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目的 研究番石榴叶乙醇提取物的化学成分。方法 利用硅胶柱色谱、中压液相色谱、高效液相色谱等色谱技术对番石榴叶乙醇提取物的成分进行分离纯化,通过波谱数据分析,鉴定化合物的结构。结果 从番石榴叶中共分离鉴定10个化合物,分别为: guajadial(1)、psiguajadial G(2)、guajadial C(3)、psiguajadial E(4)、physcion(5)、4-methoxy-6-phenyl-2H-pyran-2-one(6)、(6S, 8R)-loliolide(7)、teuhetenone A(8)、(R)-(–)-mellein methyl ether(9)、2-羟基苯甲酸苄酯(10)。结论 化合物1–4为混源萜类化合物,化合物5-10为首次从番石榴中分离得到。利用X-射线单晶衍射方法对化合物1和7的绝对构型进行了确证。 相似文献
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Alejandro Madrid Luis Espinoza Cesar González Marco Mellado Joan Villena Rocío Santander Viviana Silva Iván Montenegro 《Journal of ethnopharmacology》2012
Ethnopharmacological relevance
Psoralea glandulosa L. (Fabaceae) is a medicinal resinous shrub used in Chilean folk medicine as antiseptic in treatment of infections and skin diseases caused by bacteria and fungus.Aim of the study
To evaluate the in vitro antifungal activity of the resin and the active components from P. glandulosa against clinical yeast isolates.Materials and methods
Active compounds were obtained of the resinous exudate from aerial parts of P. glandulosa. Eight species of yeast were exposed to the resin and two major compounds. Minimum inhibitory concentration (MIC80) was determined according to the standard broth microdilution method.Results
Bakuchiol and 3-hydroxy-bakuchiol demonstrated potent activity with the MIC80 ranging from 4 to >16 and 0.125 to 16 μg/mL, respectively. The resin had some degree of antifungal activity.Conclusions
The overall results provided important information for the potential application of the 3-hydroxy-bakuchiol from P. glandulosa in the therapy of serious infection and skin diseases caused by clinical yeast. 相似文献3.
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