“调任通督”法针刺治疗围绝经期潮热的随机对照研究＊

目的 观察“调任通督法”针刺治疗围绝经期潮热的临床疗效和安全性。方法 将符合纳入标准的72例围绝经期潮热患者，按照1∶1的比例随机分为治疗组（针刺组）和对照组（等待组）。治疗组取穴百会、印堂、神庭、关元、气海、中脘、阴郄、太溪、复溜、三阴交。针刺治疗每次持续30 min，每周2次，连续治疗6周。对照组为等待组，试验期间仅给予同针刺组相同的健康宣教，两组分别于治疗前、治疗第3周、治疗第6周以及第10周随访评估其潮热频率和程度，以及更年期生活质量量表（Menopause-specific quality of life questionnaire，Men-QoL）的变化情况，同时记录针刺不良事件的发生。结果 ①潮热频率及潮热程度：在治疗后及随访时，针刺组较等待组有明显改善，差异具有统计学意义（P < 0.01）。与治疗前相比，针刺组第3周即出现了潮热频率明显下降的趋势（P < 0.01），治疗后以及随访期针刺组潮热频率及潮热程度均较治疗前有明显统计学差异（P < 0.01）。而等待组在各时间点潮热频率及潮热程度均无统计学差异（均P > 0.05）。②围绝经期生活质量量表：治疗后针刺组在Men-QoL总分、血管舒缩功能评分、社会心理、体能状况较等待组比较均有统计学差异（均P < 0.01）。在随访期，针刺组在Men-QoL社会心理以及体能方面明显改善，差异均具有统计学意义（P < 0.01，P < 0.05）。两组Men-QoL性功能在治疗后及随访期均无统计学差异（P > 0.05）。与治疗前相比，在治疗后及随访期，针刺组Men-QoL总分、血管舒缩功能、社会心理、体能状况均有统计学差异（均P < 0.05），在Men-QoL性功能方面无统计学差异（P > 0.05）。等待组在Men-QoL总分及四个域方面均无明显改善，无统计学意义（均P > 0.05）。结论 调任通督法针刺治疗围绝经期潮热安全有效，且对围绝经期生活质量有所改善。     

汤岗子矿泉浴对大鼠血液皮质醇及甲状腺素日生物周期节律影响的实验观察

本文报告大鼠分别在6时、12时、18时、24时接受汤岗子矿泉38～39℃浸浴15分钟后,立即断头取血测定血液皮质醇及甲状腺素(T_4)。在6时、24时的矿泉浸浴组大鼠血浆皮质醇比对照组明显升高。在12时、18时矿泉浸浴组大鼠血清T_4比对照组明显升高。说明肾上腺皮质及甲状腺功能对全身矿泉浸浴热刺激的反应也遵循日周期节律。为矿泉治疗的时间生物学理论提供依据。     

Natural history of extensive Mongolian spots in mucopolysaccharidosis type II (Hunter syndrome): a survey among 52 Japanese patients

BACKGROUND: Recent reports have shown a correlation between extensive Mongolian spots and mucopolysaccharidosis type II (Hunter syndrome). However, a statistical survey of the incidence and natural history of extensive Mongolian spots among the patients with Hunter syndrome is lacking. OBJECTIVES: To determine the prevalence of extensive Mongolian spots, to determine the natural course of the spots according to age in Japanese patients with Hunter syndrome, and to compare them with the results obtained from the patients' brothers who did not have Hunter syndrome. PATIENTS/METHODS: Fifty-two males with Hunter syndrome aged 3 to 40 years were studied. Twenty-five patients were examined in two clinics to determine the existence and characteristics of the spots. We interviewed their families about the spots in their neonates and the natural course of the spots according to their ages. The same survey was done among another 27 patients using a mailed questionnaire to their families. As control, we investigated 21 brothers of the patients by a mailed questionnaire to their families. RESULTS: The extensive Mongolian spots are identified in almost all the infants with Hunter syndrome and disappear extremely later in their life. The lesions had a high incidence of deep-blue hyperpigmentation. Regardless of age, the overall incidence was 78%. All of the brothers who did not have Hunter syndrome had common-type Mongolian spots in neonates, which regressed during their childhood. CONCLUSION: Our results confirm a strong correlation between extensive Mongolian spots and Hunter syndrome for the Japanese population. The presence of extensive Mongolian blue spots should alert the physician to the possibility of Hunter syndrome.     

