全文获取类型
收费全文 | 2585篇 |
免费 | 99篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 24篇 |
妇产科学 | 30篇 |
基础医学 | 328篇 |
口腔科学 | 7篇 |
临床医学 | 124篇 |
内科学 | 80篇 |
皮肤病学 | 10篇 |
神经病学 | 1164篇 |
特种医学 | 20篇 |
外科学 | 354篇 |
综合类 | 214篇 |
预防医学 | 56篇 |
眼科学 | 23篇 |
药学 | 219篇 |
2篇 | |
中国医学 | 9篇 |
肿瘤学 | 14篇 |
出版年
2024年 | 4篇 |
2023年 | 40篇 |
2022年 | 75篇 |
2021年 | 100篇 |
2020年 | 96篇 |
2019年 | 81篇 |
2018年 | 100篇 |
2017年 | 114篇 |
2016年 | 115篇 |
2015年 | 109篇 |
2014年 | 186篇 |
2013年 | 299篇 |
2012年 | 145篇 |
2011年 | 209篇 |
2010年 | 140篇 |
2009年 | 153篇 |
2008年 | 143篇 |
2007年 | 120篇 |
2006年 | 80篇 |
2005年 | 72篇 |
2004年 | 52篇 |
2003年 | 51篇 |
2002年 | 37篇 |
2001年 | 30篇 |
2000年 | 15篇 |
1999年 | 12篇 |
1998年 | 14篇 |
1997年 | 8篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 8篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 14篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
排序方式: 共有2699条查询结果,搜索用时 31 毫秒
1.
2.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
3.
4.
Gabriele Masi Giulio Perugi Cristina Toni Stefania Millepiedi Maria Mucci Nicoletta Bertini Hagop S Akiskal 《Neuropsychopharmacology》2006,59(7):603-610
BACKGROUND: Recent research has addressed the issue of subtyping juvenile bipolar disorder (JBD). Accordingly, we set out to find out, in a naturalistic sample of bipolar children and adolescents with mania and mixed mania, whether the most useful subtyping should be based on clinical features (elated vs. irritable) or course (episodic vs. chronic). METHODS: We studied 136 patients, 81 male patients (59.6%) and 55 female patients (40.4%), mean age 13.5 +/- 2.9 years, meeting the DSM-IV diagnosis of bipolar disorder, assessed by a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version [K-SADS-PL]). RESULTS: Regarding course, 77 patients (56.6%) had an episodic course and 59 patients (43.4%) had a chronic course. Patients with chronic course were significantly younger, had an earlier onset of JBD, and presented a more frequent comorbidity with disruptive behavior disorders. According to the prevalent mood disturbance, 75 patients (55.1%) showed an elated and 61 patients (44.9%) showed an irritable mood. Elated mood was more frequent in patients with episodic course, whereas irritable mood was more frequent in the patients with chronic course. CONCLUSIONS: These findings suggest that chronic versus episodic course may be a putative differential feature. Further validation of such a distinction would require prospective studies, temperament evaluation, gender and neurobiologic approaches, and differential psychopharmacologic assignment and response. 相似文献
5.
Harry Pantazopoulos Nicholas Lange Ross J Baldessarini Sabina Berretta 《Neuropsychopharmacology》2007,61(5):640-652
BACKGROUND: Growing evidence indicates that the entorhinal cortex (ECx) might be affected in schizophrenia (SZ) and bipolar disorder (BD). To test whether distinct interneuronal subpopulations might be altered, numbers of parvalbumin-immunoreactive (PVB-IR) neurons were measured in the ECx of BD and SZ subjects. These neurons play a pivotal role within ECx intrinsic circuits. METHODS: Numbers, numerical density, and soma size of PVB-IR neurons were measured in the ECx of normal control (n = 16), BD (n = 10), and SZ (n = 10) subjects. The volume of the ECx was measured in Nissl-stained sections. RESULTS: In BD, decreases of total numbers (p = .02) and numerical densities (p = .01) of PVB-IR neurons were detected in the ECx. Within distinct subregions, reductions were detected in the superficial layers of the lateral (p = .02), intermediate (p = .04), and caudal (p = .01) ECx. In SZ, total numbers and numerical densities were not altered. A reduction of soma size was present in the intermediate ECx (p = .01). Volume was unaffected in either disorder. CONCLUSIONS: In BD, a decrease of PVB-IR neurons may alter intrinsic inhibitory networks within the superficial layers of the ECx. The likely consequence is a disruption of integration and transfer of information from the cerebral cortex to the hippocampus. 相似文献
6.
