胃肠起搏器治疗胃动力紊乱性疾病

目的：评价胃肠起搏器治疗胃动力紊乱性疾病的有效性和安全性。方法：胃肠起搏器治疗30例胃动力紊乱性疾病患者(治疗组)，并与胃肠起搏空白输出机治疗组及普瑞博思治疗组对照比较。治疗前后检查胃电图，记录胃电频率、幅值，观察临床症状。结果：治疗组、空白组、普瑞博思组的临床症状总有效率分别为90．0％、46．6％、86．7％，治疗组和普瑞博思组的治疗前后症状积分比较差别有显著性(P＜0．05)；治疗组治疗后胃电图空腹、餐后平均频率较治疗前明显改善(P＜0．05)，趋向正常频率；普瑞博思组仅治疗后餐后胃电平均频率较治疗前有改善(P＜0．05)，空白组胃电频率治疗前后差异无统计学意义。结论：胃肠起博器治疗胃动力紊乱性疾病可改善临床症状及胃电生理的频率。     

新生儿胃肌电变化的研究

目的 观察新生儿胃肌电发育过程，并初步探讨其变化规律。方法 对23例健康新生儿生后1周、2周及1月进行胃肌电描记。采用皮肤表面电极，从腹壁体表用PCPOLYGRAP-HR多功能胃肠检测仪记录胃电，观察主频率(DF)、主频率不稳定系数(DFIC)、正常胃慢波百分比(PNSW)。结果 餐前、餐后正常呈随周龄增大而增加的趋势，餐后PNSW明显高于餐前。DF和DFIC各阶段无明显差异，但自身比较，餐后DF高于餐前，餐后DFIC低于餐前。结论 研究显示出新生儿胃电肌运动的发育过程。     

Volume conductor effects on the spatial resolution of magnetic fields and electric potentials from gastrointestinal electrical activity

An analysis of the relative capabilities of methods for magnetic and electric detection of gastrointestinal electrical activity is presented. The model employed is the first volume conductor model for magnetic fields from GEA to appear in the literature. A mathematical model is introduced for the electric potential and magnetic field from intestinal electrical activity in terms of the spatial filters that relate the bioelectric sources with the external magnetic fields and potentials. The forward spatial filters are low-pass functions of spatial frequency, so more superficial external fields and potentials contain less spatial information than fields and potentials near the source. Inverse spatial filters, which are reciprocals of the forward filters, are high-pass functions and must be regularised by windowing. Because of the conductivity discontinuities introduced by low-conductivity fat layers in the abdomen, the electric potentials recorded outside these layers required more regularisation than the magnetic fields, and thus, the spatial resolution of the magnetic fields from intestinal electrical activity is higher than the spatial resolution of the external potentials. In this study, two smooth muscle sources separated by 5 cm were adequately resolved magnetically, but not resolved electrically. Thus, sources are more accurately localized and imaged using magnetic measurements than using measurements of electric potential.     

不同年龄段胃肌电变化的研究

目的观察不同年龄段健康人胃肌电变化,以了解人胃肌电的发展过程。方法对23例正常足月新生儿、20例健康儿童及22例健康成人于空腹后进食标准餐,并分别于餐前、餐后记录胃电图(EGG)。观察主频率(DF)、主频率不稳定系数(DFlC)及正常胃慢波百分比(PNSW)的变化。结果各组餐前、餐后胃电参数比较：新生儿组餐前、餐后PNSW均明显低于儿童组及成人组;儿童组餐前PNSW与成人组无显著差异,但餐后明显高于成人组;3组数据显示,餐前、餐后DF均呈随年龄增加而增快的趋势,而DFlC则随年龄增加而减低。结论胃电运动随年龄的增长及食物的变化而呈现出逐渐成熟的趋势。     

肝硬化患者胃动力多因素相关性研究

目的 进一步了解肝硬化患者消化道运动功能紊乱的机理及各因素间的相互关系。 方法 对46例肝硬化患者行血浆血管活性肠肽(VIP)、胃泌素、胃动素(MTL)检测;胃电图、24 h胃内pH监测;同位素核素闪烁法检测胃排空,并与正常组对照。 结果 肝硬化组与正常组,血浆VIP分别为(14.5±4.8)pmol/L和(9.7±3.4)pmol/L,t=5.181,P<0.05;胃泌素分别为(58.6±29.8)pg/ml和(38.1±14.6)pg/ml,t=3.871,P<0.01;MTL分别为(360.0±54.2)pg/ml和(422.0±48.5)pg/ml,t=5.529,P<0.05。胃电图主频、主功率进餐前后均降低,正常慢波节律减少,胃动过缓增加。胃内2 4 h pH监测反流积分增加,胃排空延迟。多元线性回归分析,相互间有显著性相关。 结论 肝硬化患者存在食管胃运动功能紊乱,表现为胃电节律紊乱、胃排空延迟。血浆胃肠激素的异常。肝硬化患者胃内pH异常,存在胃十二指肠反流。     

Time-frequency methods for detecting spike activity of stomach

It has been hypothesised by many researchers that the spike activity signals of the stomach are responsible for triggering peristaltic contractions. Since most gastric motility disorders include an abnormality in the contraction pattern, it is very important to access this information non-invasively. The aim in this study is to use abdominal electrogastrogram (EGG) signals to detect the spike activity signals generated by the serosa of the stomach, and hence provide clinicians with a better method to monitor the motility state of the stomach. Through second and third-order spectral estimations performed on the serosal data obtained from canine experiments, it was concluded that the spike activity in serosal signals occupies a frequency range of 50-80 cycles per minute. An increase in this frequency range during strong antral contractions was observed both in the serosal and cutaneous power spectra. By using the 'continuous wavelet transform' with respect to a modified Morlet wavelet, the spike activity signals generated from the serosa of the stomach can be detected and quantified in time from the cutaneous EGG records. During phase III contraction episodes, a detection accuracy of up to 96% from the cutaneous EGG recordings was calculated based on the scored serosal spike activities simultaneously recorded.     

便携式长时间胃电记录系统的研制

体表胃电图(electrogastrogram,ECG)具有幅值小,频率低和窄带宽的特点,并且极易受到心电、呼吸以及运动等干扰.我们研究了一种基于单片机的胃电检测方法,可以有效地从体表记录到胃电信号,采用低功耗设计,可长时间进行胃电测量.将MMC卡作为胃电的存储器,通过在MMC卡上创建FAT文件系统,可使记录的胃电数据以标准文件的格式存储在MMC卡上,保证了后续的Windows环境下数据的处理.     

Physiological Response Patterns in Ulcer Patients: Phasic and Tonic Components of the Electrogastrogram

Physiological response patterns in duodenal ulcer patients, rheumatoid arthritics, and healthy subjects were investigated by recording electrogastrograms (EGGs) and several other physiological measures during presentations of mildly stressful stimuli. Ulcer patients were physiologically less reactive to the stimuli than the other groups; with the exception of increases in tonic galvanic skin potential (GSP) responses during arithmetic problems, ulcer patients were responsive only while viewing slides taken during autopsies when they evidenced increases in gastric activity and phasic GSP responses. The EGG proved to be a valuable measure for differentiating both the groups and the tasks. Both ulcer patients and healthy subjects demonstrated increases in phasic (frequency and amplitude) EGG activity during affective but not during cognitive stimuli, and ulcer patients and arthritics could be differentiated from healthy subjects on the basis of tonic (basal resting levels and displacement) EGG activity. These results were interpreted to surest the possibility that phasic and tonic components of the EGG may each be associated with different types of gastrointestinal activity.