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1.
目的:对中国药典收载的头孢噻肟钠聚合物测定条件进行改进。 方法 :采用高效液相色谱法 ,以Sephadex G- 10色谱柱 4 2 cm× 1.3cm对 6批样品进行分析 ,分别进样 5 0μl和 2 0 0μl,按外标法计算聚合物的量。结果:头孢噻肟钠在 10~ 6 0 μg/m l范围内线性关系良好 (r=0 .9995 ) ,高中低浓度的加样回收率分别为 10 0 .2 %、10 0 .4 %、99.7% ;RSD分别为 1.7%、1.5 %、1.9% (n =3)。该方法与药典方法比较 ,差异无统计学意义 (P >0 .0 5 )。 结论:本方法简便、快速、可行 ,具有实用价值 相似文献
2.
优立新与头孢噻肟随机对照治疗呼吸道和泌尿道感染40例,临床有效率各为100%和95%(P>0.05),细菌阴转率各为94,1%和100%(P>0.05)。无显著性差异。优立新共治疗30例,临床有效率和细菌阴转率分别为100%和96%。两药副反应均轻微。无因副反应而停药。在优立新治疗病例中,有2例出现皮疹。另2例为肝功能ALT和AST暂时性轻度增高。 相似文献
3.
阿奇霉素治疗细菌性感染的临床疗效 总被引:2,自引:0,他引:2
目的:评价注射用阿奇霉素治疗细菌性感染的有效性及安全性。方法:60例呼吸系统和泌尿系统细菌感染性疾病患者随机分为治疗组和对照组,每组30例,治疗组静滴阿奇霉素250 mg,qd,疗程5 d。对照组静滴头孢噻肟钠2 g,qd,疗程7d。结果:治疗组与对照组治疗细菌感染性疾病的有效率分别为90.0%与80.0%,两组比较无统计学差异(P>0.05);细菌清除率分别为89.3%与62.1%,两组比较有统计学差异(P<0.05);不良反应发生率均为6.7%。结论:注射用阿奇霉素治疗细菌性感染疗效高、安全性好。 相似文献
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Dr. F. Lauridsen M.D. K. Bjoernsen M.D. S. A. A. Damgaard Nielsen M.D. O. Hart Hansen M.D. PhD. 《Diseases of the colon and rectum》1988,31(1):25-27
In a controlled, randomized study the effect of penicillin and streptomycin on postoperative septic complications in colorectal
surgery (penicillin, 2 ml, IU, intramuscularly, three times daily for a period of six days and concomitantly streptomycin,
0.5 gm, intramuscularly, two times daily for a period of four days) was compared with the effect of cefotaxime, 2 gm, intravenously,
three times on the day of surgery. One hundred patients completed the study: 48 were treated with penicillin and streptomycin
(Group 1) and 52 with cefotaxime (Group 2). Wound infection occurred in one patient (2.1 percent) in Group 1, but not in Group
2 (0%, N.S.). Rupture of the wound occurred in one patient in each group (2.1 percentvs. 1.9 percent, N.S.). Insufficiency of the anastomosis occurred in four patients in Group 1 (8.3 percent) and in one patient
in Group 2 (1.9 percent). It is concluded that short-term prophylaxis with cefotaxime is as effective as long-term prophylaxis
with penicillin and streptomycin. 相似文献
6.
李汀 《胃肠病学和肝病学杂志》2014,(2):205-207
目的分析头孢噻肟钠联合培菲康治疗肝硬化自发性腹膜炎(spontaneous bacterial peritonitis,SBP)的临床疗效和不良反应。方法选取西安市第四医院就诊的84例肝硬化SBP患者,依据治疗方案不同分为:研究组41例,应用头孢噻肟钠联合培菲康治疗;对照组43例,仅应用头孢噻肟钠治疗。两组疗程均为14 d,比较两组患者临床疗效及不良反应的差异。结果与对照组相比,研究组的显效率、有效率及总有效率显著较高(P0.05),发热、腹痛、腹胀、腹部压痛及腹水菌群等临床表现缓解时间明显较短(P0.05),且肝功能衰竭、低血压性休克及病死率显著减少(P0.05)。结论头孢噻肟钠联合培菲康治疗肝硬化SBP疗效显著,不良反应少。 相似文献
7.
目的:探讨头孢噻肟结合中成药对婴幼儿肺炎患儿血C-反应蛋白(CRP)水平的影响。方法:对未能住院的42例婴幼儿肺炎采用头孢噻肟结合中成药治疗,并对其治疗前及治疗7d后的血CRP水平、临床症状和体征等进行评估。结果:总有效率为81.0%;血CRP水平从治疗前的(45.27±15.70)mg.L-1降至(10.38±7.26)mg.L-1,前后比较有统计学差异(P<0.01)。结论:头孢噻肟结合中成药对婴幼儿肺炎患儿的血CRP有较好的干预效果,该方法治疗婴幼儿肺炎是可取的、有效的、安全的。 相似文献
8.
The solubilization of dimyristoylphosphatidylcholine (DMPC) liposomes by the weak electrolyte drug, cefotaxime (CFX), has been studied as a function of pH, DMPC, temperature, presence of cholesterol (CHOL), and method of liposome preparation. At 7.5mMCFX the lag time for solubilization increased, the rate of solubilization decreased, and the minimum turbidity reached increased as a function of DMPC at pH 1.0 and 40C. Solubilization was most pronounced at pHs below the pKa but inhibited at least one pH unit above the pKa. The critical mole ratio of unionized CFX:DMPC, Rec, for solubilization was estimated to be 0.12. Reducing the temperature slowed the rate of solubilization as did the addition of CHOL. Encapsulation of CFX in liposomes did not significantly reduce CFX degradation, k1=0.048h-1 at 40C and a complex of DMPC and a degradation product of CFX precipitated as rectangular crystals. As a result, an increase in the turbidity of solubilized systems was observed from about 20h to 48h depending on the conditions. Liposomes in the gel state or with at least 20% CHOL did not undergo an apparent reversal of solubilization. It is concluded that the inclusion of weak electrolyte drugs existing predominantly as the unionized species in liquid crystalline state liposomes may undergo a slow solubilization process not necessarily recognized during characterization. 相似文献
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10.
Dr. G. G. Papakonstantinou J. R. Bogner F. Hofmeister R. Hehlmann 《Journal of molecular medicine (Berlin, Germany)》1993,71(2):165-167
Summary We report the successful desensitization to cefotaxime in a patient with severe lumbar osteomyelitis of unknown bacteriology and hypersentivity to the drug. Desensitization was carried out because of the unknown bacteriology, the favorable response to cefotaxime at that time, and hypersensitivity to other antibiotics. On the first day the patient received 1 mg cefotaxime intravenously. The dose was increased for 13 successive days to 4 g cefotaxime intravenously per day. No allergic reaction occurred during densitization or within 4 weeks of observation under this therapy. Patients with severe infections of unknown bacteriology might benefit from desensitization if therapy with a second-choice antibiotic is impossible.Dedicated to Prof. Dr. N. Zöllner on the occasion of his 70th birthday 相似文献