Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D,Vitamin C,Melatonin, and Zinc

More than one year has passed since the first cases of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS)-CoV-2 coronavirus were reported in Wuhan (China), rapidly evolving into a global pandemic. This infectious disease has become a major public health challenge in the world. Unfortunately, to date, no specific antivirals have been proven to be effective against COVID-19, and although a few vaccines are available, the mortality rate is not decreasing but is still increasing. One therapeutic strategy has been focused on infection prevention and control measures. In this regard, the use of nutraceutical supports may play a role against some aspect of the infection, particularly the inflammatory state and the immune system function of patients, thus representing a strategy to control the worst outcomes of this pandemic. For this reason, we performed an overview including meta-analyses and systematic reviews to assess the association among melatonin, vitamin C, vitamin D, zinc supplementation and inflammatory markers using three databases, namely, MEDLINE, PubMed Central and the Cochrane Library of Systematic Reviews. According to the evidence available, an intake of 50,000 IU/month of vitamin D showed efficacy in CRP. An amount of 1 to 2 g per day of vitamin C demonstrated efficacy both in CRP and endothelial function, and a dosage of melatonin ranging from 5 to 25 mg /day showed good evidence of efficacy in CRP, TNF and IL6. A dose of 50 mg/day of elemental zinc supplementation showed positive results in CRP. Based on the data reported in this review, the public health system could consider whether it is possible to supplement the current limited preventive measures through targeted nutraceutical large-scale administration.     

运动负荷平板系统程序引起的故障

本文详细叙述了美国GP公司TM210运动负荷平板系统由于仪器比较老,而且是在DOS状态下工作,运行程序经常无缘无故出错,经过一段时间的摸索,找到了简单的方法,迅速修复,保证了设备的正常运行。     

The efficacy of moxibustion and acupuncture therapy for ankylosing spondylitis: A protocol for an overview of systematic reviews and meta-analysis

Background:Ankylosing spondylitis is a complex and progressive autoimmune inflammatory disease with a worldwide prevalence ranging up to 0.9%. Several systematic reviews and meta-analyses of traditional Chinese medicine alternative therapies, such as acupuncture or moxibustion, have demonstrated the effectiveness of moxibustion and acupuncture in the treatment of ankylosing spondylitis. However, there is no relevant literature to comprehensively evaluate the evidence. The purpose of this overview is to synthesize and evaluate the reliability of evidence generated in the systematic review (SR) and meta-analysis of moxibustion and acupuncture as a primary or complementary therapy for patients with ankylosing spondylitis.Methods:PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database were searched for systematic reviews and meta-analysis that review the efficacy of acupuncture or moxibustion as the primary treatment for patients with Ankylosing Spondylitis. The literature published before August 2020 will be selected. Additionally, the relevant SRs and meta-analyses that unpublished or ongoing will be searched in PROSPERO and INPLASY. The methodological guidelines for overviews will be used to review and extract data by 2 reviewers, and their will do it independently. Methodology quality will be analyzed by the assessment of multiple systematic reviews-2and the risk of bias by POBIS. For the included studies, we will adopt the following results as primary evaluation indicators: effective rate, visual analogue scale and bath AS disease activity index. Reviewers will assess the certainty of evidence by Grading of Recommendations Assessment, Development and Evaluation.Results:The results will be published in a peer-reviewed journal.Conclusion:This overview will provide comprehensive evidence of moxibustion and acupuncture for patients with Ankylosing Spondylitis.     

锁骨近端骨折治疗进展

锁骨近端骨折发病率极低,一般行保守治疗。对于须行手术治疗的患者,因该处解剖结构比较特殊,并缺乏特定内固定材料,稳妥固定难度较大,临床上一直在探索一种比较好的内固定方式。我们对锁骨近端骨折的治疗进展进行综述。     

PART 2: Practice and research recommendations for quality developmental care in the NICU

Developmental care interventions, which may promote preterm infant's neurodevelopment during the hospitalization in the Neonatal Intensive Care Unit, should be implemented and integrated to care delivered by nurses, other healthcare professionals, and parents. These interventions may have an impact on the preterm infants' developing brain and optimize their short and long-term health outcomes. Based on a previous narrative overview, more high-quality research is still needed in this field. Nevertheless, best practice of developmental care can still be recommended to improve today's neonatal clinical practice. The aim of this article is to provide both practice and research recommendations according to the seven categories of developmental care interventions in the neonatal intensive care unit: family-centered care, sleep protection, assessment and management of pain, infant positioning, optimized infant-driven feeding, administration of human milk, and control of the environmental light and noise.     