淡色库蚊不同发育阶段双向电泳的蛋白质多肽点图谱比较

用双向电泳分析淡色库蚊卵、二令幼虫、四令幼虫、蛹和成虫蛋白质组成.电泳完毕后,用考马斯亮兰G-250染色,结果以成蚊蛋白质多肽点为最多(116点),其次依次为蛹(101点)、卵(70点)、四令幼虫(53点)、二令幼虫(18点)。它们在不同分子量和不同PH 范围内的分布也不同,但总的来看,在幼体阶段(卵、二、四令幼虫及蛹)多偏低分子量和低PI 值的点,发育至成虫阶段,分布走向全面。     

Increased reactivity to chemical but not to heat noxious stimuli in mice producing anti-idiotypic antibodies for substance P

Mice immunized against anti-substance P (anti-SP) monoclonal antibodies produced anti-SP anti-idiotypic antibodies (SPAb2). In a previous report. SPAb2 antibodies were found to have in vitro biological activity i.e. to behave either as agonists or as antagonists for substance P (SP) depending on the biological test. In this study, the involvement of SPAb2 in vivo biological activity has been tested. Because of the possible implication of SP in the generation and transmission of nociceptive information, we have tested the responsiveness of SPAb2 responding mice in behavioral nociceptive tests. SPAb2 mice showed very small behavioral variations in the hot plate test as compared with a control group of mice immunized against an unrelated monoclonal antibody. In the formalin test, however, SPAb2 mice displayed a significant increase in paw licking time, which was significantly correleted with SPAb2 serum concentration. These results are discussed in terms of the use of SPAb2 as pharmacological tools for studying the biological properties of SP receptors and more generally of auto anti-idiotypic antibodies in modulating behavior responses.     

亚低温治疗高温高湿环境下重型颅脑损伤的临床护理

目的 探讨亚低温治疗高温高湿环境下重型颅脑损伤的护理方法。方法 高温高湿环境下的重型颅脑损伤患者60例，随机分为亚低温治疗组和对照组。规范护理程序，严密观察病人生命体征变化，采取积极护理措施，减少并发症。结果 亚低温治疗24h后颅内压逐渐下降，脑组织PO2逐渐上升，伤后3个月亚低温治疗组的良好率明显高于对照组（P〈0.05），而死亡率明显低于对照组（P〈0．01）。结论 精心护理有助于改善亚低温治疗的高温高湿环境下重型颅脑损伤病人的预后。     

高温高湿环境下守岛官兵训练时脑血流和脑电生理的变化研究

目的 探讨高温高湿环境下守岛官兵训练前后脑血流和脑电生理的变化,为临床防治热致疾病提供依据.方法 从守岛官兵中随机抽取在常温常湿环境下温度(27.40±1.37)℃,湿度(50.25±6.76)%]新兵100名为常温新兵组,高温高湿环境下(温度≥35℃,湿度≥80%)新兵100名为高温新兵组;高温高湿环境下服役2～3 年的官兵100名为高温老兵组.受试者负重15 kg,分次在3000 m/15 min,5000 m/30 min和10 000 m/45 min内完成跑步训练.10 000 m训练后,根据受试者脑血流高低又分为脑血流增高组(24名)、脑血流降低组(46名)和脑血流正常组(230名).训练前后行经颅多普勒血流诊断仪和脑电图仪检测.结果 (1)3000 m训练后3组受试官兵脑平均血流速度(Vm)较训练前均显著增高(P＜0.01),但5000 m和10 000 m训练后,常温新兵组降低6%和16%,高温老兵组降低5%和15%,高温新兵组降低14%和31%,比常温新兵组和高温老兵组低(P＜0.01);(2)10 000 m训练前后3组脑电图均在正常范围,3组比较差异无统计学意义(P＞0.05);(3)10 000 m训练后脑血流增高组和降低组脑电图比正常血流组活跃(P＜0.01).结论 高温高湿环境下10 000 m训练对官兵的脑血流有较大的影响,但对脑电生理无影响,老兵在此环境下则表现出较好的热耐受力和适应性.     

蒙古族,汉族新生儿蒙古斑研究

目的：调查蒙古族、汉族、蒙汉后裔新生儿蒙古斑的出现情况。方法：观察蒙古斑的数量、颜色、分布、面积，进行分析。结果与结论：蒙古斑出现率蒙古族为７８．７９％，汉族为７３．５４％，蒙汉后裔为８３．７０％。蒙古斑出现率无性别间差异。蒙古斑多分布于臂部和骶尾部。在有斑者中，人均斑面积为０．００２０ｍ＾２左右，斑面积与体表表面的比值多小于２％。     

Post-capillary venules in the “milky spots” of the greater omentum are the major site of plasma protein and leukocyte extravasation in rodent models of peritonitis

Intraperitoneal injection of inflammatory agents in the mouse and rat causes plasma protein and leukocyte extravasation into the peritoneal cavity. Following an intraperitoneal injection of zymosan A, the milky spots of the omentum were the only abdominal sites detected where intravenously administered Monastral Blue labeled interendothelial cell gaps responsible for plasma extravasation. In addition, when colored microspheres were intraventricularly administered to quantify blood flow, the omentum was the only abdominal organ which showed an increase in blood flow during zymosan A peritonitis. A combination of light and electron microscopy, plus measurement of myeloperoxidase activity (a marker of neutrophil accumulation) demonstrated that the omental milky spots are the major route through which leukocytes migrate into the peritoneal cavity. Identical structures in the pleura likewise are the sites of protein leakage into the pleural cavity. In contrast, selective sites of protein and cellular extravasation could not be detected in the synovial lining of the inflamed knee joint.