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1.
Chigozie Jesse Uneke Abel Ebeh Ezeoha Henry Uro-Chukwu Chinonyelum Thecla Ezeonu Ogbonnaya Ogbu Friday Onwe Chima Edoga 《Online Journal of Public Health Informatics》2015,7(2)
Background
In Nigeria, one of the major challenges associated with evidence-to-policy link in the control of infectious diseases of poverty (IDP), is deficient information literacy knowledge and skill among policymakers. There is need for policymakers to acquire the skill to discover relevant information, accurately evaluate retrieved information and to apply it correctly.Objectives
To use information literacy tool of International Network for Availability of Scientific Publications (INASP) to enhance policymakers'' knowledge and skill for policymaking on control of IDP in Nigeria.Methods
Modified "before and after" intervention study design was used in which outcomes were measured on target participants both before the intervention is implemented and after. This study was conducted in Ebonyi State, south-eastern Nigeria and participants were career health policy makers. A two-day health-policy information literacy training workshop was organized to enhance participants" information literacy capacity. Topics covered included: introduction to information literacy; defining information problem; searching for information online; evaluating information; science information; knowledge sharing interviews; and training skills.Results
A total of 52 policymakers attended the workshop. The pre-workshop mean rating (MNR) of knowledge and capacity for information literacy ranged from 2.15-2.97, while the post-workshop MNR ranged from 3.34-3.64 on 4-point scale. The percentage increase in MNR of knowledge and capacity at the end of the workshop ranged from 22.6%-55.3%.Conclusion
The results of this study suggest that through information literacy training workshop policy makers can acquire the knowledge and skill to identify, capture and share the right kind of information in the right contexts to influence relevant action or a policy decision. 相似文献2.
Genetic bottlenecks, perceived racism, and hypertension risk among African Americans and first-generation African immigrants 总被引:2,自引:0,他引:2
Poston WS Pavlik VN Hyman DJ Ogbonnaya K Hanis CL Haddock CK Hyder ML Foreyt JP 《Journal of human hypertension》2001,15(5):341-351
The complexity of factors influencing the development of hypertension (HTN) in African Americans has given rise to theories suggesting that genetic changes occurred due to selection pressures/genetic bottleneck effects (ie, constriction of existing genetic variability) over the course of the slave trade. Ninety-nine US-born and 86 African-born health professionals were compared in a cross-sectional survey examining genetic and psychosocial predictors of HTN. We examined the distributions of three genetic loci (G-protein, AGT-235, and ACE I/D) that have been associated with increased HTN risk. There were no significant differences between US-born African Americans and African-born immigrants in the studied genetic loci or biological variables (eg, plasma renin and angiotensin converting enzyme activity), except that the AGT-235 homozygous T genotype was somewhat more frequent among African-born participants than US-born African Americans. Only age, body mass index, and birthplace consistently demonstrated associations with HTN status. Thus, there was no evidence of a genetic bottleneck in the loci studied, ie, that US-born African Americans have different genotype distributions that increase their risk for HTN. In fact, some of the genotypic distributions evidenced lower frequencies of HTN-related alleles among US-born African Americans, providing evidence of European admixture. The consistent finding that birthplace (ie, US vs Africa) was associated with HTN, even though it was not always significant, suggests potential and unmeasured cultural, lifestyle, and environmental differences between African immigrants and US-born African Americans that are protective against HTN. 相似文献
3.
