四种络合剂对小鼠体内170^Tm促排效果的比较

应用小鼠对四种络合剂的~(170)Tm内污染促排效果进行了比较性研究。结果表明,~(170)Tm内污染后,立即给促排剂400μM/kg,Ca-DTPA效果最好;在延迟给促排剂情况下,Zn-DTPA与Ca-DTPA等效,且优于811(喹胺酸)和EDTA。     

四种络合剂对241Am促排效果的比较

应用200只天鼠研究了²⁴¹Am内污染时四种络合剂(Ca-DTPA, Zn-DTPA,嗤胺酸钠盐和H-73-IO)钓促排效果.实验目的是为²⁴¹Am内污染治疗确定首先促排药物及制定最佳促排方案.实验结果表明:在四种结合剂中Ca-DTPA和Zn-DTPA促排效果为最佳,能使骨²⁴¹Am含量降低到对照组的10%,肝²⁴¹Am含量降低到对照组的5%左右.喹胺酸钠盐在降低骨、肝²⁴¹Am含量方面也有效(统计上与DTPA无显著差别),但能导致肾脏²⁴¹Am蓄积,甚至略高于对照组.H-73-10虽有-些效果,但远不及DTPA.     

The influence of age on the efficiency of delayed therapy with Ca-DTPA for cerium in rats

The influence of age on the effectiveness of chelation therapy starting 24 h after cerium administration was studied in 2- and 6-week-old rats. ¹⁴¹Ce was administered IP, followed after 24 and 48 h by IP administration of trisodium calcium diethylenetriaminepentaacetate (Ca-DTPA). The whole body and organ retention of ¹⁴¹Ce was determined 6 days after its administration. The chelation therapy significantly reduced cerium retention in both age groups but was more efficient in older animals. This age-related effect was, however, less pronounced than after immediate treatment with DTPA observed in our previous experiments, indicating that age as one of the factors which influence the efficacy of chelation treatment is probably more important in conditions of early than in conditions of delayed therapy.