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《Nutrition, metabolism, and cardiovascular diseases : NMCD》2019,29(10):1030-1039
Background and aimThis network meta-analysis (NMA) compares the effects of different types of olive oil (OO) on cardiovascular risk factors.Methods and resultsLiterature search was conducted on three electronic databases (Medline, Web of Science, and Cochrane Central). Inclusion criteria: Randomized controlled trials (RCTs) (≥3 weeks duration of intervention) comparing at least two of the following types of OO: refined OO (ROO), mixed OO (MOO), low phenolic (extra) virgin OO (LP(E)VOO), and high phenolic (extra) virgin OO (HP(E)VOO). Random-effects NMA was performed for seven outcomes; and surface under the cumulative ranking curve (SUCRA) was estimated, using an analytical approach (P-score). Thirteen RCTs (16 reports) with 611 mainly healthy participants (mean age: 26–70 years) were identified. No differences for total cholesterol, HDL-cholesterol, triacylglycerols, and diastolic blood pressure were observed comparing ROO, MOO, LP(E)VOO and HP(E)VOO. HP(E)VOO slightly reduce LDL-cholesterol (LDL-C) compared to LP(E)VOO (mean difference [MD]: −0.14 mmol/L, 95%–CI: −0.28, −0.01). Both, HP(E)VOO and LP(E)VOO reduces SBP compared to ROO (range of MD: −2.99 to −2.87 mmHg), and HP(E)VOO may improve oxidized LDL-cholesterol (oxLDL-C) compared to ROO (standardized MD: −0.68, 95%–CI: −1.31, −0.04). In secondary analyses, EVOO may reduce oxLDL-C compared to ROO, and a dose-response relationship between higher intakes of phenolic compounds from OO and lower SBP and oxLDL-C values was detected. HP(E)VOO was ranked as best treatment for LDL-C (P-score: 0.83), oxLDL-C (0.88), and SBP (0.75).ConclusionsHP(E)VOO may improve some cardiovascular risk factors, however, public health implications are limited by overall low or moderate certainty of evidence. 相似文献
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Hamida Hamdi 《Andrologia》2019,51(10)
Sertraline is an antidepressant medication used extensively in the therapy of depression. The present investigation was intended to estimate the actual protective role of wheat germ oil on sertraline‐caused testicular injury in albino rats. Sertraline (human therapeutic dose, 15.63 mg/kg) was orally administrated to rats for 28 successive days. Sertraline‐administered rats were concurrently supplemented with wheat germ oil (human therapeutic dose, 68.75 mg/kg) for 28 successive days. Sertraline administration induced an elevation in testicular DNA damage and acute testicular damage illustrated by the histopathological alterations including marked degeneration and necrosis of germ cells lining seminiferous tubules, as well as interstitial oedema, congestion of interstitial blood vessel. Wheat germ oil administration potentially mitigated the histopathological alterations of sertraline‐administered rats. Lipid peroxidation, oxidative stress biomarker, showed a significant elevation in testicular tissue of sertraline‐administered rats. Furthermore, glutathione content and catalase activity were decreased in testicular tissue of sertraline‐administered rats. Serum testosterone level was elevated in sertraline‐administered rats. Wheat germ oil significantly reduced lipid peroxidation of testicular tissue and improved the antioxidant defences. Finally, wheat germ oil has a preventive role against testicular damage induced by sertraline in rats probably via its potential to prevent reactive oxygen species. 相似文献
