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排序方式: 共有159条查询结果,搜索用时 31 毫秒
1.
Clinical Rheumatology - Nociplastic pain (NP), as a mechanistic term, denotes pain arising from altered nociception without clear evidence of tissue or somatosensory damage. Fibromyalgia (FM), a... 相似文献
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Brian E. Dixon Jamie Pina Hadi Kharrazi Fardad Gharghabi Janise Richards 《Online Journal of Public Health Informatics》2015,7(2)
Objective: To categorize and describe the public health informatics (PHI) and
global health informatics (GHI) literature between 2012 and 2014.Methods: We conducted a semi-systematic review of articles published between
January 2012 and September 2014 where information and communications
technologies (ICT) was a primary subject of the study or a main component of the
study methodology. Additional inclusion and exclusion criteria were used to
filter PHI and GHI articles from the larger biomedical informatics domain.
Articles were identified using MEDLINE as well as personal bibliographies from
members of the American Medical Informatics Association PHI and GHI working
groups.Results: A total of 85 PHI articles and 282 GHI articles were identified. While
systems in PHI continue to support surveillance activities, we identified a
shift towards support for prevention, environmental health, and public health
care services. Furthermore, articles from the U.S. reveal a shift towards PHI
applications at state and local levels. GHI articles focused on telemedicine,
mHealth and eHealth applications. The development of adequate
infrastructure to support ICT remains a challenge, although we identified a
small but growing set of articles that measure the impact of ICT on clinical
outcomes.Discussion: There is evidence of growth with respect to both implementation of
information systems within the public health enterprise as well as a widening of
scope within each informatics discipline. Yet the articles also illuminate the
need for more primary research studies on what works and what does not as both
searches yielded small numbers of primary, empirical articles.Conclusion: While the body of knowledge around PHI and GHI continues to mature,
additional studies of higher quality are needed to generate the robust evidence
base needed to support continued investment in ICT by governmental health
agencies. 相似文献
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Clinical Rheumatology - Although fibromyalgia (FM) has been traditionally defined by the extent of physical pain sites alongside other non-pain symptoms, recent evidence has highlighted the... 相似文献
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Seyed Mostafa Monzavi Aida Alirezaei Zhaleh Shariati-Sarabi Jalil Tavakol Afshari Mahmoud Mahmoudi Banafsheh Dormanesh Faezeh Jahandoost Ali Reza Khoshdel Ali Etemad Rezaie 《Inflammopharmacology》2018,26(5):1175-1182
Background
Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines in SLE patients.Methods
In this prospective cohort study, 41 newly diagnosed SLE patients receiving 400 mg HCQ per day were included. Patients requiring statins and immunosuppressive drugs except prednisolone at doses lower than 10 mg/day were excluded. Outcome measures were assessed before commencement of HCQ therapy (baseline visit) as well as in two follow-up visits (1 and 2 months after beginning the HCQ therapy). Serum samples of 41 age-matched healthy donors were used as controls.Results
Median levels of IL-1β (p?<?0.001), IL-6 (p?=?0.001), and TNF-α (p?<?0.001) were significantly higher, whereas, median CH50 level was significantly lower (p?<?0.001) in SLE patients compared with controls. Two-month treatment with HCQ resulted in significant decrease in SLEDAI-2K (p?<?0.001), anti-dsDNA (p?<?0.001), IL-1β (p?=?0.003), IL-6 (p?<?0.001) and TNF-α (p?<?0.001) and a significant increase in CH50 levels (p?=?0.012). The reductions in SLEDAI-2K and serum levels of IL-1β and TNF-α were significantly greater in the first month compared with the reductions in the second month.Conclusion
HCQ therapy is effective on clinical improvement of SLE patients through interfering with inflammatory signaling pathways, reducing anti-DNA autoantibodies and normalizing the complement activity.6.
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Zarrindast MR Ramezani-Tehrani B Ghadimi M 《Pharmacology, biochemistry, and behavior》2002,72(1-2):203-207
Straub-tail behavior was induced by subcutaneous injection of different doses (10-60 mg/kg) of morphine to mice. The maximum response was obtained with 20-40 mg/kg of the drug. The response induced by morphine (40 mg/kg) was decreased by intraperitoneal administration of different doses of clonidine (0.05-0.1 mg/kg). Pretreatment of animals with yohimbine (1-4 mg/kg i.p.) reversed the inhibitory action of clonidine. Yohimbine did not elicit any response by itself. Administration of prazosin (0.25, 0.5, and 1 mg/kg) reduced the morphine response. The combination of prazosin with yohimbine (1 mg/kg), but not with clonidine (0.05 mg/kg), caused a potentiated inhibition of the morphine effect. Phenylephrine (2-6 mg/kg i.p.) did not elicit any effect by itself and also did not alter the response induced by morphine or morphine plus clonidine. Dobutamine (2.5-10 mg/kg i.p.), atenolol (2.5-10 mg/kg i.p.), salbutamol (2.5-10 mg/kg i.p.), and propranolol (2.5-10 mg/kg i.p.) did not alter morphine-induced Straub-tail behavior in mice. In conclusion, activation of alpha2-adrenergic pathways contributes to morphine-induced Straub tail, while alpha1- and beta2-adrenergic may not be involved in this phenomenon. 相似文献
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Rajavi Z Ghadim HM Nikkhoo M Dehsarvi B 《Journal of pediatric ophthalmology and strabismus》2001,38(5):273-277
PURPOSE: To compare the results of hang-back and conventional recession surgery. METHODS: This randomized, double-blind, matched clinical trial comprised 30 patients with esotropia and 24 with exotropia. All ocular examinations before and at least 1.5 months after surgery were performed by an orthoptist who was unaware of the method of recession. All surgeries were performed by the same surgeon. RESULTS: In patients with esotropia, deviation improved from 31+/-9 prism diopters (delta) preoperatively to 7+/-6 delta postoperatively for hang-back recession (n=15) and from 41+/-14 delta to 6+/-6 delta for conventional recession (n=15). Postoperative horizontal deviation was >10 delta in 40% of patients who underwent hang-back recession and 20% of patients who underwent conventional recession (P<.8). In patients with exotropia, deviation improved from 28.9+/-9 delta preoperatively to 0.5+/-11 delta postoperatively for hang-back recession (n=12) and from 29+/-8 delta to 6+/-6 delta for conventional recession (n=12). Postoperative horizontal deviation was >10 delta in 24% of patients who underwent hang-back recession and 17% of patients who underwent conventional recession (P<.2). Mean follow-up was 7 months. CONCLUSION: Hang-back recession is an alternative to conventional rectus muscle recession, especially in children who have smaller globes and patients with myopia or collagen vascular diseases. 相似文献
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