either 7 min or roughly 30 min, between the time of injection of 1 % lidocaine with 1:100,000 epinephrine and the time of incision. A standardized incision was made through dermis and into the subcutaneous tissue followed by exactly 60 s of measuring the quantity of blood loss using sterile micropipettes.Results
There was a statistically significant reduction in the mean quantity of bleeding in the group that waited roughly 30 min after injection and before incision compared to the group that waited only 7 min (95 % confidence intervals of 0.06 + −0.03 ml/cm of incision, compared to 0.17 + −0.08 ml/cm, respectively) (P = 0.03).Conclusions
Waiting roughly 30 min after injection of local anesthesia with epinephrine as oppose to the traditionally taught 7 min, achieves an optimal epinephrine effect and vasoconstriction. In the hand, this will result in roughly a threefold reduction in bleeding—making wide awake local anesthesia without tourniquet (WALANT) possible. This knowledge has allowed our team to expand the hand procedures that we can offer using WALANT. The benefits of WALANT hand surgery include reduced cost and waste, improved patient safety, and the ability to perform active intraoperative movement examinations. 相似文献4.
P Kalra AS Rana RK Peravali D Gupta G Jain 《Journal of maxillofacial and oral surgery》2011,10(3):230-235
Background
Lignocaine hydrochloride is the most widely used and easily available local anaesthetic agent. Adrenaline is frequently combined with lignocaine to enhance the duration of anaesthesia, decrease toxicity, to achieve vasoconstriction and to provide a bloodless field. 相似文献5.
Anaphylaxis is an acutely presenting life‐threatening medical emergency. Surveys indicate that dentists feel inadequately able to recognize and treat anaphylaxis. This paper reviews the terminology and pathophysiology of anaphylaxis, and describes the recognition and initial management of anaphylaxis for dentists. Dentists should be able to administer intramuscular adrenaline during anaphylaxis at the appropriate dose. The role of further medical care is also explained. Six cases of anaphylaxis arising from dental oral maxillofacial surgery practice are discussed. 相似文献
6.
蒋丽娅 《中国继续医学教育》2015,(18)
目的:探析阿替卡因联合肾上腺素治疗牙髓病的临床效果。方法选择2014年2月~2015年1月期间我院收治的牙髓病患者66例为研究对象,随机分为两组,其中给予对照组常规治疗,而观察组则运用阿替卡因与肾上腺素联合治疗,对比分析两组的治疗效果。结果两组均顺利完成治疗,观察组的麻醉起效时间为(133±22)s;而对照组的麻醉起效时间为(187±32)s,并且观察组的麻醉总有效率优于对照组,组间对比差异有统计学意义(P<0.05)。结论临床上将阿替卡因和肾上腺素联合运用在牙髓病的治疗中,不仅起效快、安全性高,在一定程度上还能提高麻醉效果,确保手术的顺利进行。 相似文献
7.
8.
《Seminars in Fetal & Neonatal Medicine》2018,23(5):355-360
The majority of newborn resuscitations require very little beyond simple airway management and assisted ventilation. If cardiovascular collapse is serious enough to warrant additional support, resuscitation algorithms recommend moving to chest compressions and then on to medications and possibly volume replacement if vital signs remain marginal or absent. The evidence base upon which this part of the neonatal resuscitation algorithm is structured is sparse. Chest compressions and medications are rare interventions that do not lend themselves easily to clinical trials. Slowly but surely, however, the genesis of an empirical evidence base for this part of the algorithm is beginning to appear. 相似文献
9.
Basal and exercise-induced neuroendocrine activation in patients with heart failure and in normal subjects 总被引:3,自引:0,他引:3
BACKGROUND: Neuroendocrine activation is a pathophysiological response and an important prognostic marker in patients with chronic heart failure (CHF). Although chronic activation is well described, data on the responsiveness of the hormone systems are more limited. Most previous studies have looked at activation during maximal exercise, whereas we believe that activation at a submaximal level might be more pathophysiologically relevant. AIM: To compare exercise-induced neurohormonal activation between CHF patients and normal subjects using the same relative and submaximal workload. Subjects: Twenty-three newly-diagnosed CHF patients and 18 age- and gender-matched healthy subjects were exercised at two workloads, which were calculated to correspond to 50 and 75% of each individual's heart rate response. RESULTS: In CHF patients, baseline levels of ANP, BNP, AVP, PRA and ET-1 were elevated compared to healthy subjects. Exercise induced an increase in ANP, A and NA in both CHF patients and in normal subjects, however BNP was only increased in CHF patients and not in normal subjects. CONCLUSION: When CHF patients exercise at the same relative and submaximal level as age-matched healthy subjects, the relative increases in ANP, A and NA were similar, however, BNP levels only increased in the CHF group. 相似文献
10.
Hypoglycaemia unawareness in type 1 diabetes: a lower plasma glucose is required to stimulate sympatho-adrenal activation. 总被引:1,自引:0,他引:1
To investigate the relationship between awareness of symptoms and the autonomic reaction of hypoglycaemia, acute hypoglycaemia was induced with intravenous insulin (2.5 mU kg-1 min-1) in diabetic and non-diabetic subjects, all of whom had normal cardiovascular autonomic function tests. Three groups were studied: (1) nine patients with Type 1 diabetes with loss of awareness of hypoglycaemia; (2) eight patients who had normal awareness of hypoglycemia, matched for duration of diabetes and blood glucose control; (3) eleven non-diabetic volunteers. The onset of the acute autonomic reaction was identified objectively by the sudden and rapid responses of heart rate and sweating. Cognitive function and hypoglycaemia symptom scores were estimated serially. Acute autonomic activation was observed to occur in all subjects in response to hypoglycaemia. In the 'unaware' diabetic patients, onset of the reaction occurred at a significantly lower plasma glucose (1.0 +/- 0.1 mmol l-1) than in the 'aware' diabetic patients (1.6 +/- 0.2 mmol l-1) (p less than 0.05) or in the non-diabetic control group (1.4 +/- 0.1 mmol l-1) (p less than 0.05). Obvious neuroglycopenia was observed only in the 'unaware' diabetic group and developed when plasma glucose had declined to approximately 1.4 +/- 0.1 mmol l-1, and thus preceded the reaction (p less than 0.02 vs the autonomic threshold). The maximal rise in plasma adrenaline was of similar magnitude in all three groups but a lower plasma glucose was required to stimulate this hormonal response in the 'unaware' patients, in whom the plasma adrenaline concentration was lower at the time of the reaction. Thus, the plasma glucose at which activation of the autonomic reaction was observed was lower in the diabetic patients with unawareness of hypoglycaemia. 相似文献