BACKGROUND: There is concern that shrimp-allergic individuals may react to glucosamine-containing products as shrimp shells are a major source of glucosamine used for human consumption. OBJECTIVE: The purpose of this study was to determine whether shrimp-allergic individuals can tolerate therapeutic doses of glucosamine. METHODS: Subjects with a history of shrimp allergy were recruited and tested for both shrimp reactivity via a prick skin test and shrimp-specific IgE by an ImmunoCAP assay. Fifteen subjects with positive skin tests to shrimp and an ImmunoCAP class level of two or greater were selected for a double-blind placebo-controlled food challenge (DBPCFC) using glucosamine-chondroitin tablets containing 1,500 mg of synthetically produced (control) or shrimp-derived glucosamine. Immediate reactions, including changes in peak flow and blood pressure, and delayed reactions (up to 24 h post-challenge) via questionnaire were noted and assessed. RESULTS: All subjects tolerated 1,500 mg of both shrimp-derived or synthetic glucosamine without incident of an immediate hypersensitivity response. Peak flows and blood pressures remained constant, and no subject had symptoms of a delayed reaction 24 h later. CONCLUSION: This study demonstrates that glucosamine supplements from specific manufacturers do not contain clinically relevant levels of shrimp allergen and therefore appear to pose no threat to shrimp-allergic individuals. 相似文献
This review focuses on the role of glycosylation during the development of joint inflammation and degeneration. Although glycoproteins and glycan-binding proteins have essential functions in bone and cartilage, and in the inflammatory process, their exact roles are still uncertain due to the vast complexity of carbohydrate structures. Glycosylated epitopes have been shown to play a role in the induction of arthritis in animal models. Currently available drugs are aimed at the protection of cartilage and bone structures but new developments in this area should take into account the tight and specific interactions between bone and cartilage. It is anticipated that new agents will help to remodel damaged joints, based on knowledge of cartilage and bone turnover and on the exact role of glycosylated molecules and cell surface receptor glycoproteins in these processes. Highly sensitive imaging techniques and well-characterized In vivo models will accelerate this development. 相似文献
Background: In the last few years, there has been increasing demand for aesthetic procedures to improve the effects of skin aging.
Aim: To evaluate the anti-aging efficacy, tolerability and skin changes induced by the topical products containing hyaluronic acid, N-acetyl glucosamine and gamma-amino butyric acid through instrumental techniques, clinical and subjective evaluation.
Patients/Method: Twenty female enrolled applied a day and night cream after applying a serum, once week applied a mask, for 2 months. A clinical assessment of smoothness, expression wrinkles, fine wrinkles and measurements of the parameters using Reveal Imager, X-Rite, Corneometer, Dermalab, Moisture Meter EpiD were taken at day 0, 15, 30 and 60 of study period. A final assessment questionnaire was submitted.
Results: The products were accepted by all the volunteers. The hydration (Corneometer: T0 49.17 vs T60 61.11, average variation 24.28%) (Moisture Meter EpiD: T0 45.73 vs T60 61.10, average variation 33.60%), elasticity (Dermalab: T0 56.06 vs T60 62.78, average variation 11.98%) and lightening of the skin (X-Rite: T0 60.23 vs T60 63.36, average variation 5.26%) improved. All changes were statistically significant (p < 0.05).
Conclusion: The efficacy of the topical products is confirmed by subjective, clinical and instrumental assessment. This should be a routine approach in dermatologic practice. 相似文献
Aggregation‐induced emission (AIE) dye‐based fluorescent glycopolymers nanoparticles (FGNs) are synthesized with abundant carbohydrate groups on the surface for the first time. This is carried out firstly by free radical polymerization between AIE monomer (PhE) and a renewable biobased monomer itaconic anhydride (ITA), then by the ring‐opening reaction between ITA and glucosamine hydrochloride, to obtain glycopolymers with plenty of glycosyl groups on them. The resulted amphiphilic glycopolymer is prone to self‐assemble into nanoparticles with high water dispersibility due to the surplus carboxyl groups and glycosyl groups covered on the surface, which can also be further functionalized. The obtained nanoparticles demonstrate strong fluorescence emission, owning to the AIE dyes in the core of nanoparticles. Biocompatibility evaluation and cell uptake behavior of the nanoparticles are further investigated to explore their potential biomedical applications; the demonstrated excellent biocompatibility makes them promising for cell imaging.
Effects of the compositions of lignocellulosic substrate including hemicellulose, cellulose, lignin, and protein on the glucosamine content in biomass of Trichoderma reesei TISTR3080 were studied. A synthetic solid surface media containing different ratios of xylan (hemicellulose), carboxymethyl cellulose (cellulose), lignin, and various concentrations of yeast extract (source of protein) were used to cultivated T. reesei. Regression analysis identified significant individual and interaction factors that affected glucosamine quantity in T. reesei biomass. A regression model was developed to estimate the glucosamine content in biomass of T. reesei from the compositions of the lignocellulosic substrate. An acceptable error (not more than 10%) of the regression model was obtained from validation with the experimental results of glucosamine content in biomass of T. reesei cultivated on lignocellulosic solid surface media made from copra waste and banana peel. 相似文献