Western blot-indeterminate results in Nigerian patients HIV serodiagnosis: the clinical and public health implication 总被引:1,自引:0,他引:1
The clinical and public health implication of HIV Western blot (WB) indeterminate results is yet to be appraised in sub-Saharan Africa, including Nigeria. Using HIV Tri Line Test enzyme-linked immunosorbent assay (ELISA), 1286 patients (600 males and 686 females; age range, 5-60 years) with symptoms suggestive of HIV infection were screened. A total of 1020 (79.3%, 95% confidence interval [CI] 76.8-81.5) of the patients comprising of 514 (85.7%) males and 506 (73.8%) females were HIV seropositive and the difference was statistical significantly (chi(2) = 5.72, df = 1, p < 0.05). Western blot analysis of sera from the 1020 HIV-seropositive individuals using the BIO-RAD NEW LAV-BLOT I specifying World Health Organization (WHO) interpretive criteria, confirmed the HIV serostatus of 815 (79.9%, 95% CI, 77.4-82.4) of them with 205 (20.1%, 95% CI, 17.6-22.6) individuals having indeterminate results consisting of either; 1 env +/- gag +/- pol, gag + pol, gag only or pol only. Of these, 102 (19.8%) were males and 103 (20.4%) were females. Patients aged 11-20 years old recorded the highest percentage of indeterminate results (31.7%, 95% CI, 20.2-43.2) while those aged 21-30 years recorded the least (14.2%, 95% CI, 10.6-17.8) and the difference was statistically significant (chi(2) = 15.73, df = 5, p < 0.05). Result confirmed the limitation of Western blot assays in HIV confirmatory serodiagnosis. After obtaining HIV indeterminate Western blot result, clinicians should consider the total profile for the patient, reassess risk factors for HIV infection, perform a HIV retesting at 3-month intervals for 6 months or use an alternate HIV antibody confirmatory assay and running antibody tests for other human retroviruses. 相似文献
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Maurice M. Iwu Ogo A. Igboko Ogbonnaya K. Elekwa Michael S. Tempesta 《Phytotherapy research : PTR》1990,4(4):157-159
Kolaviron, a mixture of Garcinia biflavonoids GB-1 (II-3-I-4′-II-4″-I-5-II-5-I-7-II-7-heptahydroxy-3,8″-biflavanone), GB-2 (II-3-II-3′-I-4′-II-4″-I-5-II-5-I-7-II-7-octahydroxy-3,8″-biflavanone) and kolaflavanone (II-3-II-3′-II-4″-I-5-II-5-I-7-II-7-heptahydroxy-3,8″-biflavanone) obtained from Garcinia kola, protected rats against the toxic effects of thioacetamide in vivo. The biflavonoid mixture at a dose of 100mg/kg i.p. reduced the thiopental-induced sleep in thioacetamide-poisoned rats, both in the chronic and acute test models. The microsomal enzyme levels in the serum of rats poisoned with thioacetamide were also significantly altered by treatment with kolaviron. 相似文献
7.
Chinedum Ogbonnaya Eleazu Kate Chinedum Eleazu Mercy Amarachi Iroaganachi 《Pharmaceutical biology》2016,54(1):91-97
Context: The possibility of combining unripe plantain [Musa paradisiacae Linn (Plantaginaceae)] and cocoyam [Colocassia esculenta Linn (Araceae)] in the management of diabetes has not been investigated.Objective: The objective of this study is to evaluate the antihyperglycemic and antihyperlipidemic actions of unripe plantain and cocoyam.Materials and methods: Diabetes was induced in rats by intraperitoneal injection of streptozotocin (STZ) (65?mg/kg body weight). Twelve days after STZ induction, respective groups of diabetic rats were fed cocoyam (810?g/kg), unripe plantain (810?g/kg), and unripe plantain?+?cocoyam (405:405?g/kg) for 28?d. Body weights, feed intake, biochemical parameters, namely serum glucose, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherogenic index, coronary risk index, triacylglycerol, glycated hemoglobin (HbA1C), hepatic isocitrate dehydrogenase, malic enzyme, and glucose-6-phosphate dehydrogenase of the rats and phytochemical composition of the test and standard rat feeds were measured.Results and discussion: Cocoyam or unripe plantain alone significantly (p?<?0.05) ameliorated the body weights (18.89 and 19.95% decreases, respectively) and biochemical parameters as compared with those of STZ controls (31.21% decrease). While combination of cocoyam and unripe plantain significantly (p?<?0.05) ameliorated the biochemical parameters of the rats (except HbA1C), it did not ameliorate their body weights (28.53% decrease). The feed intake of the experimental rats did not differ from each other (p?>?0.05) at the end of experimentation and the feed samples contained considerable amounts of saponins, alkaloids, flavonoids, and tannins.Conclusion: Cocoyam or unripe plantain alone showed better antihyperglycemic and anihyperlipidemic action than their combination. 相似文献
8.
Babajide Keshinro Trevor A Crowell Rebecca G Nowak Sylvia Adebajo Sheila Peel Charlotte A Gaydos Cristina Rodriguez‐Hart Stefan D Baral Melissa J Walsh Ogbonnaya S Njoku Sunday Odeyemi Teclaire Ngo‐Ndomb William A Blattner Merlin L Robb Manhattan E Charurat Julie Ake 《Journal of the International AIDS Society》2016,19(1)
9.
We commenced autologous blood transfusion at the plastic surgery unit of the National Orthopaedic Hospital, Enugu, Nigeria in January 2001. Forty-three patients who have so far had autologous blood transfusion up to June 2004 are reviewed. Autologous blood was found to be cheaper than homologous blood with no untoward reactions. We conclude that autologous blood is safe, cheap and should be considered in elective surgical cases. 相似文献
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