柳州市2004～2009年城市道路交通伤害的流行病学研究

目的 探讨柳州城市道路交通伤害的流行病学规律,为预防和控制伤害的发生及其危害提供依据.方法 应用广西公安厅交警总队提供的数据和2004～2009年柳州市统计年鉴描述柳州市道路交通伤害的发生率、死亡率、伤人率和直接经济损失及其变化趋势,并描述道路交通伤害的车辆类型、地区和道路分布情况等相关特征.结果 2004～2009年柳州城市道路交通伤害在总体上发生率、死亡率和伤人率呈下降趋势,但2009年4项数据有回升趋势,直接经济损失为69.9万元,是2008年的1.90倍,受伤人数为252人,是2008年的2.50倍,2项数据升高较快;2004～2009年间柳州市道路交通伤害的主要成因是与道路交通伤害相关的人员因素,所占比例为61.80％～91.03％,其中机动车驾驶员的违章行为是主要原因,包括纵向间距不够和酒后驾驶等;发生交通伤害的主要车种为汽车和摩托车,两者所占比例每年都超过90％以上;交通伤害主要发生在城市主干道上,占76％左右.结论 柳州市道路交通伤害发生率得到了有效控制,适当控制汽车保有量的快速增长对于减少道路交通伤害作用明显;柳州城市道路交通伤害的预防和控制应以控制汽车驾驶员和摩托车驾驶员的违章行为为重点,同时增加警力,加强城市主干道的监督检查.     

Pharmacokinetic analyses using absorption kinetics in low-alcohol dose cases of drunken driving

In Japan, low-alcohol dose cases of drunken driving, where drivers drink just before getting behind the wheel, are increasing for expert witnesses since the penalties for drunken driving have become stricter. Widmark’s equation has generally been used for the pharmacokinetic analysis of blood alcohol concentration, which encompasses the one-compartment model with zero-order elimination kinetics but ignores absorption kinetics. We therefore propose that the formula might not be applicable to the analysis of low-alcohol dose cases of drunken driving because the issue is focused on the absorption phase. In this paper, we present two representative low-alcohol dose cases, which were analyzed using the one-compartment model with first-order absorption and zero-order elimination kinetics. This formula is thought to be more suitable and useful for medicolegal practice than Widmark’s formula.     

醉酒后致颅脑损伤多病例分析

目的通过分析80例酒后驾驶致颅脑损伤患者,探讨颅脑损伤患者的临床特点,病情危重情况,以及抢救治疗措施,为更有效挽救患者生命总结经验。方法收集2010年6月-2012年6月80例醉酒后致颅脑损伤患者的病例资料,回顾分析患者的病情和治疗措施。结果有效治疗68例、12例死亡,死亡率为15%。结论醉酒往往导致患者意识障碍、反应迟缓、自我防护能力明显下降,因此临床症状复杂,病情危重、诊断困难、合并症多、致死率高。     

Age-Related Differences in Risks of Drinking and Driving in Gender and Ethnic Groups

We examine the extent to which empirically observed age-related differences in rates of drinking and driving can be explained by concurrent differences in drinking patterns. Building on previous research showing significant age differences in drinking patterns between men and women and among three ethnic groups, Whites, Blacks, and Hispanics, our study considers whether there are unique gender and ethnic group differences in patterns of drinking and driving. Data were from 4395 respondents 12 to 80 years old in a general population survey of 20 urban areas in the United States. During the month preceding the interview, 1130 (25.7%) of all respondents had driven after having one or more drinks. Drinking pattern measures included drinking frequency, average drinking quantity, and the variance in the number of drinks consumed per occasion. To assess the relationships of drinking patterns to drinking and driving across age groups, two sets of analyses were conducted, one set in which age differences in drinking patterns were statistically controlled and one set in which they were not Although the statistical control for drinking patterns reduced age differences between gender and ethnic groups, it did not eliminate them. The reduction demonstrated that part of observed group differences in driving after drinking over age among gender and ethnic groups is due to age-related differences in drinking patterns. However, despite controlling drinking patterns young respondents remained more likely to drink and drive. A supplementary analysis of self-reported incidents of driving while intoxicated (i.e., driving after having five or mora drinks) further indicated that, controlling for drinking patterns, young respondents are most at risk.     

The “drunken honeycomb” feature of pulmonary mucinous adenocarcinoma: A diagnostic pitfall of bronchial brushing cytology

Pulmonary mucinous adenocarcinoma (PMA) is the terminology recently proposed in the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) International Multidisciplinary Classification of Lung Adenocarcinoma Guidelines for most tumors previously classified as mucinous bronchioloalveolar carcinomas (mBACs). PMA is histologically characterized by lepidic growth and at least some degree of invasive growth of goblet or columnar neoplastic cells with abundant intracytoplasmic mucin. We report here the cytologic features of PMA in a bronchial brushing specimen. The patient is an 84‐year‐old woman with a persistent dense consolidation in the right middle lobe of the lung found on non‐contrast computed tomography (CT) scan. Bronchial brushing smears showed a monotonous population of columnar neoplastic cells forming “drunken honeycomb”‐like cell clusters. The neoplastic cells displayed inconspicuous cytologic atypia. The concurrent transbronchial tissue biopsy and the resection specimen confirmed the diagnosis of PMA. Due to the bland nuclear features, the neoplastic cells in the bronchial brushing specimen were interpreted as benign at the time of the initial diagnosis, demonstrating a diagnostic pitfall of bronchial brushing cytology. A high index of suspicion is recommended when a lung lesion with “drunken honeycomb”‐like cell clusters is encountered in bronchial brushing specimens. The review of the literature regarding the recently designated PMA is presented. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.     

Blow and Go: The Breath-Analyzed Ignition Interlock Device as a Technological Response to DWI

Driving while intoxicated rates have declined substantially in the last 20 years. This is as a result of public opinion combined with increased law enforcement efforts. A recent tool has been the Breath Analyzed Ignition Interlock Device. This new technology is designed to prevent persons with excessive blood alcohol levels from operating the interlocked vehicle. This 3-year recidivism study of the ignition interlock revealed 17.5% recidivism rates for the interlock group compared to 25.3% recidivism rates for the non-interlock group, a 31% decrease. Multiple offenders and younger (under 30) offenders had significantly lower rates of subsequent arrests. The multi-offenders in the comparison group were more than twice as likely as the interlock group to have a subsequent conviction within 3 years. The difference was nearly the same for the under 30 age group. There was almost no difference for first offenders. Accordingly, the ignition interlock appears to significantly reduce recidivism for repeat and younger DWI offenders but offers almost no improvement for first offenders. One driver of 315 (0.32%) was charged with DWI with an interlock in place. This offender had a child provide the breath sample while she drove the vehicle.     

醒酒浓缩液的药效学研究

OBJECTIVETo observe Anti-drunken Condensed Liquor's effect on the mouse in relation to its keeping away from drunkenness as well as the liquor's anti-drunken effect. METHODSUsing the drinking device to test the time(min) in which the mice's symptom disapp