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1.
Siyu Chen Xuhong Hou Yu Sun Gang Hu Xiaoyan Zhou Huijuan Xue Peizhu Chen Jingzhu Wu Yuqian Bao Weiping Jia 《Primary Care Diabetes》2018,12(3):231-237
Aims
To assess whether an integrated hospital-community diabetes management program could improve major cardiovascular risk factor control among patients with diabetes in real-world clinical settings.Methods
985 adults with diabetes in the Shanghai Taopu community health service center were enrolled at baseline and 907 subjects completed the follow-up. The follow-up levels of the metabolic profiles were assessed by their averages during the follow up period.Results
After a mean 7-year follow-up period, heamoglobin A1c, systolic and diastolic blood pressure levels decreased by 0.6%, 5.7 mmHg, and 1.5 mmHg, respectively (all P < 0.001). There was a non-significant difference in low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol increased 1.9 mg/dL and triglycerides decreased 28.3 mg/dL, respectively (all P < 0.001). The percentage of patients with diabetes who met any one of three Chinese Diabetes Society goals (heamoglobin A1c <7.0%, blood pressure <140/80 mmHg, and low-density lipoprotein cholesterol <100 mg/dL) increased from 58.2% to 70.1%. The chronic diabetes complication screening rates (diabetic retinopathy, diabetic neuropathy, diabetic nephropathy) have significantly increased, from almost zero to 12–78%.Conclusions
This long-term program has increased the proportions of attaining major cardiovascular risk factors control goals and diabetic chronic complication screening rates among patients with diabetes. 相似文献2.
目的:探讨血清肌酐(SCr)、内皮素-1(ET-1)、肾损伤分子-1(KIM-1)和β2-微球蛋白(β2-MG)的水平在妊娠期高血压疾病并发早期肾损伤的临床意义。方法:将妊娠期高血压疾病并发肾损伤的孕产妇40例设为肾病组,同期正常孕产妇40例设为对照组,分别在孕龄30周、32周、34周、36周检测孕妇血SCr、ET-1、尿KIM-1和β2-MG的水平。结果:1肾病组与对照组比较,患者的年龄、孕次和流产史均无统计学差异(P0.05),尿量、尿素氮(BUN)、SCr及尿蛋白定量均存在统计学差异(P0.001);2肾病组和对照组整体比较,SCr、ET-1、KIM-1和β2-MG的组间、时间点间的交互作用均有统计学差异(P0.05);3孕36周SCr、孕32周KIM-1及孕34周ET-1和β2-MG水平肾病组与对照组组间存在统计学差异(P0.05);4对照组组内不同孕周间SCr、ET-1、KIM-1和β2-MG水平无统计学差异(P0.05);肾病组组内与孕30周时比,KIM-1水平在孕32周显著升高(P0.05),在孕34周、36周进一步升高(P0.01);ET-1和β2-MG水平在孕34周显著升高(P0.05),而SCr在孕36周显著升高(P0.05)。结论:妊娠期高血压疾病孕妇产前监控中,联合检测SCr、ET-1、KIM-1和β2-MG能及时发现肾损伤的存在;妊娠期高血压疾病并发肾损伤时KIM-1、ET-1和β2-MG的改变早于SCr的改变。 相似文献
3.
玉丹参桂胶囊治疗心肾综合征临床研究 总被引：1，自引：0，他引：1
目的以中西药结合与西药治疗进行对照,研究两种治疗方案对心肾综合征临床症状、体征及实验室指标的影响。方法入选病人60例,随机分为西药组30例、西药+参桂组30例。西药组给予西医基础治疗:安体舒通20mg,口服,每日2次;倍他乐克6.25mg,口服,每日2次;科素亚50 mg,口服,每日1次。西药+参桂组在西药组治疗的基础上加用玉丹参桂胶囊,3粒,口服,每天3次。两组疗程均为30d。结果心肾综合征患者在西医治疗基础上联合中药玉丹参桂胶囊,能更好的改善患者的临床症状、心功能分级等,提高临床疗效,治疗后两组之间比较P<0.05,有统计学差异,但对实验室指标改善作用有限,同单纯西药治疗组相比在大多数指标上未显示出优势(P>0.05)。结论在西药基础治疗的基础上联合使用玉丹参桂胶囊能更好的改善心肾综合征的患者的临床症状、体征、提高心功能分级、改善运动耐量。 相似文献
4.
Objective
Metabolic disturbances are common in patients with renal function impairment and are related to high rates of cardiovascular incidents and mortality. Kidney transplantation leads to improved survival but may lead to additional metabolic alterations caused by immunosuppressive drugs and improved nutrition.Materials and methods
The short-term effect of oral fructose load on serum uric acid (UA), plasma lipids, and blood pressure (BP) was studied in 85 patients with chronic kidney disease (CKD) and impairment of renal function (glomerular filtration rate 50–65 ml/min per 1.73 m2), comprising 55 renal transplant recipients (RTR) treated with standard triple immunosuppressive therapy including a calcineurin inhibitor (CNI) cyclosporine A (CsA) or tacrolimus (Tac) and 30 non-transplanted patients with CKD. Both non-transplanted CKD patients and RTR had stable renal function and a comparable degree of kidney dysfunction. All subjects received orally 70 g of fructose dissolved in 200 ml of water. Serum UA, lipids, and blood pressure were measured at baseline and 60, 120, 180, and 240 minutes after fructose administration.Results
There was a significant increase of serum UA concentration (p < 0.001) in both CKD patients and RTR – CsA- or Tac-treated patients comparable in the latter. Total cholesterol (TC), LDL, and HDL cholesterol significantly decreased and serum triglycerides (TG) markedly increased in RTR, whereas in CKD patients all serum lipid fractions increased. Blood pressure was unaffected by fructose intake.Conclusion
Both non-transplanted and transplanted patients with mild renal function impairment show similar acute purine metabolic disturbances following oral administration of fructose but in the latter dietary fructose may induce a smaller hyperlipidemic response. 相似文献5.
