全文获取类型
收费全文 | 1022篇 |
免费 | 60篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 5篇 |
妇产科学 | 39篇 |
基础医学 | 160篇 |
口腔科学 | 14篇 |
临床医学 | 98篇 |
内科学 | 89篇 |
皮肤病学 | 7篇 |
神经病学 | 54篇 |
特种医学 | 37篇 |
外科学 | 58篇 |
综合类 | 138篇 |
预防医学 | 83篇 |
眼科学 | 75篇 |
药学 | 108篇 |
中国医学 | 116篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 10篇 |
2022年 | 37篇 |
2021年 | 54篇 |
2020年 | 33篇 |
2019年 | 32篇 |
2018年 | 23篇 |
2017年 | 23篇 |
2016年 | 29篇 |
2015年 | 35篇 |
2014年 | 87篇 |
2013年 | 58篇 |
2012年 | 83篇 |
2011年 | 78篇 |
2010年 | 64篇 |
2009年 | 55篇 |
2008年 | 56篇 |
2007年 | 54篇 |
2006年 | 42篇 |
2005年 | 24篇 |
2004年 | 33篇 |
2003年 | 24篇 |
2002年 | 15篇 |
2001年 | 15篇 |
2000年 | 14篇 |
1999年 | 10篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 9篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有1109条查询结果,搜索用时 81 毫秒
1.
2.
Walter G. Sannita Luisa Lopez Lino Maggi Guido Rosadini 《Documenta ophthalmologica. Advances in ophthalmology》1988,70(1):89-96
L-acetylcarnitine is a compound with cholinergic properties and putative action on the visual system and the glucose metabolism. Ten healthy, emmertropic volunteers (age range: 21 to 28 years) were studied. Each subject was administered 5, 10, and 30 mg/kg acute intravenous doses of L-acetylcarnitine and matching placebo. Retinal oscillatory potentials to full-field flash stimulation were recorded before and 30, 60, and 120 min after administration. A systematic reduction of the implicit time of the P2 and N2 oscillatory potential components was observed after administration of the 10 and 30 mg/kg doses: significant changes were not evident at the 5 mg dose or after placebo. The latency reduction was significantly correlated with the postdrug increment of the L-acetylcarnitine plasma concentration. No other systematic modification in latency of amplitude was observed.The results were presented in part at the XXV I.S.C.E.V. Symposium, Sarasota (Florida), April 26–30, 1987. 相似文献
3.
4.
Walter G. Sannita Lino Maggi Piero L. Germini Mauro Fioretto 《Documenta ophthalmologica. Advances in ophthalmology》1989,71(4):413-419
Electroretinograms and retinal oscillatory potentials to full-field flash stimulation were recorded by dermal electrodes in a population of subjects (1 to 84 yrs) balanced for age and sex (119 females, 133 males), without evidence or history of ocular and/or relevant systemic diseases. The electroretinogram latencies and b-wave amplitude increased, while the a-wave amplitude decreased linearly with age. The oscillatory potential amplitude initially increased, to decrease approximately at the age of 50, with an inverted U-shaped distribution.Presented in part at the XXV ISCEV Symposium, Sarasota (Florida), April 26–30, 1987. 相似文献
5.
Mice immunized against anti-substance P (anti-SP) monoclonal antibodies produced anti-SP anti-idiotypic antibodies (SPAb2). In a previous report. SPAb2 antibodies were found to have in vitro biological activity i.e. to behave either as agonists or as antagonists for substance P (SP) depending on the biological test. In this study, the involvement of SPAb2 in vivo biological activity has been tested. Because of the possible implication of SP in the generation and transmission of nociceptive information, we have tested the responsiveness of SPAb2 responding mice in behavioral nociceptive tests. SPAb2 mice showed very small behavioral variations in the hot plate test as compared with a control group of mice immunized against an unrelated monoclonal antibody. In the formalin test, however, SPAb2 mice displayed a significant increase in paw licking time, which was significantly correleted with SPAb2 serum concentration. These results are discussed in terms of the use of SPAb2 as pharmacological tools for studying the biological properties of SP receptors and more generally of auto anti-idiotypic antibodies in modulating behavior responses. 相似文献
6.
目的 探讨亚低温治疗高温高湿环境下重型颅脑损伤的护理方法。方法 高温高湿环境下的重型颅脑损伤患者60例,随机分为亚低温治疗组和对照组。规范护理程序,严密观察病人生命体征变化,采取积极护理措施,减少并发症。结果 亚低温治疗24h后颅内压逐渐下降,脑组织PO2逐渐上升,伤后3个月亚低温治疗组的良好率明显高于对照组(P〈0.05),而死亡率明显低于对照组(P〈0.01)。结论 精心护理有助于改善亚低温治疗的高温高湿环境下重型颅脑损伤病人的预后。 相似文献
7.
