全文获取类型
收费全文 | 32724篇 |
免费 | 4350篇 |
国内免费 | 566篇 |
专业分类
耳鼻咽喉 | 120篇 |
儿科学 | 1242篇 |
妇产科学 | 1419篇 |
基础医学 | 2478篇 |
口腔科学 | 810篇 |
临床医学 | 3495篇 |
内科学 | 7438篇 |
皮肤病学 | 173篇 |
神经病学 | 2932篇 |
特种医学 | 533篇 |
外国民族医学 | 4篇 |
外科学 | 3760篇 |
综合类 | 2898篇 |
现状与发展 | 6篇 |
一般理论 | 1篇 |
预防医学 | 4966篇 |
眼科学 | 264篇 |
药学 | 1588篇 |
26篇 | |
中国医学 | 488篇 |
肿瘤学 | 2999篇 |
出版年
2024年 | 101篇 |
2023年 | 1012篇 |
2022年 | 1090篇 |
2021年 | 2304篇 |
2020年 | 1958篇 |
2019年 | 1884篇 |
2018年 | 1692篇 |
2017年 | 1572篇 |
2016年 | 1565篇 |
2015年 | 1464篇 |
2014年 | 2250篇 |
2013年 | 2654篇 |
2012年 | 1750篇 |
2011年 | 1702篇 |
2010年 | 1289篇 |
2009年 | 1373篇 |
2008年 | 1345篇 |
2007年 | 1323篇 |
2006年 | 1203篇 |
2005年 | 995篇 |
2004年 | 855篇 |
2003年 | 760篇 |
2002年 | 649篇 |
2001年 | 556篇 |
2000年 | 421篇 |
1999年 | 371篇 |
1998年 | 404篇 |
1997年 | 337篇 |
1996年 | 313篇 |
1995年 | 289篇 |
1994年 | 254篇 |
1993年 | 254篇 |
1992年 | 219篇 |
1991年 | 186篇 |
1990年 | 156篇 |
1989年 | 147篇 |
1988年 | 153篇 |
1987年 | 105篇 |
1986年 | 116篇 |
1985年 | 119篇 |
1984年 | 105篇 |
1983年 | 56篇 |
1982年 | 66篇 |
1981年 | 40篇 |
1980年 | 34篇 |
1979年 | 33篇 |
1978年 | 17篇 |
1977年 | 16篇 |
1976年 | 17篇 |
1968年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
1.
Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are
increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic
methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent.
Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography
(UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure
the expression levels of miR-144-5p and miR-26b-5p in the plasma of patients with BC. The receiver operating characteristics (ROC) curve and area under the curve (AUC) were used to investigate the potential diagnostic value of miR-
144-5p, miR-26b-5p and the elastographic score in BC. Results: The ultrasonic elastography score(UES) was found to
be significantly upregulated in BC compared with that in benign breast lesions, and the AUC, sensitivity and specificity
were 0.809, 0.717 and 0.806 for distinguishing BC from benign breast lesions, respectively. miR-144-5p and miR-26b-
5p were found to be upregulated in the plasma of BC patients, and miR-144-5p+miR-26b-5p had 0.781 sensitivity and
0.780 specificity for the diagnosis of BC. Furthermore, we found that the diagnostic performance of miR-144-5p and
miR-26b-5p combined with UES for BC had 0.913 sensitivity and 0.890 specificity. Conclusions: The combination of
plasma miR-144-5p, miR-26b-5p and UES has a very high clinical application value for the early detection of BC. 相似文献
2.
《American journal of surgery》2023,225(1):198-205
BackgroundLiver resection is commonly performed for hepatic tumors, however preoperative risk stratification remains challenging. We evaluated the performance of contemporary prediction models for short-term mortality after liver resection in patients with and without cirrhosis.MethodsThis retrospective cohort study examined National Surgical Quality Improvement Program data. We included patients who underwent liver resections from 2014 to 2019. VOCAL-Penn, MELD, MELD-Na, ALBI, and Mayo risk scores were evaluated in terms of model discrimination and calibration for 30-day post-operative mortality.ResultsA total 15,198 patients underwent liver resection, of whom 249 (1.6%) experienced 30-day post-operative mortality. The VOCAL-Penn score had the highest discrimination (area under the ROC curve [AUC] 0.74) compared to all other models. The VOCAL-Penn score similarly outperformed other models in patients with (AUC 0.70) and without (AUC 0.74) cirrhosis.ConclusionThe VOCAL-Penn score demonstrated superior predictive performance for 30-day post-operative mortality after liver resection as compared to existing clinical standards. 相似文献
3.
4.
5.
6.
7.
Raymond J. Chan RN PhD Vivienne E. Milch MBBS MHPol Fiona Crawford-Williams PhD Oluwaseyifunmi Andi Agbejule BRadTherapy Ria Joseph MNutrDiet Jolyn Johal BND Narayanee Dick BSc Matthew P. Wallen PhD Julie Ratcliffe PhD Anupriya Agarwal MBBS Larissa Nekhlyudov MD Matthew Tieu PhD Manaf Al-Momani BPharm Scott Turnbull PhD Rahul Sathiaraj MPH Dorothy Keefe MBBS MD Nicolas H. Hart PhD 《CA: a cancer journal for clinicians》2023,73(6):565-589
Patient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty-four reviews were quantitative or mixed-methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost-effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost-effectiveness of navigation in screening programs. 相似文献
8.
9.
10.
目的 建立苏州市肺结核发病的SARIMA模型并预测发病,为苏州市肺结核防控提供参考。方法 收集结核病信息管理系统(新)中苏州市2010年1月—2018年12月肺结核月发病数,通过时间序列分析建立SARIMA模型并预测苏州市2019年肺结核的发病情况。结果 苏州市肺结核发病数具有明显的季节周期性,每年的发病最高峰为5月,发病最低谷为2月。苏州市肺结核发病数的最佳拟合模型为SARIMA (0,1,1)×(0,1,1)12,AIC=9.590,SBC=9.644,模型参数均具有统计学意义,模型残差为白噪声序列,模型的预测值与实际值平均绝对百分比误差MAPE=7.943%,模型预测精度较高。预测苏州市2019年肺结核发病数为3 467例,月发病数平均值为289例,发病水平较2018年略有下降。结论 SARIMA(0,1,1)×(0,1,1)12模型能较好拟合出苏州市肺结核发病数的时间变化趋势,可应用于苏州市肺结核月发病数的短期预测。 相似文献