全文获取类型
收费全文 | 4867篇 |
免费 | 394篇 |
国内免费 | 41篇 |
专业分类
儿科学 | 5篇 |
妇产科学 | 1530篇 |
基础医学 | 341篇 |
口腔科学 | 8篇 |
临床医学 | 338篇 |
内科学 | 130篇 |
皮肤病学 | 43篇 |
神经病学 | 62篇 |
特种医学 | 172篇 |
外科学 | 228篇 |
综合类 | 824篇 |
预防医学 | 360篇 |
药学 | 331篇 |
1篇 | |
中国医学 | 107篇 |
肿瘤学 | 822篇 |
出版年
2024年 | 8篇 |
2023年 | 74篇 |
2022年 | 167篇 |
2021年 | 193篇 |
2020年 | 133篇 |
2019年 | 146篇 |
2018年 | 163篇 |
2017年 | 185篇 |
2016年 | 168篇 |
2015年 | 192篇 |
2014年 | 395篇 |
2013年 | 327篇 |
2012年 | 401篇 |
2011年 | 340篇 |
2010年 | 282篇 |
2009年 | 281篇 |
2008年 | 265篇 |
2007年 | 263篇 |
2006年 | 233篇 |
2005年 | 189篇 |
2004年 | 166篇 |
2003年 | 101篇 |
2002年 | 100篇 |
2001年 | 112篇 |
2000年 | 71篇 |
1999年 | 43篇 |
1998年 | 54篇 |
1997年 | 22篇 |
1996年 | 20篇 |
1995年 | 27篇 |
1994年 | 23篇 |
1993年 | 17篇 |
1992年 | 14篇 |
1991年 | 12篇 |
1990年 | 20篇 |
1989年 | 12篇 |
1988年 | 14篇 |
1987年 | 6篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 11篇 |
1981年 | 5篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有5302条查询结果,搜索用时 15 毫秒
1.
Yong Luo Yang Zou Li-ping Li Zhao-zhen Wang Li-qun Wang Zi-yu Zhang 《Gynecological endocrinology》2020,36(10):895-901
AbstractOxidative stress (OS) has been proposed to play a role in the development of EMs. Peroxiredoxins are a family of antioxidant proteins that exhibit peroxidase activity in a thioredoxin-dependent manner, protecting cells against OS. The Western blotting results showed that the relative expression of PRDX4 was significantly increased in ectopic endometria compared with the normal endometria of EMs-free (p?<?.05). The H2O2 concentration was also significantly higher in the ectopic endometrium. PRDX4 siRNA was transfected into primary ectopic endometrial stromal cells (EESCs). The viability of the transfected EESCs was measured by CCK-8 assay, and the results showed significantly decreased cell viability. Furthermore, the apoptosis rate and ROS generation in flow cytometry assays were significantly increased after the knockdown of PRDX4 expression (p?<?.05). Scratch assays and transwell assays revealed that decreased expression of PRDX4 mediated by siRNA inhibited EESC migration and invasion. In conclusion, these findings indicate the potential role of PRDX4 in the development of EMs and PRDX4 as a possible therapeutic target for EMs treatment. 相似文献
2.
L Mettler 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2002,6(4):305-309
BACKGROUND AND OBJECTIVES: Evaluation of long-term results using a thermal balloon endometrial ablation technique to treat menorrhagia and hypermenorrhea, considered dysfunctional uterine bleedings. METHODS: A single-arm, prospective study with long-term follow-up of 48 months at the department of obstetrics and gynecology, University of Kiel, Germany. Following hysteroscopic evaluation of the uterine cavity and fractionated curettage, the Cavaterm endometrial thermal ablation technique was performed on 70 patients over the age of 40 with menorrhagia and hypermenorrhea in whom medical treatment had previously failed. The study included a group of 10 patients with adenomyosis and uterine fibroids. RESULTS: In 65 patients, a complete 48-month follow-up evaluation was possible: 58% of patients reported amenorrhea and 33% hypomenorrhea. Nine percent of patients remained eumenorrheic. Fifty percent of the small group with failed indications for the procedure had to undergo a hysterectomy. CONCLUSIONS: The Cavaterm thermal coagulation system in the earlier mode of application (15 minutes at a temperature of 70 degrees C and a pressure of 200 mm Hg) is a safe and highly effective method of endometrial ablation resulting in a minimal amount of posttreatment menstrual bleeding. 相似文献
3.
