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目的:以内毒素攻击肝组织,造成肝损伤家兔模型,探讨二十五味松石丸对家兔内毒素性肝损伤的影响,并观察家兔肝脏组织形态学变化。方法:将30只家兔随机分为5组,分别为模型组,二十五味松石丸高、中、低剂量组(0.5,0.167,0.06 g·kg~(-1)),地塞米松组(0.005 g·kg~(-1)),每组6只,每日ig给药1次,连续5 d,模型组和地塞米松组分别以等量生理盐水ig,在第5天灌药前分别用内毒素攻击预先ig的家兔,比较各组家兔于造模12 h内的死亡情况,检测各组家兔体温、血常规以及肝功能情况,并采用苏木素-伊红(HE)观察各组家兔肝脏组织病理学变化。结果:二十五味松石丸高剂量能降低内毒素血症家兔血清总胆红素及丙氨酸氨基转移酶,肝脏病理损伤明显减轻,二十五味松石丸低剂量能降低内毒素血症家兔血清天门冬氨酸氨基转移酶以及血液白细胞总数,与模型组比较均具有明显的统计学差异(P0.05)。结论:二十位味松石丸对家兔内毒素性肝损伤具有一定的保护作用。 相似文献
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目的：通过初步了解二十五味松石丸的配伍特点及其治疗肝病的核心组合成分,以期为藏药方剂组方的优化及新药研发提供思路与方法。方法：本研究通过查阅《四部医典》、《新修晶珠本草》等藏医药典籍,概括二十五味松石丸中所含25味药的“味”、“性效”并分析二十五味松石丸的药“味”、“性效”的配伍特点,整理出21种常用治疗肝病的藏药方剂,统计二十五味松石丸的各成分药在21种常用治疗肝病藏药方剂中单味药的使用频次和药对配伍频次,并进行分析。结论：结果表明,二十五味松石丸是以清热药配伍为主的组方,主要治疗热性肝病,其核心组合成分为西红花和牛黄。 相似文献
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Liang Chen Cornelis Johannes Kleverlaan Kunneng Liang Deqin Yang 《The Journal of prosthetic dentistry》2017,117(4):552-558
Statement of problem
Polyvinyl siloxane impression material has been widely used as a lingual matrix for rebuilding missing tooth structure with composite resin. The composite resin is light polymerized in contact with the polyvinyl siloxane impression material. However, polyvinyl siloxane impression material has been shown to interact with other dental materials.Purpose
The purpose of this study was to assess the effect of polyvinyl siloxane impression materials on the polymerization of composite resins by assessing the Vickers microhardness and degree of conversion of polyvinyl siloxane.Material and methods
The composite resins were light polymerized in contact with 3 polyvinyl siloxane impression materials (Flexitime Easy Putty; President Light Body; Xantopren L Blue) (n=8) and in contact with a matrix strip as the control group (n=8). Vickers microhardness and degree of conversion on contact surfaces were measured to evaluate the polymerization of composite resins. The depth of the effect was assessed by Vickers microhardness on section surfaces and observed with scanning electron microscopy. The results were analyzed by 1-way analysis of variance and the post hoc Tukey honest significant differences test (α=.05).Results
The Vickers microhardness and degree of conversion values on the contact surfaces of the experiment groups were significantly lower than those of the control group (P<.05); the Vickers microhardness values on the section surfaces indicated that there was no significant difference at the same depth of different groups (P>.05). The scanning electron microscope observation showed that an approximately 10-μm deep unpolymerized layer was found in the experimental group.Conclusions
Polyvinyl siloxane impression materials have an inhibitory effect on the polymerization of the composite resins, but just limited to within approximately 10 μm from the surface in contact with the impression material. 相似文献7.
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