目的:了解NRS2002在预估老年肿瘤患者化疗不良反应的潜在作用及相关影响因素,探讨潜在的化疗不良事件的干预措施。方法:2016年7月至2017年2月选择在我院肿瘤内科就诊的149例老年肿瘤化疗患者作为研究对象,入院24 h内完善NRS2002评分及相关病史采集,评估化疗不良反应分级。结果:149例患者中,有营养不良风险（NRS2002评分≥3分）的老年肿瘤患者占43.6%,无营养风险占56.4%,其中年龄、肿瘤类别分布、化疗不良反应分级、WBC、Hb、Scr、UA及血清K+组间差异有统计学意义（P<0.05）。相关性分析结果显示:不良反应分级与NRS2002评分呈正相关性,与WBC、Hb、SCr、UA及K+、Ca2+呈负相关性。线性回归分析提示NRS2002评分的高低与老年肿瘤患者化疗不良反应分级显著正相关,而SCr则是一个负性预测因子。结论:NRS2002可准确预估老年肿瘤化疗患者面临的潜在化疗风险,早期纠正贫血或可缩小老年肿瘤患者的化疗不良反应风险;肾功不全不再是化疗的绝对禁忌证。 相似文献
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目的:观察中药熏蒸联合血液灌流对尿毒症顽固性皮肤瘙痒患者的临床疗效。方法:将40例尿毒症顽固性皮肤瘙痒患者作为本实验的研究对象,按照随机的原则将患者分为对照组和治疗组,每组各20例,对照组给予常规血液透析联合血液灌流治疗,治疗组在对照组基础之上再给与中药熏蒸进行联合治疗,之后对2组患者的临床疗效以及其他相关指标进行对比分析。结果:对照组总有效率为55.00%,治疗组为95.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组相关指标均有所下降,差异有统计学意义(P<0.05)。2组治疗后相关指标比较,差异有统计学意义(P<0.05)。治疗组皮肤瘙痒评分低于对照组,2组比较,差异有统计学意义(P<0.05)。结论:中药熏蒸联合血液灌流治疗尿毒症顽固性皮肤瘙痒临床治疗效果确切,缓解了临床症状,改善了生活质量。 相似文献
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目的:观察糖肾汤治疗Ⅲ、Ⅳ期糖尿病肾病(DN)的临床疗效。方法:将94例Ⅲ、Ⅳ期DN患者随机均分为对照组和联合组各47例。对照组给予常规治疗,联合组在对照组基础上给予糖肾汤治疗。比较2组患者临床疗效和治疗前、治疗后3个月血糖、血肌酐(SCr)、血尿素氮(BUN)、肾小球滤过率(GFR)等指标的差异。结果:联合组治疗总有效率为91.49%高于对照组的74.47%(P<0.05)。经治疗,2组的血糖水平均改善(P<0.05)。但2组治疗后血糖水平比较,差异无统计学意义(P>0.05)。经治疗,联合组SCr、BUN及GFR水平均较治疗前改善(P<0.05),且优于对照组治疗后(P<0.05)。结论:在常规治疗的基础上,采取糖肾汤治疗Ⅲ、Ⅳ期DN可有效改善患者肾功能,减缓病情进展,可取得理想的临床疗效。 相似文献
9.
Yu-Sen Zhong Chen-Huan Yu Hua-Zhong Ying Zhi-Yuan Wang Hua-Fang Cai 《Journal of ethnopharmacology》2012
Ethnopharmacological relevance
Orthosiphon stamineus (OS) popularly known as “diuretic agent” are traditionally used in folk medicine in the treatment of hyperuricemia, rheumatism, gout, nephritis, nephrolithiasis, urethritis and cystitis.Aim of the study
To evaluate prophylactic potentials of total flavonoids, total phenolics and polysaccharides from OS on experimental induction of calcium oxalate (CaOx) nephrolithiasis in rats.Materials and methods
Nephrolithic rats were induced by treating with 1.0% ethylene glycol and 1.0% ammonium chloride for 7 days. Rats in the treated groups were also given OS extracts at the doses of 80 mg/kg and 160 mg/kg. Urine samples (4 h) and serum samples were collected at 7th day for biochemical analysis. Kidney tissues were stained with H.E. and analyzed by light microscopy. Expressions of OPN protein were detected by immunohistochemistry. Rates of nucleation and aggregation of calcium oxalate crystals were derived from 20-min time-course measurements of optic density at 620 nm after mixing solutions containing calcium chloride, sodium oxalate and OS extracts at 37 °C, pH 5.7.Results
Polysaccharides exhibited the most significant prophylactic effects by reversing BUN and Scr levels, ameliorating histopathological changes, increasing urine C2O42− and Ca2+ excretion and down-regulating OPN protein expression of kidney in the model rats in comparison with those effects of total flavonoids and total phenolics. Polysaccharides could also significantly inhibit both nucleation and aggregation of CaOx crystals.Conclusions
Polysaccharides were the main therapeutic materials in OS. It had impressive prophylactic effects on CaOx stones in nephrolithic rats, playing a role as a regulator of OPN protein expression to increase urine C2O42− and Ca2+ excretion and also as an inhibitor of CaOx crystallization. 相似文献10.