高温高湿环境下守岛官兵训练时脑血流和脑电生理的变化研究 总被引:1,自引:0,他引:1
目的 探讨高温高湿环境下守岛官兵训练前后脑血流和脑电生理的变化,为临床防治热致疾病提供依据.方法 从守岛官兵中随机抽取在常温常湿环境下温度(27.40±1.37)℃,湿度(50.25±6.76)%]新兵100名为常温新兵组,高温高湿环境下(温度≥35℃,湿度≥80%)新兵100名为高温新兵组;高温高湿环境下服役2~3 年的官兵100名为高温老兵组.受试者负重15 kg,分次在3000 m/15 min,5000 m/30 min和10 000 m/45 min内完成跑步训练.10 000 m训练后,根据受试者脑血流高低又分为脑血流增高组(24名)、脑血流降低组(46名)和脑血流正常组(230名).训练前后行经颅多普勒血流诊断仪和脑电图仪检测.结果 (1)3000 m训练后3组受试官兵脑平均血流速度(Vm)较训练前均显著增高(P<0.01),但5000 m和10 000 m训练后,常温新兵组降低6%和16%,高温老兵组降低5%和15%,高温新兵组降低14%和31%,比常温新兵组和高温老兵组低(P<0.01);(2)10 000 m训练前后3组脑电图均在正常范围,3组比较差异无统计学意义(P>0.05);(3)10 000 m训练后脑血流增高组和降低组脑电图比正常血流组活跃(P<0.01).结论 高温高湿环境下10 000 m训练对官兵的脑血流有较大的影响,但对脑电生理无影响,老兵在此环境下则表现出较好的热耐受力和适应性. 相似文献
8.
Alberto Bacchi-Modena Pierfrancesco Bolis Carlo Campagnoli Fiorenzo De Cicco Michele Meschia Francesco Pansini Roberto Pisati Gabriele Hüls 《Maturitas》1997,27(3):285-292
Objectives: To assess the efficacy and tolerability of a new matrix patch delivering 0.05 mg estradiol per day (Estraderm MX 50) in postmenopausal women with moderate to severe postmenopausal symptoms. Methods: A multicenter, double-blin, randomized, between-patient, placebo controlled trial in 109 postmenopausal women was carried out. Patches were applied twice weekly for 12 weeks. Patients were assessed at 4, 8 and 12 weeks of treatment. The primary efficacy variable was change from baseline in mean number of moderate to severe hot flushes (including night sweats) per 24 h during the last 2 weeks of treatment. Other variables included Kupperman Index, local and systemic tolerability. Plasma concentrations of estradiol (E2), estrone (E1) and estrone sulfate (E1S) were determined before and after treatment. Results: Estraderm MX was significantly superior to placebo (P < 0.001) in reducing mean number of moderate to severe hot flushes (including night sweats) per 24 h after 4, 8 and 12 weeks of treatment. The estimate of treatment group differences after 12 weeks was 4.2 hot flushes (95% confidence interval: 2.6–5.5). Estraderm MX also significantly reduced Kupperman Index at all time points compared to placebo (P < 0.001). Estraderm MX induced increases in mean E2, E1 and E1S plasma levels as expected (E2: baseline 2.7 pg/ml, 12 weeks 38.9 pg/ml; E1: baseline 18.8 pg/ml, 12 weeks 41.6 pg/ml; E1S: baseline 235.6 pg/ml, 12 weeks 765.1 pg/ml). Overall rates of adverse experiences were similar for Estraderm MX and placebo. The number of patients reporting skin irritation was low and similar in both groups. Conclusions: Estraderm MX 50, a new matrix patch, offers an effective and well tolerated dosage form for transdermal delivery of 0.05 mg E2 per day. 相似文献
9.
本文通过用Flash 5.0制作《医学电子学》中PN结的形成过程的介绍,在熟悉Flash 5.0制作方法的同时.完成相应的多媒体教学。 相似文献
10.
Laboratory and Ambulatory Monitoring of Menopausal Hot Flashes 总被引:2,自引:0,他引:2
A large increase in skin conductance activity recorded from the sternum was found during menopausal hot flashes and corresponded well with patient self-reports. The magnitude and time course of this skin conductance change was similar during spontaneous hot flashes recorded in the laboratory, during heat-induced hot flashes, and during those recorded by ambulatory monitoring techniques. This pattern of sternal skin conductance change did not occur in premenopausal women during body heating or ambulatory monitoring. These methods should be useful in research on the etiology and treatment of menopausal hot flashes. 相似文献