中医药治疗糖尿病视网膜病变回眸研究

糖尿病视网膜病变的病因病机以气阴亏虚为本,气滞血瘀为标,并临床实践中辨病与辨证相结合,眼底检查与中医脉证互参进行综合辨证治疗,已成为共识.目前临床辨证分型及组方用药较灵活多变,为此统计举出近10年来使用频率前40位和各功能归类中前6位的中药,并综合归纳了基本辨证分型和组方用药,供实验研究和临床使用参考.     

聚甲基丙烯酸甲酯骨水泥对心血管系统影响及其预防的文献分析

目的综述关节置换术中聚甲基丙烯酸甲酯骨水泥对“血管系统的影响及预防措施，为其安全性评价和监管提供依据。方法对检索到的国内骨水泥文献筛选归纳并进行描述性分析。结果关节置换术中骨水泥易产生心血管系统并发症，导致血压下降、心律失常、血栓、肺栓塞等。结论文献分析结果表明，骨水泥的临床应用存在一定的安全性问题，建议临床医生谨慎使用。     

五运六气理论概念体系与当代研究概述

五运六气理论是中医理论的重要内容之一，集中反映了中医学的天人相应和审机辨治观念，通过独具特色的概念体系细致地阐释了其理论原理与运用法则，推动了中医学理论与临床的发展。当代以来，在国内医学专业期刊上发表的相关论文约500篇，相关专业论著也时有面世，研究涉及五运六气理论的理论阐释、临床应用及其科学性界定。通过对《素问》运气七篇的概念梳理，提出包括核心概念、基本概念、衍生概念及关联概念的五运六气理论概念体系。     

Systematic overview of quality of life studies for breast cancer

BACKGROUND: The concept of quality of life (QOL) is essentially subjective, determined from the patient's point of view. Thus, an appropriate investigation and analysis of QOL as an indicator of medical treatment outcome is a task of some difficulty. The physician-led QOL assessment studies to date in Japan have suffered from insufficient knowledge and understanding of the diverse factors contributing to QOL, thereby contributing to a dearth of quality studies. Given this background, the Japanese Breast Cancer Society has established a Task Force for the development of guidelines to properly conduct QOL assessment studies. The present article reports the results of a large-scale systematic overview of QOL assessment studies for breast cancer patients that was undertaken as one part of this project. METHODS: Six databases were used in this overview: MEDLINE, CINAHL, CANCERLIT, EMBASE, PsychINFO, and Japan Centra Revuo Medicina. The search period was 1982-1999 for CINAHL, and 1990-1999 for the others. Following a check of the titles, important information was recorded on relevance and data collection forms. RESULTS: A systematic search was conducted of the literature on QOL assessment studies for breast cancer patients, and 1,954 articles were extracted from a check of titles. Using the relevance and data collection forms, the number of articles was further narrowed to 126. These articles were then classified according to the type and design of the study, the number of QOL and psychological measures used, frequency of use of each measure, and study focus and type of intervention. The results were then compiled. CONCLUSION: To date there have been almost no appropriate systematic overviews or guidelines issued for QOL assessment studies related to breast cancer, even on the international level. The results of the present study may contribute high-quality QOL information for evidence-based medicine, as it continues to gain global prevalence.     

复合型可注射型骨替代材料在骨缺损临床应用的研究进展

摘要： 目的：总结了各种复合型可注射骨替代材料的特点及其临床应用 资料来源：综述相关文献主要来源于Pubmed 数据库，重庆维普数据库和清华同方数据库 资料选择：选择可注射型骨替代材料的特点和在临床中应用的最新相关文献，排除陈旧及重复实验的相关文献 结局评价指标：以最新的实验结果和研究热点为本综述的结局评价指标 结果：根据最新的相关文献，介绍各种复合型可注射骨替代材料的优缺点和治疗骨缺损的临床疗效 结论：复合型可注射骨替代材料在临床上治疗骨缺损有广阔的应用前景