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棕榈油对成人血脂和血小板功能的影响 总被引:3,自引:0,他引:3
报道了棕榈油(PA),花生油(PE)对血清总胆固醇水平(TC)在5.5~7.0mmol/L的受试者血脂和血小板功能的影响。51名受试者(男31人,女20人,年龄30~66岁之间)分为两组,一组男15人,女11人,称PE组;另一组男16人女9人,称PA组,预备期3周,膳食以当地日常食用的花生油烹调,实验期6周。PA组受试者食用以棕榈油烹调的实验膳;PE组受试者仍食花生油烹调的膳食。脂肪约占膳食能量的30%,其中60%~65%来自实验油。实验结果表明:与起始值相比,6周末PA组受试者血清TC,低密度脂蛋白胆固醇(LDL-C)和总胆固醇与高密度脂蛋白胆固醇比值(TC/HDL-C)显著下降,血浆血栓素B2(TXB2)/6-酮前列环素F1α、(6-keto-PGF1α)比值显著下降,全血血小板聚集率未见显著变化。PE组受试者的血脂、血浆TXB2、6-keto-PGF1α及全血血小板聚集率等指标均未出现显著变化。提示,棕榈油作为我国居民家庭烹调用油并不会增加发生心血管疾病的危险。 相似文献
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烹调油烟致大小鼠肺癌的实验研究 总被引:1,自引:0,他引:1
[目的]了解烹调油烟(cooking oil fumes,COF)的动物致癌性。[方法]采用动式染毒法给Balb/c小鼠(雌雄各半)吸入COF浓度为9.09、20.65、38.85mg/m^3,染毒1次/1~2d,30min/次,共150次,计8个月;SD大鼠(雌雄各半)吸入COF浓度为6、88、15.06、35.33mg/m^3,染毒1次/2d,30min/次,共191次,计12.5个月。分别制备COF慢性中毒动物模型;两实验均设空白对照组,吸入与实验组相同温度的清洁空气。[结果]COF诱发Balb/c小鼠实验组肺癌总发生率为18、95%(29/153),低、中、高浓度组肺癌发生率分别为15.09%、20、00%和22.00%,与对照组差异均有显著性。但低、中、高三组间差异无显著性(P〉0.05);COF诱发SD大鼠肺癌总发生率为9、10%(9/99),低、中、高浓度组肺癌发生率分别为6.45%、8.57%、12.12%,高浓度组肺癌发生率高于对照组(P〈0.05)。各性别组间肺癌发生率的差别无显著性(P〉0.05)。[结论]COF可以诱导Balb/c小鼠和SD大鼠肺癌,诱发的肺癌主要为肺腺癌(小鼠28/29,大鼠7/9),余为小细胞肺癌。 相似文献
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目的:比较普拉固和鱼油对高胆固醇血症患者的血脂、血粘度、血管内皮功能和心脑血管事件的影响。方法:对266例原发性高胆固醇血症患者经2周洗脱期后,随机分为两组,普拉固组,初服10mg,每晚一次,8周后若TC仍>5.2mmol/L,LDL—ch>3.12mmol/L,则加量至20mg/d,每8周再查血脂,以达到TC<5.2mmol/L,LDL—ch<3.12mmol/L的量作治疗量继续服用。鱼油组,服美国深海鱼油一日三次,一次3g,均于服药8周复查血脂、血粘度及血管内皮功能等并作16月随访。结果:治疗8周,TC,普拉固组下降26%,鱼油组下降12%(P<0.01)。LDL—ch,普拉固组下降31%,鱼油组下降11%(P<0.01),肱动脉流量介导的舒张与硝酸甘油介导的舒张,普拉固组分别增加104%和19%,鱼油组无明显改变。全血低切粘度,普拉固组减少23%,鱼油组减少10%(P<0.01)。平均随访16月,普拉固组中脑出血1例(0.8%),鱼油组发生心脑血管事件7例(5.3%),死亡1例(P<0.05)。两组均无明显的不良反应。结论:普拉固是一个安全有效的降脂药,能改善血管内皮功能,降低血粘度,减少高胆固醇血症病人心脑血管事件发生。 相似文献
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Summary Three species of digeneans including 1 Gorgoderidae (Plesiochorus cymbiformis) from the urinary bladder, 1 Plagiorchiidae (Enodiotrema megachondrus) from the duodenum, and 1 Pachypsolidae (Pachypsolus irroratus) from the stomach were recovered from 2 of 3 olive ridley turtles (Lepidochelys olivacea) found stranded along the Pacific coast of Costa Rica. All trematodes represent new locality records. Histopathological changes
associated with eggs of cardiovascular flukes (Digenea, Spirorchiidae) were described from the lungs, spleen, and intestine
of a single turtle. 相似文献
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Ramona A. Cole Anita Bansal Debra M. Moriarity William A. Haber William N. Setzer 《Journal of natural medicines》2007,61(4):414-417
The leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by GC–MS. The principal constituents of
E. zuchowskiae leaf oil were α-pinene (28.3%), β-caryophyllene (13.2%), α-humulene (13.1%), and α-copaene (8.1%). The leaf essential oil
of E. zuchowskiae showed pronounced in-vitro cytotoxic activity against MCF-7, MDA-MB-468, and UACC-257 human tumor cell lines. The major components
showed cytotoxic activities comparable to doxorubicin (LC50 14–70 μg/ml). 相似文献