This case demonstrates that hysteroscopic polypectomy can enhance fertility. A 35-year-old woman was being evaluated for assisted conception. She was referred from an in vitro fertilisation clinic for polypectomy, which she had undergone on two occasions. She conceived spontaneously, had an uneventful antenatal period, and delivered a healthy baby at 39 weeks' gestation. 相似文献
4.
目的:探讨子宫内膜萎缩疗法治疗青春期功血(DUB)的止血效果。方法:将362例平均分为观察组(采用炔诺酮、戊酸雌二醇联合疗法止血)和对照组(单用炔诺酮子宫内膜萎缩疗法止血),两组各181例,比较两组的止血效果。结果:观察组和对照组止血有效率分别为96.13%(174/181)和92.27%(167/181),两组比较差异无统计学意义(踟105);观察组和对照组控制出血时间分别为(28.69±14.87)h和(29.72±15.34)h,两组比较差异无统计学意义(踟.05)。观察组和对照组的完全止血时间分别为(32.80±19.10)h和(47.30±18.60)h,两组比较差异有统计学意义(/9〈0.05)。观察组和对照组的住院天数平均为(6.10±2.80)d和(6.9±2.60)d,观察组住院时间短于对照组(P〈0.01)。结论:炔诺酮止血疗法和炔诺酮、戊酸雌二醇联合疗法治疗青春期功血效果均较好,但炔诺酮、戊酸雌二醇联合疗法治疗效果更佳。 相似文献
5.
A retrospective analysis of treatment for endometrial carcinoma is reported here. From 1987 to 1989, 138 patients were referred to the oncology department following total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometrial cancer. Forty-seven patients were not prescribed postoperative radiotherapy; 31 had Stage I well differentiated adenocarcinoma with minimal myometrial invasion, while the remaining 16 patients were considered unfit for postoperative radiotherapy. There were no instances of local relapse amongst the 31 patients with minimal myometrial invasion.The remaining 91 patients all received external beam irradiation to the pelvis and, according to the preference of the individual therapist, 51 were prescribed additional intracavitary vault caesium-137. Patients receiving postoperative radiotherapy were analysed according to whether or not they received additional intracavitary vault caesium. The two groups were also analysed for incidence of vaginal vault recurrence and treatment related morbidity.In the group receiving additional intracavitary treatment more patients had Stage II or III disease (P<0.05), and had greater depth of myometrial invasion (P<0.05). Vaginal vault recurrence was not observed in patients receiving intracavitary therapy in addition to external beam therapy. Four patients (10%) receiving external beam therapy alone developed vaginal vault recurrence.The incidence of Kottmeier-Perez grade 2 or 3 bowel toxicity following treatment was significantly higher in those patients receiving combined treatment (18% vs. 2.5%; P<0.03). There was also a higher incidence of vaginal stenosis in the group receiving both external beam and intracavitary therapy (21% vs. 3%; P<0.05). There was only one instance of grade 2 bladder toxicity in the external beam and intracavitary treatment group and none in the external beam therapy alone group.In conclusion, postoperative radiotherapy for Stages I-III endometrial carcinoma was carried out in a non-randomized manner by two regimens; either external beam therapy alone or external beam therapy with additional intracavitary vaginal caesium. The combined therapy gave significantly better local control but resulted in significantly more late bowel and vaginal morbidity. 相似文献
6.
