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排序方式: 共有884条查询结果,搜索用时 15 毫秒
1.
Kamran Sardari 《Comparative clinical pathology》2007,16(2):97-102
Local injection of a mixture of beta-aminopropionitril fumarate (BAPN-f) and sodium hyaluronate (NaH+) together with controlled exercise were evaluated for treatment of superficial digital flexor tendon (SDFT) injuries in horses.
Fourteen mixed breed horses with subacute SDF tendon injuries in forelimbs were randomly assigned to two groups. One group
received BAPN-f (0.7 mg/ml) and the other received NaH+ (10 mg/ml) all by intratendinous injection. Controlled exercise started during the first week after intratendinous treatment
and continued for 12 weeks. Cross-sectional area (CSA) of the SDFT, diameter of the SDFT, and relative area of the lesion
(presence of CSA) were measured by ultrasonographic examination. Lesions were semiquantitatively graded for echogenicity on
a scale of 0 to 4. The lesion severity in CSA was significantly reduced by BAPN and NaH compared to those horses treated by
BAPN only (p < 0.05). Lesion echogenicity score was significantly higher in horses treated with BAPN and NaH+ at day 0 compared to horses treated with BAPN (p < 0.05). At the end of the study, lesion echogenicity score was significantly reduced in the horses treated with BAPN and
NaH+ compared to horses treated by BAPN only (p < 0.05). According to the results of the present study, a combination of BAPN-f and NaH+ has a greater beneficial effect on tendon healing and remodeling in horses, as assessed by sonographic examination, compared
to treatment with single drugs. 相似文献
2.
Chen M Bennedsen M Zhai L Kharazmi A 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2001,109(12):801-808
A 65 kD membrane-associated NADH-fumarate reductase subunit, which has a molecular weight similar to that of one of the enzyme subunits from bacteria, was purified from Leishmania donovani promastigotes. NADH-fumarate reductase and other mitochondrial enzymatic activities of L. major and L. donovani promastigotes and amastigotes were investigated. The presence of NADH-fumarate reductase was demonstrated in digitonin-permeabilized L. major promastigotes and mitochondria of L. major and L. donovani promastigotes and amastigotes. The activity of solubilized NADH-fumarate reductase was measured in L. major and L. donovani promastigotes. Succinate exhibited a clear concentration-dependent inhibitory effect on fumarate reductase, whereas fumarate also exhibited a clear concentration-dependent inhibitory effect on succinate dehydrogenase. The data indicate that fumarate reductase is an obligatory component of the respiratory chain of the parasite. Since the enzyme is an important component in the intermediate metabolism in the Leishmania parasite and is absent in mammalian cells, it could be a potential target for antileishmanial drugs. 相似文献
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Alessia Cimadamore Liang Cheng Marina Scarpelli Francesco Massari Veronica Mollica Matteo Santoni Antonio Lopez-Beltran Rodolfo Montironi Holger Moch 《Translational andrology and urology》2021,10(3):1506
In 1952, renal cell carcinomas had been divided into 2 categories—clear cell or granular cell—depending upon their cytoplasmic staining characteristics. In the following years, the inventory of renal epithelial tumors has expanded by the addition of tumors named by their architectural pattern (i.e., papillary RCC, tubulocystic RCC), anatomic location (i.e., collecting duct carcinoma, renal medullary carcinoma), associated diseases (i.e., acquired cystic disease-associated RCCs). With the extensive application of molecular diagnostic techniques, it becomes possible to detect genetic distinctions between various types of renal neoplasm and discover new entities, otherwise misdiagnosed or diagnosed as unclassified RCC. Some tumors such as ALK rearrangement-associated RCC, MiT family translocation renal carcinomas, SDH-deficient renal cancer or FH-deficient RCC, are defined by their molecular characteristics. The most recent World Health Organization (WHO) classification of renal neoplasms account for more than 50 entities and provisional entities. New entities might be included in the upcoming WHO classification. The aim of this review is to summarise and discuss the newly acquired data and evidence on the clinical, pathological, molecular features and on the prognosis of new RCC entities, which will hopefully increase the awareness and the acceptance of these entities among clinicians and improve prognostication for individual patients. 相似文献
5.
C. de Mey K. Beithaupt D. Palm U. Fuhr G. G. Belz 《European journal of clinical pharmacology》1993,44(4):341-348
Summary The cardiovascular effects at rest and during exercise and 1- and 2-adrenoceptor occupancy following a single dose of 1200 mg celiprolol p. o. were investigated in 8 healthy subjects with or without pretreatment with a single dose of 20 mg bisoprolol p. o., using a place-bo-controlled, 2-way cross-over design.The ergometric responses of heart rate (HR) and systolic blood pressure (SBP) after celiprolol were reduced to a similar extent as after bisoprolol, but the cardiovascular function at rest was affected in a different way: there was a rise in HR, clear enhancement of cardiac systolic performance, and a considerable drop in the estimated total peripheral vascular resistance, associated with median 1-RRA and 2-RRA occupancies of 88 and 34%, respectively. The cardiovascular effects of celiprolol were not affected by pretreatment with bisoprolol. Celiprolol thus binds extensively to 1-adrenoceptors, moderately to 2-adrenoceptors, acts as 1-adrenergic antagonist (exemplified by the ergometric effects) but has vasodilator, positive chronotropic and cardiac systolic performance enhancing properties, which do not involve either direct or indirect 1-adrenergic agonism, but which might reflect 2-adrenergic agonism. 相似文献
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目的:制备富马酸氯马斯汀干混悬剂。方法:考察常用的羟丙基甲基纤维素(HPMC)、羧甲基纤维素钠(CMC-Na)、聚维酮(PVPK90)、黄原胶、甲基纤维素(MC)等辅料对干混悬剂的影响。通过对其沉降体积比、再分散性指标的考察,筛选了2%HPMC作为助悬剂,从流变学、混悬剂黏度及显微形态的观察对其稳定性进行研究。同时考察了药物在加速试验下粒子形态的稳定性。结果:所制干混悬剂工艺简单、稳定性良好,形成混悬液,符合干混悬剂的各项质量标准。结论:本品达到干混悬剂要求,制剂质量稳定。 相似文献
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Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP139–151 peptide. The effect of treating these mice with 1α,25-Dihydroxyvitamin D3 (vitamin D3), or with monomethyl fumarate (MMF) was then examined. We observed that both vitamin D3 and MMF inhibited and/or prevented EAE in these mice. These findings were corroborated with isolating natural killer (NK) cells from vitamin D3-treated or MMF-treated EAE mice that lysed immature or mature dendritic cells. The results support and extend other findings indicating that an important mechanism of action for drugs used to treat multiple sclerosis (MS) is to enhance NK cell lysis of dendritic cells. 相似文献