To assess test–retest stability of four functional magnetic resonance imaging (fMRI)‐derived resting brain activity metrics: the seed‐region‐based functional connectivity (SRFC), independent component analysis (ICA)‐derived network‐based FC (NTFC), regional homogeneity (ReHo), and the amplitude of low frequency fluctuation (ALFF).
Methods:
Simulations were used to assess the sensitivity of SRFC, ReHo, and ALFF to noise interference. Repeat resting blood oxygen level‐dependent (BOLD) fMRI were acquired from 32 healthy subjects. The intraclass correlation coefficient (ICC) was used to assess the stability of the four metrics.
Results:
Random noise yielded small random SRFC, small but consistent ReHo and ALFF. A neighborhood size greater than 20 voxels should be used for calculating ReHo in order to reduce the noise interference. Both the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC)‐based SRFC were reproducible in more spatially extended regions than ICA NTFC. The two regional spontaneous brain activity (SBA) measures, ReHo and ALFF, showed test–retest reproducibility in almost the whole gray matter.
Little is known about how spontaneous brain activity during the resting state may be altered in posttraumatic stress disorder (PTSD) compared to traumatized individuals. In the current study, we used a measure of amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the regional baseline brain function of this disorder. Fifty-four medication-naive PTSD patients and seventy-two matched traumatized comparison subjects who experienced the Sichuan major earthquake participated in a functional magnetic resonance imaging (fMRI) scan. We analyzed the difference between the PTSD and comparison groups during a resting state using ALFF. PTSD patients showed decreased ALFF values in right lingual gyrus, cuneus, middle occipital gyrus, insula, and cerebellum, and increased ALFF values in right medial and middle frontal gyri, relative to traumatized individuals without PTSD. The ALFF value in the right medial frontal gyrus was positively correlated with severity of the disorder. Our findings show that abnormality of intrinsic brain activity exists under resting conditions in PTSD patients exposed to a major earthquake. Altered ALFF in predominantly right hemisphere cortical and subcortical regions and in cerebellum potentially contribute to the neural mechanisms underlying traumatic memory and symptoms in PTSD. 相似文献
Resting‐state functional magnetic resonance imaging (rs‐fMRI) offers the possibility to assess brain function independent of explicit tasks and individual performance. This absence of explicit stimuli in rs‐fMRI makes analyses more susceptible to nonneural signal fluctuations than task‐based fMRI. Data preprocessing is a critical procedure to minimise contamination by artefacts related to motion and physiology. We herein investigate the effects of different preprocessing strategies on the amplitude of low‐frequency fluctuations (ALFFs) and its fractional counterpart, fractional ALFF (fALFF). Sixteen artefact reduction schemes based on nuisance regression are applied to data from 82 subjects acquired at 1.5 T, 30 subjects at 3 T, and 23 subjects at 7 T, respectively. In addition, we examine test–retest variance and effects of bias correction. In total, 569 data sets are included in this study. Our results show that full artefact reduction reduced test–retest variance by up to 50%. Polynomial detrending of rs‐fMRI data has a positive effect on group‐level t‐values for ALFF but, importantly, a negative effect for fALFF. We show that the normalisation process intrinsic to fALFF calculation causes the observed reduction and introduce a novel measure for low‐frequency fluctuations denoted as high‐frequency ALFF (hfALFF). We demonstrate that hfALFF values are not affected by the negative detrending effects seen in fALFF data. Still, highest grey matter (GM) group‐level t‐values were obtained for fALFF data without detrending, even when compared to an exploratory detrending approach based on autocorrelation measures. From our results, we recommend the use of full nuisance regression including polynomial detrending in ALFF data, but to refrain from using polynomial detrending in fALFF data. Such optimised preprocessing increases GM group‐level t‐values by up to 60%. 相似文献
Internet addiction refers to problematic patterns of internet use that continually alter the neural organization and brain networks that control impulsive behaviors and inhibitory functions. Individuals with elevated tendencies to develop internet addiction represent the transition between healthy and clinical conditions and may progress to behavioral addictive disorders. In this network neuroscience study, we used resting‐state functional magnetic resonance imaging (rs‐fMRI) to examine how and whether individual variations in the tendency of developing internet addiction rewire functional connectivity and diminish the amplitude of spontaneous low‐frequency fluctuations in healthy brains. The influence of neurocognitive aging (aged over 60 years) on executive‐cerebellar networks responsible for internet addictive behavior was also investigated. Our results revealed that individuals with an elevated tendency of developing internet addiction had disrupted executive‐cerebellar networks but increased occipital‐putamen connectivity, probably resulting from addiction‐sensitive cognitive control processes and bottom‐up sensory plasticity. Neurocognitive aging alleviated the effects of reduced mechanisms of prefrontal and cerebellar connectivity, suggesting age‐related modulation of addiction‐associated brain networks in response to compulsive internet use. Our findings highlight age‐related and individual differences in altered functional connectivity and the brain networks of individuals at a high risk of developing internet addictive disorders. These results offer novel network‐based preclinical markers of internet addictive behaviors for individuals of different ages. 相似文献
Objective: The targets of this study were to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance.
Methods: A total of 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning. We applied the ALFF method to detect the spontaneous brain activity. Receiver operating characteristic (ROC) curve was applied to distinguish RD Patients from HCs.
Results: RD patients showed decreased ALFF values in the right occipital lobe and right medial frontal gyrus and increased ALFF values in the right frontal superior orbital and left inferior temporal gyrus when compared with HCs. In RD patients, we did not find any relationship between the mean ALFF values and the clinical behavioral performances.
Conclusion: The RD patients exhibited abnormal spontaneous brain activity in vision and vision related brain regions, which might explore potential pathological mechanism of acute vision loss in RD patients. 相似文献