Heart rupture as an acute complication of cocaine abuse: A case report

The purpose of this study is to show a very rare complication of acute cocaine poisoning, namely heart rupture. In the present case report, acute cocaine intoxication caused massive myocardial infarction, resulting in heart rupture and cardiac tamponade. A crime scene investigation found a dead body on the street in a drug dealing district. Examination of the body showed no external injuries. A thorough autopsy was performed showing massive cardiac tamponade with 510 ml of blood within the pericardium and full-thickness tissue lesion at the posterior wall of the left ventricle of 3.5 × 3 cm. Histological examination in hematoxylin and eosin was performed and confirmed the interruption of the posterior wall of the left ventricle with the presence of blood. In fact, although the correlation between cocaine and myocardial damage is well established, the relationship between heart rupture and acute cocaine intoxication is an extremely rare event. Moreover, since there are, to date, few reports of similar deaths, our report provides useful information regarding sudden death in a cocaine abuser. It is, therefore, of crucial importance to report this case to the scientific community.     

胎膜早破孕妇生殖道感染情况及对妊娠结局影响

目的 研究胎膜早破孕妇生殖道感染情况及对妊娠结局的影响。方法 选择2014年5月至2015年1月住院分娩的胎膜早破孕妇70例为早破组,同期无胎膜早破70例为对照组,检测两组生殖道病原微生物感染情况,并比较两组的妊娠结局。结果 早破组生殖道感染阳性率高于对照组,且剖宫产率,母体发生产后出血,绒毛膜羊膜炎,胎儿窘迫及新生儿窒息发生率均高于对照组,差异均有统计学意义(P<0.05)。结论 生殖道感染是胎膜早破最常见的诱因,积极筛查及治疗孕妇生殖道感染可以减少相关产科并发症的发生。     

脾保留手术治疗创伤性脾破裂的临床探讨

目的：分析脾保留手术治疗创伤性脾破裂的疗效。方法选取该院2011年6月—2014年6月收治的创伤性脾破裂患者，共计56例，分为两组，各28例，对照组进行脾切除手术，研究组进行脾保留手术。结果研究组临床有效率为92.86%，对照组临床有效率为78.57%；术后并发症发生率研究组为10.71%、对照组为28.57%。结论脾保留手术治疗创伤性脾破裂的疗效显著，恢复快，并发症少，在患者伤情允许情况下优先选择脾保留术。     

急诊肝动脉栓塞治疗原发性肝癌破裂出血

目的评价肝动脉栓塞（TAE）在原发性肝癌自发性破裂出血治疗中的作用。资料与方法采用Seldinger技术，使用碘化油、明胶海绵作为栓塞剂，对12例肝癌破裂出血患者行TAE。结果12例行TAE后出血均得到完全控制．所有病例均无复发出血及急性肝功能衰竭。1例术后10天获二期外科手术切除，11例定期再行1～4次肝动脉化疗栓塞（TACE）治疗，1年存活率为27．3％。结论TAE是原发性肝癌破裂急诊止血的安全、有效方法。     

A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease,seizures and cotton wool plaques,but not spastic paraparesis

Over 100 mutations in the presenilin‐1 gene (PSEN1) have been shown to result in familial early onset Alzheimer disease (EOAD), but only a relatively few give rise to plaques with an appearance like cotton wool (CWP) and/or spastic paraparesis (SP). A family with EOAD, seizures and CWP was investigated by neuropathological study and DNA sequencing of the PSEN1 gene. Aβ was identified in leptomeningeal vessels and in cerebral plaques. A single point mutation, p.L420R (g.1508T > G) that gives rise to a missense mutation in the eighth transmembrane (TM8) domain of PS1 was identified in two affected members of the family. p.L420R (g.1508T > G) is the mutation responsible for EOAD, seizures and CWP without SP in this family.     

脾修补治疗脾破裂84例报告

目的 :探讨外伤性脾破裂行脾修补术的适应证及具体术式的选择。方法 :对 84例外伤性脾破裂行脾修补术的临床资料进行分析总结。结果 :84例中 ,死亡 1例 (死于颅脑损伤 ,尸检显示修补之脾脏创口缝线牢实 ,大网膜黏附良好 ,腹腔无术后陈旧性积血 ) ,死亡率 1.19% ;治愈 83例 ,治愈率 98.81%。结论 :综合生命体征指标和脾脏受损程度等多种因素 ,对 ～ 级的外伤性脾破裂可以施行脾修补术。根据不同情况选择相应的术式 ,修补时应充分利用大网膜 ,不宜剥掉创口中已形成的牢固血凝块     

脾部分切除术治疗创伤性脾破裂21例临床分析

目的：探讨脾保留性手术在临床中的应用。方法：对21例病人施行了原脾1／3、2／3体积保留性手术，其中脾部分切除术12例，脾胃韧带保留6例，脾膈韧带保留1例，脾结肠韧带保留2例，均为男性病人，年龄18－47岁，平均年龄26岁。结果：全组病例治愈出院，随访3个月－1年，血常规、血小板计数均在正常范围，B超、CT、脾窝内切可见大小不等的正常脾脏组织图像明显增大，可保留原位脾脏的解剖部位符合人体生理机理。结论：脾保留性手术在外伤性碑破裂中应用安全、可行，值得推广。