全文获取类型
收费全文 | 12372篇 |
免费 | 1075篇 |
国内免费 | 284篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 1142篇 |
妇产科学 | 201篇 |
基础医学 | 973篇 |
口腔科学 | 96篇 |
临床医学 | 1350篇 |
内科学 | 3409篇 |
皮肤病学 | 54篇 |
神经病学 | 466篇 |
特种医学 | 572篇 |
外国民族医学 | 2篇 |
外科学 | 581篇 |
综合类 | 1523篇 |
现状与发展 | 1篇 |
预防医学 | 1437篇 |
眼科学 | 55篇 |
药学 | 954篇 |
5篇 | |
中国医学 | 430篇 |
肿瘤学 | 456篇 |
出版年
2024年 | 31篇 |
2023年 | 174篇 |
2022年 | 470篇 |
2021年 | 565篇 |
2020年 | 368篇 |
2019年 | 360篇 |
2018年 | 395篇 |
2017年 | 433篇 |
2016年 | 461篇 |
2015年 | 512篇 |
2014年 | 731篇 |
2013年 | 1058篇 |
2012年 | 596篇 |
2011年 | 717篇 |
2010年 | 537篇 |
2009年 | 574篇 |
2008年 | 524篇 |
2007年 | 559篇 |
2006年 | 488篇 |
2005年 | 471篇 |
2004年 | 405篇 |
2003年 | 323篇 |
2002年 | 312篇 |
2001年 | 249篇 |
2000年 | 163篇 |
1999年 | 157篇 |
1998年 | 172篇 |
1997年 | 147篇 |
1996年 | 176篇 |
1995年 | 146篇 |
1994年 | 141篇 |
1993年 | 120篇 |
1992年 | 104篇 |
1991年 | 97篇 |
1990年 | 84篇 |
1989年 | 104篇 |
1988年 | 104篇 |
1987年 | 74篇 |
1986年 | 82篇 |
1985年 | 82篇 |
1984年 | 60篇 |
1983年 | 51篇 |
1982年 | 52篇 |
1981年 | 46篇 |
1980年 | 40篇 |
1979年 | 55篇 |
1978年 | 40篇 |
1977年 | 32篇 |
1976年 | 26篇 |
1975年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Comprehensive evidence regarding the treatment of non-anaemic iron deficiency in patients undergoing valvular heart surgery is lacking. This study aimed to investigate the association between non-anaemic iron deficiency and postoperative outcomes in these patients. We retrospectively analysed 321 patients of which 180 (56%) had iron deficiency (defined as serum ferritin < 100 ng.ml-1 or < 300 ng.ml-1 with transferrin saturation < 20%). While the iron-deficient group had lower pre-operative haemoglobin levels than the non-iron deficient group (median (IQR [range]) 134 (127–141 [120–172]) g.l-1, 143 (133–150 [120–179]) g.l-1, p = 0.001), there was no between-group difference in allogeneic red blood cell transfusion. Median (IQR [range]) days alive and out of hospital at postoperative day 90 was 1 day shorter in the iron-deficient group (80 (77–82 [9–85]) days vs. 81 (79–83 [0–85]) days, p = 0.026). In multivariable analysis, only cardiopulmonary bypass duration (p = 0.032) and intra-operative allogeneic red blood cell transfusion (p = 0.011) were significantly associated with reduced days alive and out of hospital at postoperative day 90. Iron deficiency did not exert any adverse influence on secondary outcomes except length of hospital stay. Our findings indicate that non-anaemic iron deficiency alone is not associated with adverse effects in patients undergoing valvular heart surgery when it does not translate into an increased risk of allogeneic transfusion. 相似文献
2.
3.
《European journal of surgical oncology》2022,48(2):326-332
BackgroundIn patients with melanoma, sentinel lymph node (SLN) status is pivotal for treatment decisions. Current routine for SLN detection combines Technetium99m (Tc99) lymphoscintigraphy and blue dye (BD). The primary aim of this study was to examine the feasibility of using a low dose of superparamagnetic iron oxide (SPIO) injected intracutaneously to detect and identify the SLN, and the secondary aim was to investigate if a low dose of SPIO would enable a preoperative MRI-evaluation of SLN status.MethodsPatients with melanoma of the extremities were eligible. Before surgery, a baseline MRI of the nodal basin was followed by an injection of a low dose (0.02–0.5 mL) of SPIO and then a second MRI (SPIO-MRI). Tc99 and BD was used in parallel and all nodes with a superparamagnetic and/or radioactive signal were harvested and analyzed.ResultsFifteen patients were included and the SLNB procedure was successful in all patients (27 SLNs removed). All superparamagnetic SLNs were visualized by MRI corresponding to the same nodes on scintigraphy. Micrometastatic deposits were identified in four SLNs taken from three patients, and SPIO-MRI correctly predicted two of the metastases. There was an association between MRI artefacts in the lymph node and the dose SPIO given.DiscussionIt is feasible to detect SLN in patients with melanoma using a low dose of SPIO injected intracutaneously compared with the standard dual technique. A low dose of SPIO reduces the lymph node MRI artefacts, opening up for a non-invasive assessment of SLN status in patients with cancer. 相似文献
4.
Signaling by the transforming growth factor-β (TGF-β) superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDS), contributing to ineffective hematopoiesis and clinical cytopenias. TGF-β, activins and growth differentiation factors exert inhibitory effects on red cell formation by activating canonical SMAD2/3 pathway signaling. SMAD2/3 overactivation is seen in numerous subtypes of MDS. Furthermore, reduced levels of inhibitory SMAD7 are 相似文献
References
- 1.Valcarcel D, Verma A, Platzbecker U, et al. Phase 2 Study of Monotherapy Galunisertib (LY2157299 Monohydrate) in Very Low-, Low-, and Intermediate-Risk Patients with Myelodysplastic Syndromes. Blood. 2015;126:1669.
- 2.Suragani RN, Cawley SM, Li R, Wallner S, et al. Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia. Blood. 2014 Jun 19;123(25):3864-72.
- 3.Dussiot M, Maciel TT, Fricot A, et al. Nat Med. 2014 Apr;20(4):398-407.
- 4.
5.
6.
目的探讨8周基础军训(basic military training,BMT)对入伍新兵血像中红细胞及其相关指标的影响,为指导科学的军事训练提供参考。方法数据来自新疆边防部队2015年度入伍的50名男性新兵,分别在BMT前后测定并记录受试新兵的红细胞计数、血红蛋白浓度及血清铁蛋白等。结果经过8周的BMT,新兵血液中血红蛋白浓度、红细胞计数及血清铁蛋白均显著下降(P0.05,P0.01)。结论 8周BMT可能导致入伍新兵发生运动性贫血,铁缺乏可能是其主要原因。 相似文献
7.
8.
9.
10.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217