7.
宫腔镜双极电切除子宫黏膜下肌瘤300例临床分析 总被引:1,自引:0,他引:1
目的评价应用双极电能治疗子宫黏膜下肌瘤的优势和安全性。方法应用官腔镜双极电切除子宫黏膜下肌瘤300例,其中0型212例,Ⅰ型54例,Ⅱ型34例。结果术中膨宫液总用量500~2000ml,平均626ml,手术时间20~50min,平均25min,术中出血量10—20ml。1例术中心脑综合征,经及时处理缓解。无一例因疼痛而中止手术。切除肌瘤直径3—5cm,平均3.8cm。1例术后病理为平滑肌肉瘤,术后10天行广泛全子宫切除及盆腔淋巴结清扫术。277例术后随访1—24个月,40例(Ⅰ型12例,Ⅱ型28例)需再次宫腔镜手术。结论宫腔镜下双极电治疗子宫黏膜下肌瘤具有安全、损伤小、恢复快、高效率等特点,宜于推广。 相似文献
8.
9.
Comorbid disorders in hospitalized bipolar adolescents compared with unipolar depressed adolescents 总被引:2,自引:0,他引:2
Carrie M. Borchardt MD Gail A. Bernstein MD 《Child psychiatry and human development》1995,26(1):11-18
This study examined comorbid psychiatric disorders in adolescents with bipolar disorder. Hospitalized bipolar adolescents
(N=10) were compared to hospitalized adolescents with unipolar depression (N=33), and to adolescents with nonaffective psychiatric
disorders (N=11). Results showed conduct disorder, attention-deficit hyperactivity disorder, psychosis, and having any DSM-III-R
psychoactive substance use disorder were all significantly more common in the bipolar group than the unipolar depressed group.
Comorbid anxiety disorder was present in 40–45% of the subjects in the unipolar and bipolar groups, but in none of the control
group subjects.
This study is supported in part by a grant to Dr. Borchardt from the University of Minnesota Graduate School. 相似文献
10.
[摘要] 目的 对比分析人工肱骨头置换术和肱骨近端锁定钢板治疗老年复杂肱骨近端骨折的近期疗效。方法 回顾性分析本院骨科2012年1月~2014年6月采用人工肱骨头置换术和肱骨近端锁定钢板治疗的老年(年龄>65岁)NeerⅢ、Ⅳ部分肱骨近端骨折患者54例,人工肱骨头置换治疗(置换组)30例,肱骨近端锁定钢板内固定治疗(内固定组)24例。比较分析两组手术时间、术中出血量、随访Neer评分及Constant-Murley评分来评定两组临床疗效。结果 两组随访时间相仿,平均随访时间为19.5个月(12~36个月)。内固定组手术时间(101±13)分钟,术中出血量(237.9±32.4)mL,Neer评分(82.5±3.2),Constant-Murley评分(71.7±5.0);置换组手术时间(98±11)分钟,术中出血量(246.0±39.8)mL,Neer评分(82.9±4.5),Constant-Murley评分(73.5±5.0)。两组手术时间、术中出血量、随访Neer及Constant-Murley评分比较差异均无统计学意义(P>0.05)。内固定组有1例出现肩关节半脱位,肱骨头置换组有2例出现肩关节半脱位,通过三角巾悬吊后关节脱位均得到纠正。有1例四部分骨折患者,行内固定术后出现内固定松动、肱骨头坏死,改行人工肱骨头置换术。结论 人工肱骨头置换术和肱骨近端锁定钢板治疗老年肱骨近端复杂骨折的近期临床疗效相似,对不可修复的肱骨近端骨折宜行肱骨头置换术。 相似文献