目的:探讨子宫内膜增生性病变与子宫内膜癌的超声鉴别诊断及内膜癌肌浸程度的估价.方法:采用术前B超、术后大体标本观察测量,对123例子宫内膜病变患者的声像图资料进行分析并与手术后病理结果对照.结果:①子宫内膜病变者子宫三径之和平均值均大于正常值;②58.6%的子宫内膜增生过长病变患者内膜形态以条形、梭形和正常形态回声;35%的Ⅱ期以上子宫内膜癌患者内膜回声以积液为主兼有其它图像类型;③大于50岁患者不同病理类型病变的子宫内膜平均厚度均超过其正常内膜厚度值,但无明显的规律性.小于50岁的患者内膜增厚主要以子宫内膜增生过长病变为主占48%;④通过超声测量子宫内膜厚度判断子宫内膜癌浅肌层和深肌层浸润符合率均为71.4%.结论:超声检查对判断子宫内膜病变病理类型有一定帮助,内膜厚度、内膜形态、回声特点、及内膜与肌层间的关系等,仅提示病变存在的可能性,要鉴别病变的良恶性、肌层浸润深度,须根据上述回声特点进行综合分析. 相似文献
7.
子宫内膜息肉中雌、孕激素受体的表达 总被引:2,自引:0,他引:2
目的检测子宫内膜息肉雌激素受体(ER)、孕激素受体(PR)的表达,探索子宫内膜息肉形成的原因及机制。方法子宫内膜息肉48例为观察组,正常子宫内膜36例为对照组,采用免疫组化SP法,行半定量分析,检测ER、PR的表达。结果增殖期的息肉组织中PR表达的评分结果为(2.89±2.16),低于增殖内膜的评分(4.04±1.73),差异有统计学意义(P<0.05);分泌期的内膜息肉中ER表达的评分结果为(3.80±1.64),高于分泌期内膜中的评分(2.64±1.45),差异有统计学意义(P<0.05)。结论增殖期的子宫内膜息肉中PR的表达降低及分泌期的息肉中ER表达增高可能参与了子宫内膜息肉的形成及发展。 相似文献
8.
微波子宫内膜去除术治疗异常子宫出血34例疗效观察 总被引:1,自引:0,他引:1
目的探讨微波子宫内膜去除术(microwave endometrial ablation,MEA)治疗异常子宫出血的疗效及安全性。方法采用微波子宫内膜去除术治疗异常子宫出血患者34例,其中功能失调性子宫出血18例,子宫肌瘤16例。结果34例患者术后完成随访3-24个月,闭经19例(55.88%),明显改善7例(20.59%),改善7例(20.59%),月经未改善1例(2.94%),术后随访3月月经过多症状消失,治疗有效率达100%;随访2年后仍达93.3%。结论微波子宫内膜去除术是一种新的治疗异常子宫出血的方法,简便、快速、安全,并发症少。避免了宫腔镜子宫内膜电切术的液体灌注、手术中出血以及子宫穿孔的危险,并取得与之相似甚至更好的疗效。 相似文献
9.
Regional differences in oesophageal motor function 总被引:1,自引:0,他引:1
Abstract We tested the hypotheses that oesophageal bolus transit and motor function vary regionally, with bolus viscosity and with body position. In healthy volunteers, we measured the bolus head advance time, bolus presence time and bolus transit time in the proximal and distal oesophagus using water and viscous materials. We compared concurrent manometric responses. Bolus head advance time, bolus presence time and bolus transit time were longer in the distal oesophagus during water and viscous swallows in the upright and supine positions. The total bolus head advance time and transit time, measured across the entire oesophageal body, were shorter for water than viscous swallows. The amplitudes of peristaltic pressure waves were lower for viscous swallows, and varied as a function of region. These studies demonstrated true functional differences between the proximal and distal oesophagus using multichannel intraluminal impedance and that the viscosity of the bolus is a determinant of oesophageal function. 相似文献
10.
目的 探讨血管生成活性在子宫内膜癌发展中的价值。方法 采用Ⅷ因子相关抗原为标志物 ,以免疫组化技术对正常子宫内膜、不典型增生内膜 ,子宫内膜癌组织进行微血管密度 (MVD)测定。结果 ①正常组与内膜癌组比较 (P <0 .0 1) ,正常组与不典型增生组比较 (P <0 .0 5 ) ;从正常内膜、不典型增生到内膜癌组织内MVD逐渐增多 (P <0 .0 5 )。②内膜癌组织内MVD与肿瘤细胞分化程度有关 (P <0 .0 5 )。结论 临床采用MVD测定对子宫内膜增生病变发展和追随检查具有重要价值 ,同时MVD测定可作为判断子宫内膜癌预后的指标之一。 相似文献